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Deferred Royalty Obligation - Additional Information (Details) - USD ($)
$ in Thousands
3 Months Ended
May 10, 2018
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
Debt Instrument [Line Items]        
Deferred royalty obligation, net   $ 124,519   $ 124,503
Interest expense   2,400 $ 2,600  
Royalty obligation payable   1,100   900
HealthCare Royalty Partners        
Debt Instrument [Line Items]        
Proceeds from royalty agreement $ 125,000      
Required payment for breach of agreement, payment two 225,000      
Required payment for breach of agreement, payment one 125,000      
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable        
Debt Instrument [Line Items]        
Deferred royalty obligation, net 125,000 124,500   124,500
Debt issuance costs $ 700      
Unamortized debt discount   500   500
Accrued interest expense   31,200   29,800
Royalty payments   900 $ 900  
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable | Other Noncurrent Liabilities        
Debt Instrument [Line Items]        
Accrued interest expense   $ 25,300   $ 24,600
HealthCare Royalty Partners | Period One        
Debt Instrument [Line Items]        
Maximum potential royalty payout 10.00%      
HealthCare Royalty Partners | Period Two        
Debt Instrument [Line Items]        
Increase in maximum potential payout percent 4.00%      
HealthCare Royalty Partners | Payout Period        
Debt Instrument [Line Items]        
Increase in maximum potential payout percent 4.00%