-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Gdh4MuCtD79dTIXartzuzPV556STKQ/i5Jat/YhjvsXD3o4SR++4HI4+Hp+bJdoG
 Hhiltuf5RjrZD/R4I9jjVA==

<SEC-DOCUMENT>0001209191-03-030002.txt : 20031112
<SEC-HEADER>0001209191-03-030002.hdr.sgml : 20031112
<ACCEPTANCE-DATETIME>20031112180716
ACCESSION NUMBER:		0001209191-03-030002
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031110
FILED AS OF DATE:		20031112

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ENGLE STEVEN B
		CENTRAL INDEX KEY:			0001234368

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-24274
		FILM NUMBER:		03995248

	BUSINESS ADDRESS:	
		STREET 1:		C/O LA JOLLA PHARMACEUTICAL CO
		STREET 2:		6455 NANCY RIDGE DRIVE
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		8586466649

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LA JOLLA PHARMACEUTICAL CO
		CENTRAL INDEX KEY:			0000920465
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				330361285
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		6455 NANCY RIDGE DR
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		8584526600

	MAIL ADDRESS:	
		STREET 1:		6455 NANCY RIDGE DR
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?><ownershipDocument><schemaVersion>X0201</schemaVersion>    <documentType>4</documentType><periodOfReport>2003-11-10</periodOfReport><notSubjectToSection16>0</notSubjectToSection16><issuer><issuerCik>0000920465</issuerCik><issuerName>LA JOLLA PHARMACEUTICAL CO</issuerName>        <issuerTradingSymbol>LJPC</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001234368</rptOwnerCik><rptOwnerName>ENGLE STEVEN B</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>6455 NANCY RIDGE DRIVE</rptOwnerStreet1><rptOwnerStreet2></rptOwnerStreet2><rptOwnerCity>SAN DIEGO</rptOwnerCity><rptOwnerState>CA</rptOwnerState><rptOwnerZipCode>92121</rptOwnerZipCode><rptOwnerStateDescription></rptOwnerStateDescription></reportingOwnerAddress><reportingOwnerRelationship><isDirector>1</isDirector><isOfficer>1</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther><officerTitle>CEO &amp; Chairman</officerTitle></reportingOwnerRelationship></reportingOwner
><nonDerivativeTable><nonDerivativeTransaction><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-11-10</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>M</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>100000.0000</value></transactionShares><transactionPricePerShare><value>1.0000</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>101484.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeTransaction><securityTitle><value>Common
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ansactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved><footnoteId id="F1" /></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>110000.0000</value></transactionShares><transactionPricePerShare><value>3.0200</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>1484.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeTransaction><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-11-11</value></transactionDate><deemedExecutionDate></deemedExecutionDat
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nsactionCoding><transactionFormType>4</transactionFormType><transactionCode>M</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>100000.0000</value></transactionShares><transactionPricePerShare><value>1.0000</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><footnoteId id="F2" /></exerciseDate><expirationDate><value>2004-01-04</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>100000.0000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>2490000.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></o
wnershipNature></derivativeTransaction><derivativeTransaction><securityTitle><value>Stock Options (right to buy)</value></securityTitle><conversionOrExercisePrice><value>1.0000</value></conversionOrExercisePrice><transactionDate><value>2003-11-10</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>M</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>10000.0000</value></transactionShares><transactionPricePerShare><value>1.0000</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><footnoteId id="F3" /></exerciseDate><expirationDate><value>2004-02-02</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecur
ityShares><value>10000.0000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>2480000.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></derivativeTransaction><derivativeTransaction><securityTitle><value>Stock Options (right to buy)</value></securityTitle><conversionOrExercisePrice><value>1.0000</value></conversionOrExercisePrice><transactionDate><value>2003-11-11</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>M</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>31000.0000</value></transactionShares><transactionPricePerShare><value>1.0000</value></transactionPricePerShare><transacti
onAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><footnoteId id="F3" /></exerciseDate><expirationDate><value>2004-02-02</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>31000.0000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>2449000.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></derivativeTransaction></derivativeTable><footnotes><footnote id="F1">The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 30, 2002, and amended on October 1, 2003.</footnote><footnote id="F2">Stock options became fully vested and exercisable on 01/04/1998.</footnote><footnote id="F3">Stock op
tions became fully vested and exercisable on 02/02/1997.</footnote></footnotes><remarks></remarks><ownerSignature><signatureName>/s/ Steven B. Engle</signatureName><signatureDate>2003-11-12</signatureDate></ownerSignature></ownershipDocument>

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</DOCUMENT>
</SEC-DOCUMENT>
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