NORTHFIELD LABORATORIES INC.

                               POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS, that the undersigned director and/or executive
officer (the "Reporting Person") of Northfield Laboratories Inc., a Delaware
corporation (the "Company"), hereby constitutes and appoints Jack J. Kogut (the
"Attorney-in-Fact") as the Reporting Person's true and lawful agent and
attorney-in-fact to:

    o   execute for and on behalf of the Reporting Person, in the Reporting
        Person's capacity as a director and/or executive officer of the Company,
        Forms 3, 4 and 5 in accordance with requirements of Section 16(a) of the
        Securities Exchange Act of 1934, as amended (the "Securities Exchange
        Act") and the rules promulgated by the Securities and Exchange
        Commission (the "SEC") thereunder;

    o   do and perform any and all acts for and on behalf of the Reporting
        Person which may be necessary or desirable to complete and execute any
        such Form 3, 4 or 5, complete and execute any amendment or amendments
        thereto, and timely file such form with the SEC and any stock exchange
        or similar authority; and

    o   take any other action of any type whatsoever in connection with the
        foregoing which, in the opinion of the Attorney-in-Fact, may be of
        benefit, to, in the best interest of or legally required by the
        Reporting Person.

    The Reporting Person hereby grants to the Attorney-in-Fact full power and
    authority to do and perform any and every act and thing whatsoever
    requisite, necessary or proper to be done in the exercise of any of the
    rights and powers herein granted, as fully to all intents and purposes as
    the Reporting Person might or could do if personally present, with full
    power of substitution or revocation, hereby ratifying and confirming all
    that the Attorney-in-Fact, or the Attorney-in-Fact's substitute or
    substitutes, may lawfully do or cause to be done by virtue of this Power of
    Attorney and the rights and powers herein granted.

         The Reporting Person understands that compliance with the requirements
    of Section 16 of the Securities Exchange Act and the rules promulgated by
    the SEC thereunder is the responsibility of the Reporting Person as director
    and/or executive officer of the Company and that the Company and the
    Attorney-in-Fact have agreed to assist the Reporting Person with filing the
    reports the Reporting Person is required to submit under Section 16 solely
    as an accommodation to assist the Reporting Person in complying with this
    responsibility. The Reporting Person further acknowledges that the Reporting
    Person is not relying upon the Company or any of its employees or agents,
    including the Attorney-in-Fact and legal counsel for the Company, for legal
    advice in connection with the Reporting Person's compliance with the
    requirements of Section 16 and that the Reporting Person has consulted his
    or her personal legal



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    counsel with respect to any questions the Reporting Person may have
    regarding these requirements. The Reporting Person acknowledges that the
    Attorney-in-Fact, in serving in such capacity at the request of the
    Reporting Person, is not assuming, nor is the Company assuming, any of the
    Reporting Person's responsibilities to comply with Section 16 of the
    Securities Exchange Act.

         In consideration of the Attorney-in-Fact acting on the Reporting
    Person's behalf pursuant to this Power of Attorney, the Reporting Person
    hereby agrees to indemnify and hold the Attorney-in-Fact, each substitute
    attorney-in-fact, and each of their respective heirs, executors, legal
    representatives, successors, and assigns harmless from and against the
    entirety of any and all losses, claims, causes of action, damages, fines,
    defense costs, amounts paid in settlement, liabilities and expenses,
    including reasonable attorneys' fees and expenses (collectively, "Losses"),
    relating to or arising out of the exercise of this Power of Attorney by the
    Attorney-in-Fact or any substitute Attorney-in-Fact, and will reimburse each
    such indemnified person for all Losses as they are incurred by such
    indemnified person in connection with any pending or threatened claim,
    action, suit proceedings or investigation with which such indemnified person
    is or is threatened to be made a party. The Reporting Person will not,
    however, be responsible for any Losses that are finally determined by a
    court of competent jurisdiction to have resulted solely from the
    Attorney-in-Fact's bad faith or knowing and willful misconduct.

         This Power of Attorney will remain in full force and effect until the
    Reporting Person is no longer to file Forms 3, 4 and 5 with respect to the
    Reporting Person's holdings of and transactions in securities issued by the
    Company, unless earlier revoked by the Reporting Person in a signed writing
    delivered to the Attorney-in-Fact.

         IN WITNESS WHEREOF, the Reporting Person has caused this Power of
    Attorney to be executed as of this 21st day of January, 2004.


                                              /s/ Sophia Twaddell
                                              ------------------------
                                              Sophia Twaddell