Equity Incentive Plans (Tables)

9 Months Ended

Sep. 30, 2020

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

The activity related to equity awards, which are comprised of stock options and inducement grants, during the nine months ended September 30, 2020 is summarized as follows:

	Equity Awards			Weighted-average Exercise Price per Share		Weighted-average Remaining Contractual Term (years)		Aggregate Intrinsic Value
Outstanding at December 31, 2019		5,616,840		$	19.50
Granted		1,802,860		$	4.70
Exercised		(94,219	)	$	6.42
Cancelled/forfeited		(4,000,059	)	$	18.74
Outstanding at September 30, 2020		3,325,422		$	12.77		7.43	$	-
Exercisable at September 30, 2020		1,466,036		$	20.53		5.52	$	-

Share-based Compensation Expense

The classification of share-based compensation expense is summarized as follows (in thousands):

	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2020		2019		2020		2019
Research and development	$	691	$	4,169	$	3,218	$	12,062
Selling, general and administrative		697		2,250		2,167		7,460
Total share-based compensation expense	$	1,388	$	6,419	$	5,385	$	19,522