POWER OF ATTORNEY
Know all by these presents, that the undersigned
hereby
constitutes and appoints each of Steven B. Engle and Gail A. Sloan
signing
singly, the undersigned's true and lawful attorney-in-fact to:

(1)
execute for and on behalf of the undersigned, in the undersigned's
capacity
as an officer, director or ten percent stockholder of La Jolla

Pharmaceutical Company (the "Company"), Forms 3, 4, and 5 in accordance

with Section 16(a) of the Securities Exchange Act of 1934, as amended,
and
the rules thereunder;
(2)  do and perform any and all acts for and
on
behalf of the undersigned which may be necessary or desirable to
complete
and execute any such Form 3, 4, or 5 and timely file such form
with the
United States Securities and Exchange Commission and any stock
exchange or
similar authority; and
(3)  take any other action of any
type whatsoever
in connection with the foregoing which, in the opinion of
such
attorney-in-fact, may be of benefit to, in the best interest of, or
legally
required by, the undersigned, it being understood that the
documents
executed by such attorney-in-fact on behalf of the undersigned
pursuant to
this Power of Attorney shall be in such form and shall
contain such terms
and conditions as such attorney-in-fact may approve in
such
attorney-in-fact's discretion.
The undersigned hereby grants to
each such
attorney-in-fact full power and authority to do and perform any
and every
act and thing whatsoever requisite, necessary, or proper to be
done in the
exercise of any of the rights and powers herein granted, as
fully to all
intents and purposes as the undersigned might or could do if
personally
present, with full power of substitution or revocation, hereby
ratifying
and confirming all that such attorney-in-fact, or such
attorney-in-fact's
substitute or substitutes, shall lawfully do or cause
to be done by virtue
of this Power of Attorney and the rights and powers
herein granted.  The
undersigned acknowledges that the foregoing
attorneys-in-fact, in serving
in such capacity at the request of the
undersigned, are not assuming, nor
is the Company assuming, any of the
undersigned's responsibilities to
comply with Section 16 of the
Securities Act of 1934, as amended.
This
Power of Attorney shall
remain in full force and effect until the
undersigned is no longer
required to file Forms 3, 4, and 5 with respect to
the undersigned's
holdings of and transactions in securities issued by the
Company, unless
earlier revoked by the undersigned in a signed writing
delivered to the
foregoing attorneys-in-fact.
IN WITNESS WHEREOF, the
undersigned has
caused this Power of Attorney to be executed as of November
29, 2005.




Signature:	/s/ Nader Naini

Print Name:	Nader
Naini