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Stockholders' Equity (Details) (USD $)	3 Months Ended
Stockholders' Equity (Details) (USD $)	Mar. 31, 2013	Mar. 31, 2012
Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category
Share-based compensation expense	$ 3,466,000
Research and development
Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category
Share-based compensation expense	396,000
General and administrative
Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category
Share-based compensation expense	$ 3,070,000

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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