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Deferred Royalty Obligation - Additional Information (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
May 10, 2018
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Debt Instrument [Line Items]            
Deferred royalty obligation, net   $ 124,470   $ 124,470   $ 124,437
Interest expense   2,700 $ 2,500 5,300 $ 4,900  
Royalty obligation payable   900   900   900
HealthCare Royalty Partners            
Debt Instrument [Line Items]            
Proceeds from royalty agreement $ 125,000          
Required payment for breach of agreement, payment two 225,000          
Required payment for breach of agreement, payment one 125,000          
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable            
Debt Instrument [Line Items]            
Deferred royalty obligation, net 125,000 124,500   124,500   124,400
Debt issuance costs $ 700          
Unamortized debt discount   500   500   600
Accrued interest expense   26,400   26,400   22,700
Royalty payments   700   1,600    
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable | Other Noncurrent Liabilities            
Debt Instrument [Line Items]            
Accrued interest expense   $ 22,100   $ 22,100   $ 19,100
HealthCare Royalty Partners | Period One            
Debt Instrument [Line Items]            
Maximum potential royalty payout 10.00%          
HealthCare Royalty Partners | Period Two            
Debt Instrument [Line Items]            
Increase in maximum potential payout percent 4.00%          
HealthCare Royalty Partners | Payout Period            
Debt Instrument [Line Items]            
Increase in maximum potential payout percent 4.00%