Consolidated Statements of Cash Flows $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Operating activities
Net income (loss)	$ 19,660	$ (39,421)
Adjustments to reconcile net income (loss) to net cash provided by (used for) operating activities:
Non-cash interest expense	7,141	6,379
Share-based compensation expense	4,477	6,207
Amortization of intangible assets	1,552	647
Amortization of right-of-use lease assets	218	1,249
Depreciation expense	111	2,188
Inventory fair value step-up adjustment included in cost of product sales	850	2,458
Gain on change in fair value of contingent value rights	(734)	(800)
Loss on short-term investments		502
Loss on disposal of property and equipment, net of gain on lease termination		10
Changes in operating assets and liabilities:
Accounts receivable, net	(2,776)	(1,687)
Inventory, net	(1,118)	(1,493)
Prepaid expenses and other current assets	(2,368)	2,297
Accounts payable	(484)	(2,815)
Accrued expenses	(728)	(11,423)
Deferred revenue	2,661	188
Lease liabilities	(218)	(2,126)
Net cash provided by (used for) operating activities	28,244	(37,640)
Investing activities
Acquisition of Tetraphase, net of cash, cash equivalents and restricted cash acquired		(33,513)
Proceeds from the sale of property and equipment		3,070
Purchases of property and equipment	(9)
Proceeds from the sale of short-term investments		2,497
Purchases of short-term investments		(2,999)
Net cash used for investing activities	(9)	(30,945)
Financing activities
Purchases of common stock under Stock Repurchase Plan	(3,380)
Net proceeds from issuance of common stock under ESPP	436	512
Net proceeds from issuance of common stock under 2013 Equity Plan	156	605
Net cash (used for) provided by financing activities	(2,788)	1,117
Net increase (decrease) in cash, cash equivalents and restricted cash	25,447	(67,468)
Cash, cash equivalents and restricted cash, beginning of period	21,261	88,729
Cash, cash equivalents and restricted cash, end of period	46,708	21,261
Supplemental disclosure of non-cash investing and financing activities
Initial recognition of right-of-use lease asset		536
Reconciliation of cash, cash equivalents and restricted cash to the consolidated balance sheets
Cash and cash equivalents	46,668	21,221
Restricted cash	40	40
Cash, cash equivalents and restricted cash, end of period	$ 46,708	$ 21,261