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Deferred Royalty Obligation - Additional Information (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
May 10, 2018
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Dec. 31, 2019
Debt Instrument [Line Items]            
Deferred royalty obligation, net   $ 124,421   $ 124,421   $ 124,379
Interest expense   2,500 $ 2,800 7,400 $ 8,400  
Royalty Obligation Payable   700   700    
HealthCare Royalty Partners            
Debt Instrument [Line Items]            
Proceeds from royalty agreement $ 125,000          
Required payment for breach of agreement, payment two 225,000          
Required payment for breach of agreement, payment one 125,000          
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable            
Debt Instrument [Line Items]            
Deferred royalty obligation, net 125,000 124,400   124,400    
Debt issuance costs $ 700          
Unamortized debt discount   600   600    
Accrued interest expense   20,800   20,800   15,500
Royalty payments   600   2,100    
HealthCare Royalty Partners | Royalty Financing Agreement | Loans Payable | Other Noncurrent Liabilities            
Debt Instrument [Line Items]            
Accrued interest expense   $ 16,900   $ 16,900   $ 12,800
HealthCare Royalty Partners | Period One            
Debt Instrument [Line Items]            
Maximum potential royalty payout 10.00%          
HealthCare Royalty Partners | Period Two            
Debt Instrument [Line Items]            
Increase in maximum potential payout percent 4.00%          
HealthCare Royalty Partners | Payout Period            
Debt Instrument [Line Items]            
Increase in maximum potential payout percent 4.00%