Stockholders' Equity (Details Textual) (USD $)	1 Months Ended		12 Months Ended																12 Months Ended			1 Months Ended		12 Months Ended									12 Months Ended			12 Months Ended								12 Months Ended
	Apr. 30, 2012	Feb. 29, 2012	Dec. 31, 2012	Dec. 31, 2011	May 31, 2012	Apr. 10, 2012	Feb. 17, 2012	Jan. 19, 2012	Sep. 30, 2011	Apr. 14, 2011	Dec. 31, 2010	May 31, 2010	Dec. 31, 2012 Series C-1 Preferred [Member]	Dec. 31, 2011 Series C-1 Preferred [Member]	May 26, 2010 Series C-1 Preferred [Member]	Dec. 31, 2012 Series C-2 Preferred [Member]	Dec. 31, 2012 Series D-1 preferred	Dec. 31, 2012 Series D-2 Preferred [Member]	Dec. 31, 2012 Research and development [Member]	Dec. 31, 2012 General and administrative [Member]	Dec. 31, 2011 General and administrative [Member]	Aug. 31, 2012 Restricted Stock Units [Member]	Apr. 30, 2012 Restricted Stock Units [Member]	Dec. 31, 2012 Restricted Stock Units [Member]	Aug. 20, 2012 Restricted Stock Units [Member]	Apr. 10, 2012 Restricted Stock Units [Member]	Dec. 31, 2012 Restricted Stock Units [Member] Employee [Member]	Apr. 10, 2012 Restricted Stock Units [Member] Employee [Member]	Dec. 31, 2012 Restricted Stock Units [Member] Director [Member]	Apr. 10, 2012 Restricted Stock Units [Member] Director [Member]	Dec. 31, 2012 Restricted Stock Units [Member] Consultant [Member]	Aug. 17, 2012 Restricted Stock Units [Member] Consultant [Member]	Dec. 31, 2012 Restricted Stock Units [Member] Research and development [Member]	Dec. 31, 2012 Restricted Stock Units [Member] General and administrative [Member]	Jan. 19, 2013 Restricted Stock [Member]	Dec. 31, 2012 Restricted Stock [Member] Research and development [Member]	Dec. 31, 2012 Restricted Stock [Member] General and administrative [Member]	Dec. 31, 2012 Maximum [Member]	Dec. 31, 2012 Minimum [Member]	Dec. 31, 2012 ESPP [Member]	Dec. 31, 2012 ESPP [Member] Maximum [Member]	Dec. 31, 2012 ESPP [Member] Minimum [Member]	Dec. 31, 2012 1994 Plan [Member]	Dec. 31, 2012 2004 Plan [Member]	Jan. 01, 2013 2010 Plan [Member]	Dec. 31, 2012 2010 Plan [Member]	Oct. 31, 2012 2010 Plan [Member]	Jul. 31, 2012 2010 Plan [Member]	May 31, 2012 2010 Plan [Member]	Sep. 30, 2011 2010 Plan [Member]	May 31, 2011 2010 Plan [Member]
Stockholders' Equity (Textual) [Abstract]
Preferred stock, shares authorized			8,000,000										11,000			22,000	5,134	10,868
Preferred stock, par value			$ 0.0001												$ 0.0001
Preferred stock, shares issued													5,792	5,043	5,134	500	4,615
Preferred stock, shares outstanding													5,792	5,043		500	4,615																						1,000
Issued warrants to purchase shares			390
Exercise price of Warrants granted			21,500
Term of common stock warrants			5 years
Common Stock authorized for issuance			12,000,000,000	12,000,000,000																																							164	640		960			1,188,414
Options outstanding			592,230,567	894							980																																5	75		16
Shares remaining available for grants			1,356,722																																									537		0
Maximum percentage of the base salary of which an employee can purchase common stock																																								10.00%
Common stock are reserved for issuance upon exercise of the warrants			390																																								607,318,125	607,318,125		607,318,125
Increase in the shares of common stock authorized for issuance under the Employee Stock Purchase Plan																																									4,850,000	850,000								16,007	33
Additional common shares authorized																																													70,000	676,640,705	120,520	47,804
Share-based compensation expense			$ 8,604,000	$ 254,000															$ 805,000	$ 7,799,000	$ 254,000												$ 205	$ 755,000		$ 35,000	$ 132,000
Unamortized share-based compensation expense																											648		24,000		18,000				12,000
Restricted stock units granted																												14,219		10,360,892		270,000
Percentage of RSUs for employee vest																									45.50%	25.00%
Period of share-based payment awards			36 months																																									10 years
Service period of share compensation			1 year 2 months 12 days																					3 years
Extension term period of employee stock purchase plan																																						2025	2015
Restricted stock units weighted average grant date value	$ 0.06																					$ 0.069	$ 0.06
Stockholders' Equity (Additional Textual) [Abstract]
Reverse stock split ratio		0.0001	100				0.0001	100		0.0001
Number of shares issued for stock split		100
Outstanding warrants			390
Common stock offered for purchase to employee						592,230,471						580
Shares of common stock issued and outstanding					10.00%
Options granted at exercise price						$ 0.06
Percentage of options granted at exercise price			100.00%
Percentage of grants vesting at one year anniversary of option award						25.00%
Vesting period of the other grant			1 year
Percentage of stock option vesting			2.083%
Restricted stock units weighted average grant date value	$ 0.06																					$ 0.069	$ 0.06
Stock option exercises			0	0
Unrecognized compensation costs related to non-vested stock option awards			27,832,000
Forfeitures estimated			0.00%	0.00%
Restricted shares	2,987,850
Options exercisable have a weighted-average remaining contractual term			9 years 3 months 7 days	0 years
common stock for options outstanding and exercisable intrinsic value			$ 2,961,152	$ 1,000
Percentage of common stock market value used for purchase price of Employee Stock Purchase Plan			85.00%
Maximum offer period for share purchase			24 months
Shares issued under the Employee Stock Purchase Plan			0	0
Purchase of common stock, shares			0
Common stock available for future issuance			0
Maximum authorized shares									17,000
Weighted average grant-date fair values of options granted			$ 0.0598
Employee stock purchases			0	0