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Deferred Royalty Obligation - Additional Information (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Aug. 05, 2022
May 10, 2018
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Dec. 31, 2021
Debt Instrument [Line Items]              
Deferred royalty obligation, net     $ 124,536   $ 124,536   $ 124,503
Interest expense     2,400 $ 2,700 4,800 $ 5,300  
Royalty obligation payable     1,000   1,000   900
HealthCare Royalty Partners              
Debt Instrument [Line Items]              
Proceeds from royalty agreement   $ 125,000          
Required payment for breach of agreement, payment two   225,000          
Required payment for breach of agreement, payment one   125,000          
Payment for royalty agreement   10,600          
HealthCare Royalty Partners | Subsequent Event [Member]              
Debt Instrument [Line Items]              
Required payment for breach of agreement, payment two $ 225,000            
Required payment for breach of agreement, payment one $ 125,000            
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable              
Debt Instrument [Line Items]              
Deferred royalty obligation, net   125,000 124,500   124,500   124,500
Debt issuance costs   $ 700          
Unamortized debt discount     500   500   500
Accrued interest expense     32,500   32,500   29,800
Royalty payments     1,100 $ 700 2,000 $ 1,600  
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable | Other Noncurrent Liabilities              
Debt Instrument [Line Items]              
Accrued interest expense     $ 26,800   $ 26,800   $ 24,600
HealthCare Royalty Partners | Period One              
Debt Instrument [Line Items]              
Maximum potential royalty payout   10.00%          
HealthCare Royalty Partners | Period Two              
Debt Instrument [Line Items]              
Increase in maximum potential payout percent   4.00%          
HealthCare Royalty Partners | Period Three              
Debt Instrument [Line Items]              
Increase in maximum potential payout percent   4.00%