Defined Contribution Plan - Additional Information (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Defined Contribution Plan Disclosure [Line Items]
Matching contributions made	$ 0.4	$ 0.5
La Jolla Plan
Defined Contribution Plan Disclosure [Line Items]
Employer 401(k) matching contribution to employee percentage	3.50%
Tetraphase Plan
Defined Contribution Plan Disclosure [Line Items]
Employer 401(k) matching contribution to employee percentage	3.50%