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Deferred Royalty Obligation - Additional Information (Details) - USD ($)
$ in Thousands
3 Months Ended
May 10, 2018
Mar. 31, 2021
Mar. 31, 2020
Dec. 31, 2020
Debt Instrument [Line Items]        
Deferred royalty obligation, net   $ 124,453   $ 124,437
Interest expense   2,600 $ 2,400  
Royalty obligation payable   700    
HealthCare Royalty Partners        
Debt Instrument [Line Items]        
Proceeds from royalty agreement $ 125,000      
Required payment for breach of agreement, payment two 225,000      
Required payment for breach of agreement, payment one 125,000      
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable        
Debt Instrument [Line Items]        
Deferred royalty obligation, net 125,000 124,500    
Debt issuance costs $ 700      
Unamortized debt discount   500    
Accrued interest expense   24,400   22,700
Royalty payments   900 $ 700  
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable | Other Noncurrent Liabilities        
Debt Instrument [Line Items]        
Accrued interest expense   $ 20,900   $ 19,100
HealthCare Royalty Partners | Period One        
Debt Instrument [Line Items]        
Maximum potential royalty payout 10.00%      
HealthCare Royalty Partners | Period Two        
Debt Instrument [Line Items]        
Increase in maximum potential payout percent 4.00%      
HealthCare Royalty Partners | Payout Period        
Debt Instrument [Line Items]        
Increase in maximum potential payout percent 4.00%