Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Operating activities
Net loss	$ (29,174)	$ (35,943)	$ (91,275)
Adjustments to reconcile net loss to net cash used for operating activities:
Share-based compensation expense		5,385	19,522
Depreciation expense		2,155	3,408
Inventory fair value step-up adjustment included in cost of product sales		1,186
Amortization of intangible assets		259
Amortization of right-of-use lease assets		1,091	969
Non-cash interest expense		5,339	6,971
Loss on short-term investments		502
Loss on disposal of property and equipment, net of gain on lease termination		59	15
Changes in operating assets and liabilities:
Accounts receivable, net		218	(36)
Inventory, net		(1,482)	110
Prepaid expenses and other current assets		2,445	328
Accounts payable		(1,649)	(3,234)
Accrued expenses		(5,786)	(332)
Accrued payroll and related expenses		(2,168)	(2,391)
Lease liabilities		(1,969)	(1,873)
Net cash used for operating activities		(30,358)	(67,818)
Investing activities
Acquisition of Tetraphase, net of cash, cash equivalents and restricted cash acquired		(33,513)
Proceeds from the sale of property and equipment		3,070
Purchases of property and equipment			(679)
Proceeds from the sale of short-term investments		2,497
Purchases of short-term investments		(2,999)
Net cash used for investing activities		(30,945)	(679)
Financing activities
Net proceeds from issuance of common stock under 2013 Equity Plan		605
Net proceeds from issuance of common stock under ESPP		428	661
Net cash provided by financing activities		1,033	661
Net decrease in cash, cash equivalents and restricted cash		(60,270)	(67,836)
Cash, cash equivalents and restricted cash, beginning of period		88,729	173,513
Cash, cash equivalents and restricted cash, end of period	105,677	28,459	105,677
Supplemental disclosure of non-cash investing and financing activities
Conversion of Series F Convertible Preferred Stock into common stock			2,737
Cumulative-effect adjustment from adoption of ASU 2018-07	(160)		(160)
Initial recognition of right-of-use lease asset			16,798
Reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets
Cash and cash equivalents	104,768	27,760	104,768
Restricted cash	909	699	909
Cash, cash equivalents and restricted cash, end of period	$ 105,677	$ 28,459	$ 105,677