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Stockholders' Equity (Details) (USD $)	3 Months Ended		6 Months Ended
Stockholders' Equity (Details) (USD $)	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category
Share-based compensation expense	$ 2,143,000	$ 2,710,000	$ 5,609,000	$ 2,710,000
Research and development
Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category
Share-based compensation expense	251,000	248,000	647,000	248,000
General and administrative
Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category
Share-based compensation expense	$ 1,892,000	$ 2,462,000	$ 4,962,000	$ 2,462,000

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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