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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 BH3PwkcvgGn6DbLb4JMW4Q/iqZnsIqHGi8UvK3nU6SxgT+EPrQ434L0/2BYmkKIU
 K1b5ivJNcIinzZI76VG6Xw==

<SEC-DOCUMENT>0001209191-03-028419.txt : 20031104
<SEC-HEADER>0001209191-03-028419.hdr.sgml : 20031104
<ACCEPTANCE-DATETIME>20031104151836
ACCESSION NUMBER:		0001209191-03-028419
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031103
FILED AS OF DATE:		20031104

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NORTHFIELD LABORATORIES INC /DE/
		CENTRAL INDEX KEY:			0000920947
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				363378733
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0531

	BUSINESS ADDRESS:	
		STREET 1:		1560 SHERMAN AVE
		STREET 2:		SUITE 1000
		CITY:			EVANSTON
		STATE:			IL
		ZIP:			60201-4800
		BUSINESS PHONE:		8478643500

	MAIL ADDRESS:	
		STREET 1:		1560 SHERMAN AVE STE 1000
		STREET 2:		37TH FLOOR
		CITY:			EVANSTON
		STATE:			IL
		ZIP:			60201-4800

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DOUBLEDAY MARC
		CENTRAL INDEX KEY:			0001200265

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-24050
		FILM NUMBER:		03976094

	BUSINESS ADDRESS:	
		STREET 1:		1560 SHERMAN AVENUE
		STREET 2:		SUITE 1000
		CITY:			EVANSTON
		STATE:			IL
		ZIP:			60201
		BUSINESS PHONE:		8478643500

	MAIL ADDRESS:	
		STREET 1:		1560 SHERMAN AVENUE
		STREET 2:		SUITE 1000
		CITY:			EVANSTON
		STATE:			IL
		ZIP:			60201
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c80640-01md.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?><ownershipDocument><schemaVersion>X0201</schemaVersion>    <documentType>4</documentType><periodOfReport>2003-11-03</periodOfReport><notSubjectToSection16>0</notSubjectToSection16><issuer><issuerCik>0000920947</issuerCik><issuerName>NORTHFIELD LABORATORIES INC /DE/</issuerName>        <issuerTradingSymbol>NFLD</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001200265</rptOwnerCik><rptOwnerName>DOUBLEDAY MARC</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1></rptOwnerStreet1><rptOwnerStreet2>SUITE 1000</rptOwnerStreet2><rptOwnerCity>EVANSTON</rptOwnerCity><rptOwnerState>IL</rptOwnerState><rptOwnerZipCode>60201</rptOwnerZipCode><rptOwnerStateDescription></rptOwnerStateDescription></reportingOwnerAddress><reportingOwnerRelationship><isDirector>0</isDirector><isOfficer>1</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther><officerTitle>Vice President</officerTitle></reportingOwnerRelationship></reportingOwner><derivativ
eTable><derivativeTransaction><securityTitle><value>Option, Right-to-buy</value><footnoteId id="F1" /></securityTitle><conversionOrExercisePrice><value>5.94</value></conversionOrExercisePrice><transactionDate><value>2003-11-03</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>25000</value></transactionShares><transactionPricePerShare><value>5.94</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><value>2007-11-03</value><footnoteId id="F2" /></exerciseDate><expirationDate><value>2013-11-03</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>25000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><shar
esOwnedFollowingTransaction><value>108000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></derivativeTransaction></derivativeTable><footnotes><footnote id="F1">The stock option was granted on November 3, 2003</footnote><footnote id="F2">The stock option becomes fully vested and exercisable on November 3, 2007.</footnote></footnotes><ownerSignature><signatureName>/s/ Marc Doubleday</signatureName><signatureDate>2003-11-03</signatureDate></ownerSignature></ownershipDocument>

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</SEC-DOCUMENT>
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