10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 10-Q

x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2012

OR

¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from              to             

Commission file number: 0-24274

LA JOLLA PHARMACEUTICAL COMPANY

(Exact name of registrant as specified in its charter)

California	33-0361285
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)

4370 La Jolla Village Drive, Suite 400 San Diego, CA	92122
(Address of principal executive offices)	(Zip Code)

Registrant’s telephone number, including area code: (858) 452-6600

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No  ¨

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes  x    No  ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See definition of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer	¨	Accelerated filer	¨
Non-accelerated filer	¨	Smaller reporting company	x

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes  ¨    No  x

The number of shares of the registrant’s common stock, $0.0001 par value per share, outstanding at November 2, 2012 was 13,567,383.

LA JOLLA PHARMACEUTICAL COMPANY

FORM 10-Q

QUARTERLY REPORT

INDEX

PART I – FINANCIAL INFORMATION
ITEM 1.    Condensed Financial Statements – Unaudited
Condensed Balance Sheets as of September 30, 2012 and December 31, 2011	1
Condensed Statements of Comprehensive Income (Loss) for the three and nine months ended September  30, 2012 and 2011	2
Condensed Statements of Cash Flows for the nine months ended September 30, 2012 and 2011	3
Notes to Condensed Financial Statements	4
ITEM 2.     Management’s Discussion and Analysis of Financial Condition and Results of Operations	22
ITEM 4.    Controls and Procedures	27
PART II – OTHER INFORMATION
ITEM 1A. Risk Factors	28
ITEM 6.    Exhibits	29
SIGNATURES	30

PART I. FINANCIAL INFORMATION

ITEM 1. CONDENSED FINANCIAL STATEMENTS - UNAUDITED

LA JOLLA PHARMACEUTICAL COMPANY

Condensed Balance Sheets

(in thousands, except share and par value amounts)

	September 30, 2012			December 31, 2011
	(Unaudited)			(See Note)
ASSETS
Current assets:
Cash and cash equivalents	$	3,363		$	5,040
Prepaids and other current assets		40			60
Total current assets		3,403			5,100
Total assets	$	3,403		$	5,100
LIABILITIES, REDEEMABLE CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ DEFICIT
Current liabilities:
Accounts payable	$	68		$	8
Accrued expenses		128			240
Accrued payroll and related expenses		18			7
Derivative liabilities		12,717			15,270
Total current liabilities		12,931			15,525
Series C-12 redeemable convertible preferred stock, $0.0001 par value; 11,000 shares authorized, 5,386 and 5,043 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively (redemption value and liquidation preference in the aggregate of $5,667 at September 30, 2012 and $5,116 at December 31, 2011)		5,800			5,133
Commitments and contingencies
Stockholders’ deficit:
Common stock		5			—
Preferred stock		3,595			—
Additional paid-in capital		425,333			424,071
Accumulated deficit		(444,261	)		(439,629	)
Total stockholders’ deficit		(15,328	)		(15,558	)
Total liabilities, redeemable convertible preferred stock and stockholders’ deficit	$	3,403		$	5,100

Note: The condensed balance sheet at December 31, 2011 has been derived from the audited financial statements as of that date but does not include all of the information and disclosures required by U.S. generally accepted accounting principles (see Note 1).

See accompanying notes.

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Condensed Statements of Comprehensive Income (Loss)

(Unaudited)

(in thousands, except per share amounts)

	Three Months  Ended September 30,						Nine Months  Ended September 30,
	2012			2011			2012			2011
Expenses:
Research and development	$	474		$	—		$	844		$	177
General and administrative		2,974			423			6,485			1,628
Total expenses		3,448			423			7,329			1,805
Loss from operations		(3,448	)		(423	)		(7,329	)		(1,805	)
Other income (expense):
Adjustments to fair value of derivative liabilities		1,227			3,993			2,696			3,346
Other income (expense), net		(1	)		—			1			234
Net income (loss)		(2,222	)		3,570			(4,632	)		1,775
Preferred stock dividend forfeited (earned)		(205	)		(3	)		(281	)		75
Net income (loss) and comprehensive income (loss) attributable to common stockholders	$	(2,427	)	$	3,567		$	(4,913	)	$	1,850
Net income (loss) per basic share	$	(0.18	)	$	6.69		$	(0.55	)	$	8.25
Net income (loss) per diluted share	$	(0.18	)	$	0.28		$	(0.55	)	$	0.04
Shares used in computing basic net income (loss) per share		13,253			533			8,995			224
Shares used in computing diluted net income (loss) per share		13,253			12,880			8,995			48,696

See accompanying notes.

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LA JOLLA PHARMACEUTICAL COMPANY

Condensed Statements of Cash Flows

(Unaudited)

(in thousands)

	Nine Months Ended September 30,
	2012			2011
Operating activities:
Net loss	$	(4,632	)	$	1,775
Adjustments to reconcile net loss to net cash used for operating activities:
Share-based compensation expense		5,672			194
Gain on adjustments to fair value of derivative liabilities		(2,696	)		(3,346	)
Change in operating assets and liabilities:
Prepaids and other current assets		20			58
Accounts payable		60			(16	)
Accrued expenses		(112	)		(27	)
Accrued payroll and related expenses		11			(2	)
Net cash used for operating activities		(1,677	)		(1,364	)
Net decrease in cash and cash equivalents		(1,677	)		(1,364	)
Cash and cash equivalents at beginning of period		5,040			6,866
Cash and cash equivalents at end of period	$	3,363		$	5,502
Supplemental schedule of noncash investing and financing activities:
Issuance of preferred stock		3,611			—
Conversion of preferred stock into common stock		46			748
Reclassification of preferred stock currently redeemable		—			5,532
Preferred stock dividends (earned)		(281	)		—
Payment of preferred stock dividends		(374	)		—
Forfeiture of preferred stock dividends		—			75

See accompanying notes.

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LA JOLLA PHARMACEUTICAL COMPANY

Notes to Condensed Financial Statements

(Unaudited)

September 30, 2012

1. Basis of Presentation

The accompanying unaudited condensed financial statements of La Jolla Pharmaceutical Company (the “Company”) have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 8 of Regulation S-X. Accordingly, they do not include all of the information and disclosures required by GAAP for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring accruals and valuation adjustments) considered necessary for a fair presentation have been included. Operating results for the three months ended September 30, 2012 are not necessarily indicative of the results that may be expected for other quarters or the year ending December 31, 2012. For more complete financial information, these unaudited condensed financial statements, and the notes thereto, should be read in conjunction with the audited financial statements for the year ended December 31, 2011 included in the Company’s Form 10-K filed with the Securities and Exchange Commission on March 30, 2012.

The accompanying unaudited condensed financial statements have been prepared assuming that the Company will continue as a going concern. This basis of accounting contemplates the recovery of the Company’s assets and the satisfaction of its liabilities in the normal course of business and this does not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern. While the basis of presentation remains that of a going concern, the Company has a history of recurring losses from operations and, as of September 30, 2012, the Company had no revenue sources, an accumulated deficit of $444,261,000 and available cash and cash equivalents of $3,363,000, of which $2,900,000 could be required to be paid upon the exercise of redemption rights under the Company’s outstanding preferred securities (see Note 4). Such redemption was not considered probable as of September 30, 2012. However, these factors raise substantial doubt about the Company’s ability to continue as a going concern.

On January 19, 2012, the Company entered into an Asset Purchase Agreement (the “Asset Purchase Agreement”), dated as of January 19, 2012, with Solana Therapeutics, Inc., a Delaware corporation (“Solana”). Pursuant to the Asset Purchase Agreement, the Company agreed to acquire from Solana the global development and commercialization rights and certain assets related to an investigational new drug referred to as GCS-100 (“GCS-100”), which include patents and patent rights, regulatory registrations and study drug supplies (collectively, the “Purchased Assets”). The acquisition of the Purchased Assets was completed on January 19, 2012 and the Company agreed to pay a nominal amount for the Purchased Assets at that time.

On January 19, 2012, the Company entered into a Consent and Amendment Agreement (the “Amendment Agreement”) with certain of its Series C-1¹ Convertible Preferred Stock holders to amend the terms of the Securities Purchase Agreement, dated as of May 24, 2010 (“Securities Purchase Agreement”), and the forms of Cash Warrants (as defined in the Securities Purchase Agreement) and Cashless Warrants (as defined in the Securities Purchase Agreement), as well as to adopt the Certificate of Designations, Preferences and Rights of Series C-1² Convertible Preferred Stock (“Series C-1² Stock”), Series C-2² Convertible Preferred Stock (“Series C-2² Stock”), Series D-1² Convertible Preferred Stock (“Series D-1² Stock”) and Series D-2² Convertible Preferred Stock (“Series D-2² Stock”) (the “Series C-1²/D-1² Certificate”). Under the Amendment Agreement, the Termination Date (as defined in the Cash Warrants and Cashless Warrants) was amended to extend the Termination Date to the date that is three years following the closing of the asset purchase. Additionally, the mandatory redemption provision of the Cash Warrants was removed.

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As part of the Amendment Agreement, the Company designated four new series of preferred stock on January 19, 2012: its Series C-1² Stock, Series C-2² Stock, Series D-1² Stock, and Series D-2² Stock (collectively, the “2012 New Preferred Stock”). It exchanged on a one-for-one basis each share of its existing Series C-1¹ Convertible Preferred Stock that was outstanding for a new share of Series C-1² Stock. Each holder of 2012 New Preferred Stock may convert its 2012 New Preferred Stock shares into the Company’s common stock, par value $0.0001 per share (“Common Stock”), subject to a weekly conversion cap equal to the product of the face amount of the outstanding Series C-1² Stock held by the stockholder on the Closing multiplied by the Conversion Cap (as defined in the Series C-1²/D-1² Certificate) for such week. Depending on the Volume-Weighted Closing Price, or VWCP (as defined in the Series C-1²/D-1² Certificate), for the last three Trading Days (as defined in the Series C-1²/D-1² Certificate) during the previous calendar week, the Conversion Cap can range from 0% to 3.76%. Each 2012 New Preferred Stock holder may only convert such preferred shares into common stock to the extent that after such conversion such holder owns less than 9.999% of the Company’s issued and outstanding common stock.

On the first anniversary of the Asset Purchase Agreement (i.e. January 19, 2013), the holders of Series C-1² Stock may redeem a number of shares of Series C-1² Stock equal to the lesser of (i) the entire balance of the outstanding Series C-1² Stock, or (ii) 2,900 shares of Series C-1² Stock. The 2012 New Preferred Stock also allows for redemption by its holders following the occurrence of certain other events. If the holders of Series C-1² Stock redeem a number of shares of Series C-1² Stock equal to or greater than the lesser of (i) the entire balance of the outstanding Series C-1² Stock or (ii) 2,900 shares of Series C-1² Stock, then Solana shall have the right for a period of 10 business days following the earlier of (i) or (ii) above, to elect to purchase from the Company all right, title and interest in and to the Purchased Assets, including any assets and patent rights arising from the Purchased Assets after the Closing of the asset purchase, upon repaying to the Company the nominal consideration paid pursuant to the Agreement.

2. Accounting Policies

Corporate Structure

The Company was originally incorporated in Delaware in 1989. At the annual meeting of stockholders of the Delaware company on May 22, 2012, the stockholders, upon the recommendation of the Delaware company’s board of directors, approved a proposal to merge the Delaware company with and into its wholly-owned subsidiary, LJPC Merger Sub, Inc., for the purpose of changing the domicile of the Company from Delaware to California (the “Merger”). Following stockholder approval, the Merger was effected on June 7, 2012. As a result, the Company is now a California corporation and LJPC Merger Sub, Inc. changed its name to La Jolla Pharmaceutical Company. The authorized capital stock of the Company increased from 6,008,000,000 to 12,008,000,000 shares. All common and preferred shares of the Delaware company were exchanged for common and preferred shares of the Company.

Use of Estimates

The preparation of condensed financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the unaudited condensed financial statements and disclosures made in the accompanying notes to the unaudited condensed financial statements. These include the assumptions discussed below relating to the calculation of our derivative liabilities. Actual results could differ materially from those estimates.

Recent Accounting Pronouncements

Effective January 1, 2012, the Company adopted the guidance issued by the FASB in May 2011, regarding common fair value measurements and disclosure requirements in U.S. GAAP and IFRS. This accounting standard clarifies the application of certain existing fair value measurement guidance and expands the disclosures for fair value measurements that are estimated using significant unobservable inputs. The adoption of this standard did not have a material impact on the financial position or results of operations of the Company.

Effective January 1, 2012, the Company adopted the guidance issued by the FASB in June 2011 and amended in December 2011, regarding comprehensive income. This accounting standard (1) eliminates the option

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to present the components of other comprehensive income as part of the statement of changes in stockholders’ equity; and (2) requires the consecutive presentation of the statement of net income and other comprehensive income. The amendments do not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income nor do the amendments affect how earnings per share is calculated or presented. As this accounting standard only requires enhanced disclosure, the adoption of this standard did not impact the Company’s financial position or results of operations.

Impairment of Long-Lived Assets

If indicators of impairment exist, the Company assesses the recoverability of the affected long-lived assets by determining whether the carrying value of such assets can be recovered through the undiscounted future operating cash flows.

As a result of the negative results in the confirmatory preclinical study of LJP1485 in May 2011, the Company discontinued the development of LJP1485 in May 2011 and in June 2011 the Company sold the Compounds back to GliaMed for the same nominal amount that it had paid for them. Based on these events, the future cash flows from the patents related to the Compounds were no longer expected to exceed their carrying values and the assets became impaired as of May 31, 2011. Accordingly, during the quarter ended June 30, 2011, the Company recorded a non-cash charge of $243,000 to general and administrative expense for the impairment of long-lived assets to write down the value of the Company’s patents to their estimated fair values.

Reverse Stock Split

The Board of Directors approved the reverse stock split (the “2012 Reverse Stock Split”) of the Company’s common stock, which became effective on February 17, 2012, with an exchange ratio of 1-for-100. As a result of the 2012 Reverse Stock Split, each 100 shares of the Company’s issued and outstanding common stock were automatically reclassified as and changed into one share of the Company’s common stock. No fractional shares were issued in connection with the 2012 Reverse Stock Split. Stockholders who were entitled to fractional shares instead became entitled to receive a cash payment in lieu of receiving fractional shares (after taking into account and aggregating all shares of the Company’s common stock then held by such stockholder) equal to the fractional share interest. The 2012 Reverse Stock Split affected all of the holders of the Company’s common stock uniformly. Effective on March 3, 2012, each share of 2012 New Preferred Stock was convertible into approximately 213,083 shares of common stock.

The Board of Directors approved the reverse stock split (the “2011 Reverse Stock Split”) of the Company’s common stock, which became effective on April 14, 2011, with an exchange ratio of 1-for-100. As a result of the 2011 Reverse Stock Split, each 100 shares of the Company’s issued and outstanding common stock were automatically reclassified as and changed into one share of the Company’s common stock. No fractional shares were issued in connection with the 2011 Reverse Stock Split. Stockholders who were entitled to fractional shares instead became entitled to receive a cash payment in lieu of receiving fractional shares (after taking into account and aggregating all shares of the Company’s common stock then held by such stockholder) equal to the fractional share interest. The 2011 Reverse Stock Split affected all of the holders of the Company’s common stock uniformly. Effective on May 7, 2011, each share of New Preferred Stock was convertible into approximately 166,667 shares of common stock.

All common stock share and per share information in the accompanying unaudited condensed financial statements have been restated to reflect retrospective application of the 2012 and 2011 Reverse Stock Split for all periods presented, except for par value per share and the number of authorized shares, which were not affected. Shares of the Company’s common stock underlying outstanding options and warrants were proportionately reduced and the exercise prices of outstanding options and warrants were proportionately increased in accordance with the terms of the agreements governing such securities. Shares of the Company’s common stock underlying outstanding convertible preferred stock and warrants were proportionately reduced and the conversion rates were proportionately decreased in accordance with the terms of the agreements governing such securities.

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Net Income (Loss) Per Share

Basic and diluted net income (loss) per share is computed using the weighted-average number of common shares outstanding during the periods. Basic earnings per share (“EPS”) is calculated by dividing the net income or loss by the weighted-average number of common shares outstanding for the period, without consideration for common stock equivalents. Diluted EPS is computed by dividing the net income or loss by the weighted-average number of common shares and common stock equivalents outstanding for the period issuable upon the conversion of preferred stock and exercise of stock options and warrants. These common stock equivalents are included in the calculation of diluted EPS only if their effect is dilutive (see Note 11). There is no difference between basic and diluted net loss per share for the three and nine months ended September 30, 2012, as potentially dilutive securities have been excluded from the calculation of diluted net loss per common share because the inclusion of such securities would be antidilutive.

Derivative Liabilities

In May 2010, the Company entered into definitive agreements with institutional investors and affiliates for a private placement of common stock, redeemable convertible preferred stock and warrants to purchase convertible preferred stock for initial proceeds of $6,003,000 (the “May 2010 Financing”). In conjunction with the May 2010 Financing, the Company issued redeemable convertible preferred stock that contained certain embedded derivative features, as well as warrants that are accounted for as derivative liabilities (see Note 6). These derivative liabilities were determined to be ineligible for equity classification due to certain provisions of the underlying preferred stock, which is also ineligible for equity classification, whereby redemption is outside the sole control of the Company due to provisions that may result in an adjustment to their exercise or conversion price.

The Company’s derivative liabilities were initially recorded at their estimated fair value on the date of issuance and are subsequently adjusted to reflect the estimated fair value at each period end, with any decrease or increase in the estimated fair value being recorded as other income or expense, accordingly. The fair value of these liabilities is estimated using option pricing models that are based on the individual characteristics of the common stock and preferred stock, the derivative liability on the valuation date, probabilities related to the Company’s operations and clinical development (based on industry data), as well as assumptions for volatility, remaining expected life, risk-free interest rate and, in some cases, credit spread. The option pricing models are particularly sensitive to changes in the aforementioned probabilities and the closing price per share of the Company’s common stock.

3. Fair Value of Financial Instruments

Financial assets and liabilities are measured at fair value, which is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The following is a fair value hierarchy based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value:

• Level 1 — Quoted prices in active markets for identical assets or liabilities.

• Level 2 — Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

• Level 3 — Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

As of September 30, 2012 and 2011, cash and cash equivalents were comprised of cash in checking accounts.

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In conjunction with the May 2010 Financing, the Company issued redeemable convertible preferred stock with certain embedded derivative features, as well as warrants to purchase various types of convertible preferred stock and units. These instruments are accounted for as derivative liabilities (see Note 6).

The Company used Level 3 inputs for its valuation methodology for the embedded derivative liabilities and warrant derivative liabilities. The estimated fair values were determined using a binomial option pricing model based on various assumptions (see Note 6). The Company’s derivative liabilities are adjusted to reflect their estimated fair value at each period end, with any decrease or increase in the estimated fair value being recorded in other income or expense accordingly, as adjustments to fair value of derivative liabilities.

At September 30, 2012 and December 31, 2011, the estimated fair values of the liabilities measured on a recurring basis are as follows (in thousands):

	Fair Value Measurements at September 30, 2012
	Balance at September  30, 2012		Quoted Prices in Active  Markets (Level 1)		Significant  Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Embedded derivative liabilities	$	3,900	$	—	$	—	$	3,900
Warrant derivative liabilities		8,817		—		—		8,817
Total	$	12,717	$	—	$	—	$	12,717

	Fair Value Measurements at December 31, 2011
	Balance at December 31, 2011		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Embedded derivative liabilities	$	3,680	$	—	$	—	$	3,680
Warrant derivative liabilities		11,590		—		—		11,590
Total	$	15,270	$	—	$	—	$	15,270

The following tables present the activity for liabilities measured at estimated fair value using unobservable inputs for the nine months ended September 30, 2012 and 2011 (in thousands):

	Fair Value Measurements Using Significant Unobservable Inputs (Levels 3)
	Embedded  Derivative Liabilities		Warrant  Derivative Liabilities			Total
Beginning balance at December 31, 2011	$	3,680	$	11,590		$	15,270
Adjustment to estimated fair value		77		(2,773	)		(2,696	)
Accrued dividends payable in Series C-12 Preferred		143		—			143
Ending balance at September 30, 2012	$	3,900	$	8,817		$	12,717

During the three and nine months ended September 30, 2012, the net decrease in the estimated fair value of derivative liabilities of $1,227,000 and $2,696,000 was recorded as non-cash other income in the Condensed Statements of Comprehensive Income (Loss).

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	Fair Value Measurements Using Significant Unobservable Inputs (Levels 3)
	Embedded  Derivative Liabilities			Warrant Derivative Liabilities			Total
Beginning balance at December 31, 2010	$	5,170		$	932		$	6,102
Adjustment to estimated fair value		(1,620	)		(1,726	)		(3,346	)
Decrease of the embedded derivative liabilities for preferred shares converted into common stock		(315	)		—			(315	)
Forfeited accrued dividends payable in Series C-12 Preferred		(72	)		—			(72	)
Accrued dividends payable in Series C-11 Preferred		3			—			3
Ending balance at September 30, 2011	$	3,166		$	(794	)	$	2,372

During the three and nine months ended September 30, 2011, the net decrease in the estimated fair value of derivative liabilities of $3,993,000 and $3,346,000, was recorded as non-cash other income in the Condensed Statements of Comprehensive Income (Loss).

4. Asset Purchase Agreement

As described in Note 1, the Company acquired certain assets and rights to the GCS-100 compound on January 19, 2012 from Solana in an asset purchase transaction for nominal consideration.

This asset acquisition has been accounted for in accordance with the authoritative guidance for intangible assets. The consideration paid to acquire the Purchased Assets is required to be measured at fair value and, initially, the consideration to be measured consists only of the nominal amount paid at the Closing.

The Company filed its Series C-1²/D-1² Certificate with the State of Delaware on January 20, 2012. The Series C-1²/D-1² Certificate was superseded by the Articles of Incorporation of LJPC California (the “Articles”) in connection with the Company’s reincorporation from Delaware to California. The Articles provide the holders with the following rights:

• The holders of 2012 New Preferred Stock do not have voting rights, unless required by the California General Corporation Law or as set forth below.

• Cumulative dividends are payable on the Series C-1² Stock and Series C-2² Stock (together referred to herein as the “Series C Preferred”) at a rate of 15% per annum, each accruing from the date of issuance through the date of conversion or redemption, payable semi-annually in shares of Series C-1² Stock and Series C-2² Stock, respectively. Neither the Series D-1² Stock nor the Series D-2² Stock is entitled to dividends.

• The 2012 New Preferred Stock was initially convertible into Common Stock, at a rate of 166,667 shares of Common Stock for each share of 2012 New Preferred Stock, subject to certain limitations discussed below, at the election of the holders of New Preferred Stock. The conversion rate will be adjusted for certain events, such as stock splits, stock dividends, reclassifications and recapitalizations, and the 2012 New Preferred Stock is subject to full-ratchet anti-dilution protection such that any subsequent issuance of Common Stock below the effective conversion price of the 2012 New Preferred Stock at the time of such issuance automatically adjusts the conversion price of the 2012 New Preferred Stock to such lower price. There are also limits on the amount of 2012 New Preferred Stock that can be converted and the timing of such conversions. In accordance with the Consent Agreement, after the 2012 Reverse Stock Split, the conversion ratio for the 2012 New Preferred Stock was adjusted based on the trading price of the Company’s common stock over a period of time. Accordingly, effective March 3, 2012, each share of 2012 New Preferred Stock was convertible into approximately 213,083 shares of common stock.

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• Effective with the Consent Agreement, in any week, each holder of 2012 New Preferred Stock may convert its amount of the outstanding 2012 New Preferred Stock held by the stockholder multiplied by the Conversion Cap (as defined in the Articles) for such week. Depending on the Closing Sales Prices (as defined in the Articles), the Conversion Cap can range from 0% to 3.76%. Moreover, holders of 2012 New Preferred Stock may not convert if such conversion would result in the holder or any of its affiliates beneficially owning more than 9.999% of the Company’s then issued and outstanding shares of common stock. As of September 30, 2012, 613 shares of Series C-1² Preferred had been converted into common stock.

• Upon a Liquidation Event (as defined in the Articles), no other class or series of capital stock can receive any payment unless the 2012 New Preferred Stock has first received a payment in an amount equal to $1,000 per share, plus all accrued and unpaid dividends, if applicable.

• In the event that certain actions occur without the prior written consent of the holders of 80% of the shares of 2012 New Preferred Stock and Warrants (as defined in the Securities Purchase Agreement) on an as-converted basis (the “Requisite Holders”), such as the Company’s material breach of any material representation or warranty under the Asset Purchase Agreement, a suspension of the trading of the common stock, the failure to timely deliver shares on conversion of the 2012 New Preferred Stock, the Company commences a bankruptcy proceeding, winding up, dissolution and the like, or the consummation of a Change of Control (as defined in the Articles), then the holders of the Series C-1² Preferred shall have the right, upon the delivery of a notice to the Company by the Requisite Holders, to have such shares redeemed by the Company for an amount equal to the greater of $1,000 per share, plus accrued and unpaid dividends, or the fair market value of the underlying common stock issuable upon conversion of the Series C-1² Preferred.

• In the event that the Company fails to timely deliver shares on conversion of the 2012 New Preferred Stock, under certain circumstances, the Company must pay the 2012 New Preferred Stock holder’s costs and expenses of acquiring Cover Shares (as defined in the Articles).

• Upon certain redemption events, such as the Company’s breach of covenants or material representations or warranties under the Asset Purchase Agreement, the conversion price of the 2012 New Preferred Stock decreases to 10% of the conversion price in effect immediately before such redemption event.

• So long as at least 1,000 shares of 2012 New Preferred Stock remain outstanding (or at least 3,000 shares of 2012 New Preferred Stock remain outstanding, if the Cash Warrants have been fully exercised), the Company may not take a variety of actions (such as altering the rights, powers, preferences or privileges of the 2012 New Preferred Stock so as to effect the 2012 New Preferred Stock adversely, amending any provision of the Company’s articles of incorporation, setting aside any monies for the redemption, purchase or other acquisition of, or declare or pay any dividend or make any Distribution (as defined in the Articles) or other distribution other than pursuant to the Articles or equity compensation plans, increasing the value of the Common Stock, entering into an agreement for a Strategic Transaction or Change of Control (as defined in the Articles), consummating any financing or filing a registration statement with the Securities and Exchange Commission, incurring liabilities for no consideration or for cash consideration, property, services or other exchange, or taking any action or entering into any agreement causing the Company’s Net Cash (as defined in the Articles) to fall below $2,900,000 until the date that is thirteen months from the Closing of the asset purchase) without the prior approval of the Requisite Holders.

• Subject to the approval of the Requisite Holders, 2,900 shares of the Series C-1² Stock are redeemable on, and only on, the twelve-month anniversary of the Closing of the asset purchase.

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5. GliaMed Asset Purchase

In March 2011, the Company and Jewel Merger Sub acquired assets related to certain RIL compounds from GliaMed. The Compounds were acquired pursuant to the Asset Agreement for a nominal amount, and if certain milestones noted below were met, the Company would have paid GliaMed additional consideration of up to 8,205 shares of newly designated convertible Series E Preferred, which would have been convertible into approximately 20% of the Company’s fully diluted outstanding common stock on an as-converted basis. The issuance of the shares was tied to the achievement of certain development and regulatory milestones. GliaMed was also eligible to receive a cash payment from the Company of $5,000,000 if a Compound was approved by the FDA or EMA in two or more clinical indications.

In late May 2011, the Company received final data from the Company’s clinical research organization, which showed that the predetermined study endpoints, as set forth in the Asset Agreement, were not met and that the LJP1485 compound did not show statistically significant improvement in the study endpoints as compared to vehicle (placebo).

The purchase was originally recorded as a long-term other asset for the intangible rights received related to the Compounds equal to the nominal amount paid to GliaMed plus the asset acquisition costs incurred for legal services and due diligence related to the investigation of the underlying technology. As a result of the negative results in the confirmatory preclinical study in May 2011, the Company discontinued the development of LJP1485 in May 2011 and in June 2011 the Company sold the Compounds back to GliaMed by selling all of the outstanding capital stock of Jewel Merger Sub to GliaMed for the same nominal amount that it had paid for the Compounds.

Jewel Merger Sub had no other assets or liabilities other than those relating to the Compounds and related assets and contract rights.

As part of this asset purchase, the Company designated five new series of preferred stock on March 30, 2011: its Series C-1¹ Stock, Series C-2¹ Stock, Series D-1¹ Stock, Series D-2¹ Stock (collectively, the “New Preferred Stock”) and Series E Preferred Stock. It exchanged on a one-for-one exchange ratio each share of its existing Series C-1 Preferred Stock that was outstanding for a new share of Series C-1¹ Stock. Each holder of New Preferred Stock and Series E Preferred Stock may convert its shares into common stock subject to a weekly conversion cap and certain common stock ownership limits.

6. Securities Purchase Agreement

On May 24, 2010, the Company entered into a Securities Purchase Agreement by and among the Company and the purchasers named therein (the “Purchasers”). The Purchasers included institutional investors as well as the Company’s then Chief Executive Officer and Chief Financial Officer as well as an additional Company employee at that time. The total investment by these Company employees represented less than 3% of the proceeds received by the Company in the May 2010 Financing. Pursuant to the Securities Purchase Agreement, on May 26, 2010 (the “Closing Date” or “Closing”), for total consideration of $6,003,000, the Purchasers purchased (i) an aggregate of 2,897 shares of the Company’s Common Stock, par value $0.0001 per share, at a contractually stated price of $300 per share, and (ii) 5,134 shares of the Company’s Series C-1 Preferred, par value $0.0001 per share, at a contractually stated price of $1,000 per share. The Purchasers also received (i) Series D-1 Warrants to purchase 5,134 shares of the Company’s Series D-1 Preferred, par value $0.0001 per share, at an exercise price of $1,000 per share, which warrants may be exercised on a cashless basis, and (ii) Series C-2 Warrants to purchase 10,268 units, at an exercise price of $1,000 per unit, which warrants are exercisable only in cash, with each unit consisting of one share of the Company’s Series C-2 Preferred, par value $0.0001 per share, and an additional Series D-2 Warrant to purchase one share of the Company’s Series D-2 Preferred, par value $0.0001 per share, at an exercise price of $1,000 per share.

At the Closing Date, the estimated fair value of the Series C-2 Warrants for units, Series D-1 Warrants, and the embedded derivatives included within the Series C-1 Preferred exceeded the proceeds from the May 2010 Financing of $6,003,000 (see the valuations of these derivative liabilities under the heading, “Derivative Liabilities” below). As a result, all of the proceeds were allocated to these derivative liabilities and no proceeds remained for allocation to the Common Stock and Series C-1 Preferred issued in the financing.

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In March 2011, the Company entered into the Consent Agreement that amended the terms of the Securities Purchase Agreement. Under the Consent Agreement, the holders agreed to the following, among other changes: (i) a temporary suspension of dividends on Series C-1¹ Preferred and Series C-2¹ Preferred (ii) to provide an additional cash payment of approximately $236,000 in exchange for the right to receive Series C-2¹ Preferred upon the achievement of certain pre-specified results in the preclinical study of one of the Compounds (the “Preclinical Milestone”), (iii) to increase the warrants that must be exercised for cash from 10,268 to 10,646 units, (iv) the mandatory exercise of $7,452,000 of such warrants upon the achievement of the Preclinical Milestone, (v) the mandatory exercise of the remaining $3,194,000 of warrants upon the achievement of a future clinical milestone and (vi) an automatic one-time downward conversion price adjustment following the 2011 Reverse Stock Split.

The Company filed its Series C/D Certificate and Series E Certificate (collectively, the “Certificates”) with the State of Delaware on March 30, 2011. Each Certificate provided the holders with the following rights (the Series C/D Certificate was superseded by the Series C-1²/D-1² Certificate that was filed on January 20, 2012 and the Series C-1²/D-1² Certificate was superseded by the Articles of Incorporation of LJPC California filed in connection with the Company’s reincorporation from Delaware to California):

• The holders of New Preferred Stock and Series E Preferred Stock (collectively, the “C/D/E Preferred Stock”) did not have voting rights unless required by the Delaware General Corporation Law or as set forth below.

• Cumulative dividends were payable on the Series C-1¹ Stock and Series C-2¹ Stock (together referred to herein as the “Series C¹ Preferred”) at a rate of 15% per annum and on the Series E Preferred Stock at a rate of 5% per annum, each accruing from the date of issuance through the date of conversion or redemption, payable semi-annually in shares of Series C-1¹ Stock, Series C-2¹ Stock and Series E Preferred Stock, respectively, but subject to the temporary suspension of dividends with respect to the Series C¹ Preferred, as described above. Neither the Series D-1¹ Stock nor the Series D-2¹ Stock was entitled to dividends.

• The C/D/E Preferred Stock was convertible into common stock, initially at a rate of 66,667 shares of common stock for each share of C/D/E Preferred Stock, subject to certain limitations discussed below, at the election of the holders of C/D/E Preferred Stock. The conversion rate was adjusted for certain events, such as stock splits, stock dividends, reclassifications and recapitalizations, and the New Preferred Stock was subject to full-ratchet anti-dilution protection such that any subsequent issuance of common stock below the effective conversion price of the C/D/E Preferred Stock at the time of such issuance automatically adjusts the conversion price of the C/D/E Preferred Stock to such lower price. There were also limits on the amount of C/D/E Preferred Stock that could be converted and the timing of such conversions. The New Preferred Stock could be converted starting the first Monday following the Closing of the asset purchase. The Series E Preferred Stock could not be converted until the first Monday following the achievement of the Preclinical Milestone under the Agreement.

• Upon a Liquidation Event (as defined in each Certificate), no other class or series of capital stock could receive any payment unless the New Preferred Stock has first received a payment in an amount equal to $1,000 per share, plus all accrued and unpaid dividends, if applicable. Once the New Preferred Stock received its liquidation payment, the Series E Preferred Stock was entitled to receive a payment in an amount equal to $1,000 per share, plus all accrued and unpaid dividends, if applicable.

• In the event that certain actions occurred without the prior written consent of the holders of two-thirds of the then outstanding shares of New Preferred Stock (the “Requisite Holders”), such as the Company’s material breach of any material representation or warranty under the Securities Agreement, a suspension of the trading of the Company’s common stock, the failure to timely deliver shares on conversion of the C/D/E Preferred Stock, or the consummation of a Change of Control (as defined in the Certificate of Designations), then the holders of the Series C¹ Preferred had the right, upon the delivery of a notice to the Company by the Requisite Holders, to have such shares redeemed by the Company for an amount equal to

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the greater of $1,000 per share, plus accrued and unpaid dividends, or the fair market value of the underlying common stock issuable upon conversion of the Series C¹ Preferred. The Series E Preferred Stock did not have similar redemption rights.

• Upon certain redemption events, such as the Company’s breach of covenants or material representations or warranties under the Purchase Agreement, the conversion price of the C/D/E Preferred Stock would decrease to 10% of the conversion price in effect immediately before such redemption event.

• So long as at least 1,000 shares of New Preferred Stock remained outstanding (or at least 3,000 shares of New Preferred Stock remained outstanding if the Cash Warrants had been fully exercised), the Company may not take a variety of actions (such as altering the rights, powers, preferences or privileges of the New Preferred Stock so as to effect the New Preferred Stock adversely, amending any provision of the Company’s certificate of incorporation, entering into an agreement for a Strategic Transaction or Change of Control (as each is defined in the Series C/D Certificate, and may not consummate any financing or file a registration statement with the Securities and Exchange Commission without the prior approval of the Requisite Holders. The Series E Preferred Stock did not have similar protective provisions.

In June 2011, the Company entered into the Amendment Agreement that amended the terms of the Securities Purchase Agreement and the Consent Agreement. Under the Amendment Agreement, the Holders agreed to the following, among other changes: (i) a temporary waiver of dividends on Series C-1¹ Preferred (ii) to provide additional working capital by July 29, 2011, in an amount to be determined, if the Requisite Holders (as defined in the Amendment Agreement) determined by July 22, 2011 that, as of such date, the Company was continuing to pursue a Strategic Transaction (as defined in the Amendment Agreement) (iii) to purchase up to all of the outstanding Series C-1¹ Preferred and certain warrants held by then current and former Company employees, including the executive officers at that time, who will have the right to require the Holder to purchase these securities for a limited period of time following the employee’s termination of service with the Company.

In August 2011, the Company entered into a Second Amendment Agreement that extended the terms of the Amendment Agreement through October 31, 2011. Under the Second Amendment Agreement, the Holders agreed to the following, among other changes: (i) to continue a temporary waiver of dividends on Series C-1¹ Preferred (ii) to provide additional working capital, in an amount to be determined, if the Requisite Holders (as defined in the Second Amendment Agreement) determine by September 2, 2011, and then again by September 26, 2011, that, as of such date, the Company was continuing to pursue a Strategic Transaction (as defined in the Second Amendment Agreement) (iii) to purchase up to all of the outstanding Series C-1¹ Preferred and certain warrants held by then current and former Company employees, including the executive officers at that time, who will have the right to require the Holder to purchase these securities for a limited period of time following the employee’s termination of service with the Company.

Accounting Treatment

On May 26, 2010, the Company issued 5,134 shares of Series C-1² Preferred and recorded the par value of $0.0001 per share with a corresponding reduction to paid-in capital, given that there was no allocated value from the proceeds to the Series C-1² Preferred.

Under accounting guidance covering accounting for redeemable equity instruments, preferred securities that are redeemable for cash or other assets are to be classified outside of permanent equity (within the mezzanine section between liabilities and equity on the balance sheets) if they are redeemable at the option of the holder or upon the occurrence of an event that is not solely within the control of the issuer. As there are redemption-triggering events related to the Series C-1² Preferred that are not solely within the control of the Company, the Series C-1² Preferred was classified outside of permanent equity.

The Company may be required to redeem the Series C-1² Preferred if a redemption event occurs. Since the Company did not consummate a Strategic Transaction by February 26, 2011, the Series C-1² Preferred is currently redeemable and therefore the Company adjusted the carrying value of the Series C-1² Preferred to the redemption value of such shares. The carrying value at September 30, 2012, of $5,800,000 represents the redemption value of the Series C-1² Preferred plus accrued and unpaid dividends.

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Derivative Liabilities

The Series C-1² Preferred and the underlying securities of the Series C-2² Warrants for units and Series D-1² Warrants contain conversion features. In addition, the Series C-1² Preferred and the underlying securities of the Series C-2² Warrants for units are subject to redemption provisions that are outside of the control of the Company.

The Series C-2² Warrants and Series D-1² Warrants are exercisable starting on the issuance date and expire three years from the date of issuance. The Series C-2² Warrants must be exercised in cash and, beginning in June 2011, they are no longer subject to mandatory exercise terms. The Series D-1² Warrants may be exercised on a cashless basis and are not subject to mandatory exercise terms.

Accounting Treatment

The Company accounts for the conversion and redemption features embedded in the Series C-1² Preferred (the “Embedded Derivatives”) in accordance with accounting guidance covering derivatives. Under this accounting guidance, companies may be required to bifurcate conversion and redemption features embedded in redeemable convertible preferred stock from their host instruments and account for these embedded derivatives as free standing derivative financial instruments. If the underlying security of the embedded derivative requires net cash settlement in the event of circumstances that are not solely within the Company’s control, the embedded derivative should be classified as a liability, measured at fair value at issuance and adjusted to their current fair value at each period. As there are redemption triggering events for net cash settlement for Series C-1² Preferred that are not solely within the Company’s control, and the conversion feature is a derivative, the Embedded Derivatives are classified as liabilities and are accounted for using fair value accounting at each reporting date (also see Note 3).

The Company accounts for the Series C-2² Warrants for units and Series D-1² Warrants in accordance with accounting guidance covering derivatives. If the underlying security of the warrant, a.) requires net cash settlement in the event of circumstances that are not solely within the Company’s control or if not, if they are b.) not indexed to the Company’s own stock, the warrants should be classified as liabilities, measured at fair value at issuance and adjusted to their current fair value at each period. As there are redemption triggering events for Series C-2² Preferred that are not solely within the Company’s control, and the Series D-1² Preferred are not indexed to the Company’s own stock, the Series C-2² Warrants for units and Series D-1² Warrants are classified as liabilities and are accounted for using fair value accounting at each reporting date. The Embedded Derivatives, Series C-2² Warrants for units and Series D-1² Warrants are collectively referred to as the “Derivative Liabilities”.

The estimated fair values of the Derivative Liabilities as of September 30, 2012 and December 31, 2011 are summarized as follows (in thousands):

	Fair Value Measurement at
	September 30, 2012		December 31, 2011
Embedded Derivatives of Series C-12 Preferred (including dividends paid in Series C-12 Preferred)	$	3,707	$	3,628
Embedded Derivatives of accrued dividends payable in Series C-12 Preferred		193		52
Series D-12 Warrants		571		2,539
Series C-22 Warrants for:
Series C-22 Preferred		2,782		3,785
Series D-22 Warrants		5,464		5,266
	$	12,717	$	15,270

The Derivative Liabilities were valued using binomial option pricing models with various assumptions detailed below. Due to the six month trading restriction on the unregistered shares of common stock issued or issuable from the conversion of Preferred Stock and the weekly conversion limitation on Preferred Stock as well as

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the uncertainty of the Company’s ability to continue as a going concern, the price per share of the Company’s common stock used in the binomial option pricing models for the Derivative Liabilities was discounted from the closing market prices of $0.06 and $0.27 on September 30, 2012 and December 31, 2011, respectively. The expected lives that were used to value each of the Derivative Liabilities were based on the individual characteristics of the underlying Preferred Stock, which impact the expected timing of conversion into common stock. In addition, the probabilities associated with the successful clinical development of a drug candidate based on industry data were used in each of the binomial option pricing models. The models used to value the Series C-2² Warrants and Series D-1² Warrants are particularly sensitive to such probabilities, as well as to the closing price per share of the Company’s common stock. To better estimate the fair value of the Derivative Liabilities at each reporting period, the binomial option pricing models and their inputs were refined based on information available to the Company. Such changes did not have a significant impact on amounts recorded in previous interim reporting periods.

At December 31, 2011, the total value of the Embedded Derivatives was $3,680,000. At September 30, 2012, the total value of the Embedded Derivatives was $3,900,000, resulting in non-cash other expense on the increase in the estimated fair value of the Embedded Derivatives for the nine months ended September 30, 2012 of $77,000 (exclusive of the net increase in the liability of $143,000 due to the accrual of dividends). Such increase in value was primarily due to the changes in the Company’s common stock price and adjustment to the conversion price of the preferred stock, after consideration of the 2012 Reverse Stock Split and the updates to the assumptions used in the option pricing models.

The Embedded Derivatives were valued at September 30, 2012 and December 31, 2011 using a binomial option pricing model, based on the value of the Series C-1² Preferred shares with and without embedded derivative features, with the following assumptions:

	September 30, 2012			December 31, 2011
Closing price per share of common stock	$	0.044		$	0.27
Conversion price per share	$	0.005		$	0.60
Volatility		98.2	%		88.0	%
Risk-free interest rate		0.58	%		0.83	%
Credit spread		19.8	%		20.9	%
Remaining expected lives of underlying securities (years)		4.8			5.0

On December 31, 2011, the Series D-1² Warrants were recorded at estimated fair value of $2,539,000. On September 30, 2012, the Series D-1² Warrants were revalued at $571,000 resulting in non-cash other income on the decrease in the estimated fair value of the Series D-1² Warrants of $1,968,000. Such decrease in value was primarily due to the exercise of 3,611 Series D-1² Warrants and updates to the assumptions used in the option pricing models.

The Series D-1² Warrants were valued at September 30, 2012 and December 31, 2011 using a binomial option pricing model with the following assumptions:

	September 30, 2012			December 31, 2011
Closing price per share of common stock	$	0.044		$	0.27
Conversion price per share	$	0.005		$	0.60
Volatility		74.8	%		67.5	%
Risk-free interest rate		0.23	%		0.28	%
Remaining expected lives of underlying securities (years)		2.5			2.2
Probability of Strategic Transaction		41	%		70	%

On December 31, 2011, the Series C-2² Warrants (which consist of rights to purchase Series C-2² Preferred and Series D-2² Warrants) were recorded at an estimated fair value of $9,051,000. On September 30, 2012, the Series C-2² Warrants were revalued at $8,246,000, resulting in non-cash other income on the decrease in the estimated fair value of the Series C-2² Warrants of $805,000. Such decrease in value was primarily due to the extension of the term to cover the longer clinical trial period, and the updates to the assumptions used in the option pricing models.

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The portion of the Series C-2² Warrants that represent the rights to purchase Series C-2² Preferred were valued at September 30, 2012 and December 31, 2011 using a binomial option pricing model. The pricing model determines the value of the Series C-2² Preferred at the warrant exercise date, which is assumed to be at the end of the successful Phase 2 clinical trial and subtracts the value of the Series C-2² Preferred with the exercise price. The assumptions are:

	September 30, 2012			December 31, 2011
Closing price per share of common stock	$	0.044		$	0.27
Conversion price per share	$	0.005		$	0.60
Volatility		98.2	%		88.0	%
Risk-free interest rate		0.58	%		0.83	%
Credit spread		19.8	%		20.9	%
Remaining expected lives of underlying securities (years)		4.8			5.0
Time to exercise (months)		21			24

The Series D-2² Warrants were valued at September 30, 2012 and December 31, 2011 using a binomial option pricing model with the same assumptions used in the valuation of the Series D-1² Warrants. The increase in the value of the Series D-2² Warrants for the nine months ended September 30, 2012 of $198,000 was primarily due to the updates to the assumptions used in the option pricing models.

7. Preferred Stock

Preferred Stock

As of September 30, 2012, the Company’s Board of Directors is authorized to issue 8,000,000 shares of preferred stock, with a par value of $0.0001 per share, in one or more series, of which 11,000 are designated for Series C-1² Preferred, 22,000 are designated Series C-2² Preferred, 5,134 are designated Series D-1² Preferred, and 10,868 are designated Series D-2² Preferred. During the nine months ended September 30, 2012, 4,021 Series D-1² Warrants were converted into Series D-1² Preferred, by means of a cashless exercise, resulting in the issuance of 3,611 shares of Series D-1² Preferred. Also during the nine months ended September 30, 2012, there have been 16 shares of Series D-1² Preferred and 31 shares of Series C-1² Preferred converted to common stock. As of September 30, 2012, 5,386 shares of Series C-1² Preferred Stock and 3,595 shares of Series D-1² were issued and outstanding. As of December 31, 2011, 5,043 shares of Series C-1² Preferred Stock were issued and outstanding.

8. Stockholders’ Equity

Warrants

In connection with the Company’s public offering of shares of Common Stock and warrants to purchase shares of Common Stock in May 2008, the Company issued warrants to purchase 390 shares of the Company’s Common Stock. The warrants were immediately exercisable upon grant, have an exercise price of $2,150 per share and remain exercisable for five years. As of September 30, 2012, all of these warrants were outstanding and 390 shares of common stock are reserved for issuance upon exercise of the warrants.

Share-Based Compensation

In June 1994, the Company adopted the La Jolla Pharmaceutical Company 1994 Stock Incentive Plan (the “1994 Plan”), under which, as amended, 164 shares of common stock were authorized for issuance. The 1994 Plan expired in June 2004 with no shares available for future grants, and there were 8 options outstanding under the 1994 Plan as of September 30, 2012.

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In May 2004, the Company adopted the La Jolla Pharmaceutical Company 2004 Equity Incentive Plan (the “2004 Plan”), under which, as amended, 640 shares of common stock have been authorized for issuance. The 2004 Plan provides for the grant of incentive and non-qualified stock options, as well as other share-based payment awards, to employees, directors, consultants and advisors of the Company with up to a 10-year contractual life and various vesting periods as determined by the Company’s Compensation Committee or the Board of Directors, as well as automatic fixed grants to non-employee directors of the Company. As of September 30, 2012, there were a total of 75 options outstanding under the 2004 Plan and 537 shares remained available for future grant.

In August 2010, the Company adopted the 2010 Plan. The 2010 Plan is similar to the 2004 Plan, other than with regard to the number of shares authorized for issuance. On May 22, 2012, the 2010 Plan was amended to reset the authorized number of shares for issuance to a total of 1,188,414 shares, representing 10% of the number of shares of common stock issued and outstanding on April 11, 2012 (the record date used in connection with the Company’s annual proxy). This number of shares is initially reserved for issuance and is subject to quarterly upward adjustment so that the total number of shares reserved under the 2010 Plan will, on the first day of each calendar quarter, be equal to 10% of the common stock issued and outstanding as of the last day of the prior calendar quarter. The adjustments continue through the quarter ending June 30, 2015 (resulting in a final adjustment on July 1, 2015). In no event will the number of shares potentially issuable under the 2010 Plan exceed 676,640,705, which represents 10% of the number of shares of common stock potentially outstanding on a fully-diluted and as-converted basis on April 11, 2012, after giving effect to the potential conversion of the convertible preferred stock that was issued and outstanding on April 11, 2012. Effective as of July 1, 2012, the Company authorized 47,804 additional shares for issuance based on 10% of the number of shares of common stock outstanding on June 30, 2012. As of September 30, 2012, there were a total of 16 options outstanding and 1,236,202 shares remained available for future grant. Effective as of October 1, 2012, the Company authorized 120,520 additional shares for issuance based on 10% of the number of shares of common stock outstanding on September 30, 2012.

On April 10, 2012, the Company awarded options to purchase up to 592,230,471 shares of common stock to the President and Chief Executive Officer, a board member and an employee. The inducement options were granted outside of the 2010 Plan, but they are subject to the terms and conditions of the 2010 Plan. The inducement options were granted at an exercise price of $0.06 and two of the grants vest with respect to 25% of the underlying shares on a specified one-year anniversary date, with the remainder vesting monthly, in equal monthly installments, over the three years thereafter. The grant made to a board member vests on a quarterly basis over a one-year period (see note 9).

A summary of the Company’s stock option activity and related data for the nine months ended September 30, 2012 follows:

	Outstanding Options
	Number of Shares			Weighted-Average Exercise  Price
Balance at December 31, 2011		894		$	17,462
Grant		592,230,471		$	0.06
Forfeited/Expired		(795	)	$	11,420
Balance at September 30, 2012		592,230,570		$	0.067

As of September 30, 2012, options exercisable have a weighted-average remaining contractual term of 9.53 years. No stock option exercises occurred during the year ended December 31, 2011. As of September 30, 2012 and December 31, 2011, the total intrinsic value, which is the difference between the exercise price and closing price of the Company’s common stock for options outstanding and exercisable, was $0.

	September 30, 2012				December 31, 2011
	Options		Weighted-Average Exercise Price		Options		Weighted-Average Exercise Price
Exercisable at end of period		9,453,848	$	0.5012		585	$	26,243
Weighted-average fair value of options granted during the period	$	0.06			$	—

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Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock) as of September 30, 2012 were:

Options Outstanding	Range of Exercise Prices	Weighted- Average Remaining Contractual Life (in years)	Weighted- Average Exercise Price		Options Exercisable		Weighted- Average Price of Options Exercisable
592,230,471	$0.06	9.53	$	0.06		9,453,749	$	0.06
55	$210 - $21,500	7.11	$	4,876		55	$	4,876
10	$39,900	3.63	$	39,900		10	$	39,900
11	$42,000	3.03	$	42,000		11	$	42,000
1	$52,600	3.45	$	52,600		1	$	52,600
10	$59,700	4.65	$	59,700		10	$	59,700
5	$148,000	1.64	$	148,000		5	$	148,000
2	$148,500	0.61	$	148,500		2	$	148,500
2	$235,500	0.97	$	235,500		2	$	235,500
3	$295,000	0.14	$	295,000		3	$	295,000
592,230,570	$0.06-$295,000	9.53	$	0.067		9,453,848	$	0.5012

At September 30, 2012, the Company has reserved 593,467,889 shares of common stock for future issuance upon exercise of options granted or to be granted under the 1994, 2004 and 2010 Plans, as well as for inducement options granted outside of the Company’s equity compensation plans.

The following table summarizes share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category (in thousands):

	Three Months Ended September 30,				Nine Months Ended Spetember 30,
	2012		2011		2012		2011
Research and development	$	279	$	—	$	526	$	—
General and administrative		2,683		63		5,146		194
Share-based compensation expense included in operating expenses	$	2,962	$	63	$	5,672	$	194

The Company determines the fair value of share-based payment awards on the date of grant using the Black-Scholes option-pricing model, which is affected by the Company’s stock price as well as assumptions regarding a number of highly complex and subjective variables. Option pricing models were developed for use in estimating the value of traded options that have no vesting or hedging restrictions and are fully transferable. Although the fair value of employee and director stock options granted by the Company is determined using an option pricing model, that value may not be indicative of the fair value observed in a willing-buyer/willing-seller market transaction.

The Company estimated the fair value of each option grant on the date of grant using the Black-Scholes option-pricing model with the following weighted-average assumptions:

	Three Months  Ended September 30,						Nine Months  Ended September 30,
Option:	2012			2011			2012			2011
Risk-free interest rate		—	%		—	%		1.10	%		—	%
Dividend yield		—	%		—	%		0.0	%		—	%
Volatility		—	%		—	%		236	%		—	%
Expected life (years)		—			—			6.04			—

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The remaining unamortized share-based compensation expense related to stock options as of September 30, 2012 is $30,428,000. The remaining expense of the inducement option issued to the board member totaling $444,000 will be recognized over four months, ending in January 2013. The remaining expense of the inducement options issued to the President and Chief Executive Officer and an employee totaling $29,984,000, will be recognized over approximately 40 months, ending in January 2016.

Employee Stock Purchase Plan

Effective August 1, 1995, the Company adopted the 1995 Employee Stock Purchase Plan, or ESPP, under which shares of common stock are reserved for sale to eligible employees, as defined in the ESPP. Employees may purchase common stock under the ESPP every three months (up to but not exceeding 10% of each employee’s base salary or hourly compensation, and any cash bonus paid, subject to certain limitations) over the offering period at 85% of the fair market value of the common stock at specified dates. The offering period may not exceed 24 months. At the Annual Meeting of Stockholders held on August 12, 2010, the stockholders approved an amendment to the ESPP to extend the term thereof from 2015 to 2025 and to increase the shares of common stock authorized for issuance hereunder from 85 to 485. As of September 30, 2012, 72 shares of common stock have been purchased under the ESPP and 413 shares of common stock are available for future issuance. No shares were issued under the ESPP during the year ended December 31, 2011 or for the nine months ended September 30, 2012.

Restricted Stock

In April 2012, the Company issued restricted common stock to the President and Chief Executive Officer, a board member and an employee. The shares were issued outside of the 2010 Plan but are subject to the terms and conditions of the 2010 Plan. The total restricted shares are 2,987,850 and the stock will vest as of January 19, 2013, so long as the holders of the Series C-1² Preferred have not elected to redeem their holdings (see Note 4). If the services of the holder are terminated during the vesting period, the shares are subject to a reacquisition right. No consideration is paid for the redemption of the shares under the reacquisition right, but the holder is required to return to the Company any cash dividends paid or payable with respect to the shares. The grant date fair value is the market value on the grant date multiplied by the number of shares granted and share-based compensation expense is recognized on a straight-line basis over the vesting period. The share-based compensation expense during the three months and nine months ended September 30, 2012 by expense category was $46,000 and $86,000 for general and administrative expenses and $12,000 and $23,000 for research and development expenses, respectively. The remaining unamortized share-based compensation expense to be recognized over the next four months is $70,000.

Restricted Stock Units

On April 10, 2012, the Company granted restricted stock units (“RSUs”) of 14,219 units to an employee and 10,360,892 units to a board member, where each RSU represents a contingent right to receive one share of the Company’s common stock. The RSUs are to vest according to a defined schedule in each agreement. Upon the designated vesting dates, the holders will receive common stock of the Company. The RSUs for the board member vest quarterly beginning on April 20, 2012 and ending on January 20, 2013. Twenty-five percent of the RSUs for the employee vest on January 19, 2013 with the remainder vesting monthly thereafter for 36 months.

On August 17, 2012, the Company granted RSUs of 2,700,000 units to two consultants of the Company, where each RSU represents a contingent right to receive one share of the Company’s common stock. The RSUs are to vest according to a defined schedule in each agreement. Upon the designated vesting dates, the holders will receive common stock of the Company. The RSUs for one consultant vest monthly beginning on August 20, 2012 and ending on January 20, 2012. Forty-five and one half percent (45.5%) of the RSUs for the second consultant vest on August 20, 2012 and the remainder vest monthly after that date until January 20, 2013.

Stock-based compensation cost of RSUs is measured by the market value of the Company’s common stock on the date of grant. The grant date value of awards granted is amortized on a straight-line basis over the requisite service periods of the awards, which are the vesting periods. The weighted average grant date value was $0.06 per RSU for the April 10, 2012 grants and $0.069 per RSU for the August 17, 2012 grants. The share-based compensation expense during the three months and nine months ended September 30, 2012 by expense category is

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$159,000 and $439,000 for general and administrative expenses and $55 and $151 for research and development expenses, respectively. The remaining unamortized share-based compensation expense to be recognized over the next four months is $184,000 for the board member RSUs, $702 to be recognized over the remaining service period for the employee RSUs, and $81,000 to be recognized over the remaining service period for the consultant RSUs.

9. Employment Agreements

As part of the Asset Purchase Agreement described in Note 1, the Company entered into an Employee Agreement with a new President and Chief Executive Officer on January 19, 2012. The annual base salary will be $240,000 for the first year of employment with the Company and will increase to $420,000 on the one-year anniversary of the employment start date. In addition, on April 10, 2012, an option to purchase up to 506,300,087 shares of common stock (the “First Option”) was awarded to the President and Chief Executive Officer, subject to the terms and conditions of any applicable award agreements and other restrictions and limitations generally applicable to common stock or equity awards held by Company executives or otherwise imposed by law. Subject to applicable terms and conditions, the First Option vests with respect to 25% of the underlying shares on the one-year anniversary of the employment start date, with the remainder vesting monthly, in equal monthly installments, over the three years thereafter. The First Option is exercisable at a price equal to the fair market value of a share of common stock on the date of the grant of the First Option. An additional option will be awarded to the President and Chief Executive Officer to purchase the number of shares of common stock equal to 7.5% of the Company’s fully diluted, as-converted shares on the second anniversary of the employment start date, less the number of shares subject to the First Option on the First Option grant date (the “Second Option”), and the Second Option will also be subject to the same terms and conditions as the First Option. Subject to applicable terms and conditions, 50% of the underlying shares of the Second Option will be fully vested on the date of the grant with the remainder vesting monthly, in equal monthly installments, over the two years thereafter. The Second Option will be exercisable at a price equal to the fair market value of a share of common stock on the date of the grant of the Second Option.

On January 19, 2012, effective upon the closing of the Asset Purchase Agreement, the former President and Chief Executive Officer and the former Chief Financial Officer resigned. Both of the Company’s aforementioned officers entered into separation agreements with the Company, and the Company agreed to make separation payments of $78,000 and $62,000 respectively. Further, both officers relinquished their rights to all Company stock options, whether vested or unvested.

10. 401(k) Plan

During September 2010, the Company adopted the La Jolla Pharmaceutical Company Retirement Savings Plan
(the “401(k) Plan”), which qualifies under Section 401(k) of the Internal Revenue Code of 1986, as amended (the “Code”).
The 401(k) Plan is a defined contribution plan established to provide retirement benefits for employees and is employee funded up to an elective annual deferral. The 401(k) Plan is available for all employees who have completed one year of service with the Company.

Following guidance in IRS Notice 98-52 related to the “safe harbor,” 401(k) plan method, non-highly compensated employees will receive a contribution from the Company equal to 3% of their annual salaries, as defined in the Code. Such contributions vest immediately and are paid annually following each year end. These “safe harbor” contributions by the Company were less than $8,000 for the year ended December 31, 2011. The contribution was paid during April 2012.

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11. Net Income (Loss) per Share

The following table sets forth the computation of basic and diluted EPS (in thousands, except per share amounts):

	Three Months Ended September 30,						Nine Months Ended September 30,
	2012			2011			2012			2011
Numerator
Net income (loss)	$	(2,222	)	$	3,570		$	(4,632	)	$	1,775
Preferred stock dividends forfeited (earned)		(205	)		(3	)		(281	)		75
Numerator for basic EPS – net income (loss) attributable to common stockholders		(2,427	)		3,567			(4,913	)		1,850
Effect of dilutive securities:
Preferred stock dividends		—			—			—			—
Numerator for diluted EPS – net income (loss) attributable to common stockholders	$	(2,427	)	$	3,567		$	(4,913	)	$	1,850
Denominator:
Weighted-average shares outstanding
Basic EPS		13,253			533			8,995			224
Effect of dilutive convertible preferred stock and warrants		—			12,347			—			48,472
Denominator for diluted EPS		13,253			12,880			8,995			48,696
Basic EPS	$	(0.18	)	$	6.69		$	(0.55	)	$	8.25
Diluted EPS	$	(0.18	)	$	0.28		$	(0.55	)	$	0.04

At September 30, 2012 and 2011, the potentially dilutive securities include 5.4 billion and 44 million shares, respectively, reserved for the exercise of outstanding stock options and warrants.

At September 30, 2011, potentially dilutive securities of approximately 1,249 shares reserved for the exercise of outstanding stock options and warrants for common stock were excluded from the diluted EPS computation because their effect was anti-dilutive.

The Series C-1² Preferred was convertible into 1.2 billion and 8.6 million shares at September 30, 2012 and 2011, respectively. The Series D-1² Preferred was convertible into 766 million shares at September 30, 2012.

12. Commitments and Contingencies

As of September 30, 2012, there were no material operating leases, notes payable, purchase commitments or capital leases.

The Company maintains its operations in a temporary space under a short-term arrangement.

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ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Forward-Looking Statements

The forward-looking statements in this report involve significant risks, assumptions and uncertainties, and a number of factors, both foreseen and unforeseen, could cause actual results to differ materially from our current expectations. Forward-looking statements include those that express a plan, belief, expectation, estimation, anticipation, intent, contingency, future development or similar expression. Accordingly, you should not rely upon forward-looking statements as predictions of future events. The outcome of the events described in these forward-looking statements are subject to the risks, uncertainties and other factors described in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and in the “Risk Factors” contained in our Annual Report on Form 10-K for the year ended December 31, 2011, and in other reports and registration statements that we file with the Securities and Exchange Commission from time to time and as updated in Part II, Item 1A. “Risk Factors” contained in this Quarterly Report on Form 10-Q. We expressly disclaim any intent to update forward-looking statements.

Overview

La Jolla Pharmaceutical Company (the “Company”) is a biopharmaceutical company that was originally incorporated in Delaware in 1989. At the annual meeting of stockholders of the Delaware company on May 22, 2012, the stockholders, upon the recommendation of the Delaware company’s board of directors, approved a proposal to merge the Delaware company with and into its wholly-owned subsidiary, LJPC Merger Sub, Inc., for the purpose of changing the domicile of the Company from Delaware to California (the “Merger”). Following stockholder approval, the Merger was effected on June 7, 2012. As a result, the Company is now a California corporation and LJPC Merger Sub, Inc. changed its name to La Jolla Pharmaceutical Company. The authorized capital stock of the Company increased from 6,008,000,000 to 12,008,000,000 shares. All common and preferred shares of the Delaware company were exchanged for common and preferred shares of the Company.

Historically, we focused on the development and testing of Riquent as a treatment for Lupus nephritis. Lupus is an antibody-mediated disease caused by abnormal B cell production of antibodies that attack healthy tissues. From August 2004 to February 2009, Riquent was being studied in a double-blinded multicenter Phase 3 clinical trial, called the “ASPEN” trial, which was determined to be futile in February 2009. Accordingly, the ASPEN trial and the development of Riquent were discontinued in 2009. We do not currently plan to spend any additional effort on the development of Riquent.

In March 2011, the Company and its formerly wholly-owned subsidiary, Jewel Merger Sub, Inc., acquired the rights to compounds known as Regenerative Immunophilin Ligands (“RILs” or “Compounds”) from privately held GliaMed, Inc. (“GliaMed”). The Compounds were acquired pursuant to an asset purchase agreement for a nominal amount, and if certain development and regulatory milestones were met, the Company would have paid GliaMed additional consideration consisting of up to 8,205 shares of newly designated Series E Convertible Preferred Stock, which would have been convertible into approximately 20% of the Company’s fully diluted outstanding common stock on an as-converted basis. GliaMed would have also been eligible for a potential cash payment from the Company if a Compound was approved by the Food and Drug Administration (FDA), or European Medicines Agency (EMA), in two or more clinical indications.

Following the acquisition of the Compounds, the Company initiated a confirmatory preclinical animal study in April 2011 studying the lead RIL compound, LJP1485. This study was completed in May 2011, after which the Company received final data from the Company’s clinical research organization, which data showed that the predetermined study endpoints were not met and that the LJP1485 compound did not show statistically significant improvement in the study endpoints as compared to vehicle (placebo). Due to the failure of the study, the Company halted the further development of the Compounds and GliaMed reacquired the Compounds through the purchase of the outstanding capital stock of Jewel Merger Sub, Inc. (which held title to the Compounds) for the same nominal consideration that GliaMed received at the closing of the Company’s acquisition of the Compounds.

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On January 19, 2012, we acquired rights to certain assets, including a lead clinical-stage compound designated GCS-100, from privately held Solana Therapeutics, Inc. (“Solana”), which was wholly owned by our largest holder of Series C-1² Convertible Preferred Stock. The GCS-100 compound, which inhibits the expression of galectin-3 and may represent a novel treatment for certain types of cancers and chronic organ failure, was acquired pursuant to an asset purchase agreement for nominal consideration. As a result of our acquisition of these assets, we are now focused on the development of treatments that mediate the production of galectins as a means of treating human diseases such as cancer and chronic organ failure.

GCS-100 Overview

We intend to leverage the unique biochemistry of the galectin family of proteins to pursue the development of innovative therapies to a multitude of human diseases. In particular, over-expression of galectin-3 (one member of the galectin family) has been implicated in cancer and chronic organ failure. Thus, modulation of galectin-3 activity is an attractive therapeutic target. GCS-100, our lead product, is a first-in-class inhibitor designed to sequester and eliminate circulating levels of galectin-3.

Galectins are lectins. Lectins are proteins found in the body that specifically interact with carbohydrate sugars located in, on the surface of and in between cells. This interaction causes the cells to change behavior, including cell movement, multiplication, and other cellular functions. The interactions between lectins and their target carbohydrate sugars occur via a carbohydrate recognition domain, or CRD, within the lectin. Galectins are a subfamily of lectins that have a CRD that bind specifically to b-galactoside sugar molecules. Galectins have a broad range of functions, including mediation of cell survival and adhesion, promotion of cell-cell interactions, growth of blood vessels, immune regulation and inflammation.

Over-expression of galectin-3 has been implicated in a number of human diseases including cancer and chronic organ failure. As such, this makes modulation of the activity of galectin-3 an attractive target for therapy in these diseases. Our initial programs will accordingly focus on modulation of galectin-3 in cancer using GCS-100, a complex polysaccharide that binds to and blocks the effects of galectin-3. We plan to develop GCS-100 and other inhibitors of galectin molecules as proprietary new agents subject to FDA approval.

Recent Developments

On January 19, 2012, we entered into a Consent and Amendment Agreement (the “Amendment Agreement”) with certain of our Series C-1¹ Convertible Preferred Stock holders to amend the terms of our Securities Purchase Agreement, dated as of May 24, 2010 (“Securities Purchase Agreement”), and the forms of Cash Warrants and Cashless Warrants (as defined in the Securities Purchase Agreement) initially issued under the Securities Purchase Agreement, as well as to adopt a Certificate of Designations, Preferences and Rights of Series C-1² Convertible Preferred Stock (“Series C-1² Stock”), Series C-2² Convertible Preferred Stock (“Series C-2² Stock”), Series D-1² Convertible Preferred Stock (“Series D-1² Stock”) and Series D-2² Convertible Preferred Stock (“Series D-2² Stock”) (the “Series C-1²/D-1² Certificate”). Under the Amendment Agreement, the term of the warrants was extended to the third anniversary of the acquisition of the GCS-100 assets from Solana and the warrants were amended so that they would be exercisable for shares of 2012 New Preferred Stock (defined below).

As part of the Amendment Agreement, the Company designated four new series of preferred stock on January 19, 2012: Series C-1² Stock, Series C-2² Stock, Series D-1² Stock, and Series D-2² Stock (collectively, the “2012 New Preferred Stock”). The Company exchanged, on a one-for-one basis, each share of its existing Series C-1¹ Convertible Preferred Stock that was outstanding for a new share of Series C-1² Stock. Each holder of 2012 New Preferred Stock may convert its 2012 New Preferred Stock shares into the Company’s common stock, par value $0.0001 per share (“Common Stock”), subject to a weekly conversion cap set forth in the Series C-1²/D-1² Certificate. Each 2012 New Preferred Stock holder may only convert such preferred shares into Common Stock to the extent that after such conversion such holder beneficially owns less than 9.999% of the Company’s issued and outstanding Common Stock.

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On the first anniversary of the asset purchase agreement between the Company and Solana dated January 19, 2012 (the “Asset Purchase Agreement”) (i.e., January 19, 2013), the holders of Series C-1² Stock will have a one-time right to elect to redeem a number of shares of Series C-1² Stock equal to the lesser of (i) the entire balance of the outstanding Series C-1² Stock, or (ii) 2,900 shares of Series C-1² Stock. The 2012 New Preferred Stock also allows for redemption by its holders following the occurrence of certain other events, such as a breach of the terms and conditions of the Series C-1²/D-1² Certificate. If the holders of Series C-1² Stock redeem a number of shares of Series C-1² Stock equal to or greater than the lesser of: (i) the entire balance of the outstanding Series C-1² Stock or (ii) 2,900 shares of Series C-1² Stock, then Solana shall have the right for a period of 10 business days following the earlier of (i) or (ii) above, to elect to purchase from the Company all right, title and interest in and to the GCS-100 assets, upon repaying to the Company the nominal consideration initially paid pursuant to the Asset Purchase Agreement.

As part of the Amendment Agreement, the Company agreed to implement a reverse split of the Company’s Common Stock. Pursuant to the authority delegated to the Company’s Board of Directors at a meeting of stockholders held in August 2010, the Company implemented a 1-for-100 reverse split of its Common Stock on February 17, 2012 (the “2012 Reverse Stock Split”). No fractional shares were issued and, instead, stockholders received the cash value of any fractional shares that would have been issued. Share amounts in this report are shown post-split and therefore have been adjusted to reflect the Reverse Stock Split.

Critical Accounting Policies and Estimates

The discussion and analysis of our financial condition and results of operations are based on our unaudited condensed financial statements, which have been prepared in accordance with United States generally accepted accounting principles. The preparation of these unaudited condensed financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. We evaluate our estimates on an ongoing basis. We base our estimates on historical experience and on other assumptions that we believe to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ materially from these estimates under different assumptions or conditions.

The fair value of our derivative liabilities is estimated using option pricing models that are based on the individual characteristics of the common stock and preferred stock, the derivative liability on the valuation date, probabilities related to our operations and potential clinical development (based on industry data), as well as assumptions for volatility, remaining expected life, risk-free interest rate and, in some cases, credit spread. The option pricing models of our derivative liabilities are estimates and are sensitive to changes to certain inputs used in the options pricing models. To better estimate the fair value of our derivative liabilities at each reporting period, the binomial option pricing models and their inputs were refined based on information available to the Company. Such changes did not have a significant impact on amounts recorded in previous interim reporting periods.

There have been no material changes to the critical accounting policies as previously disclosed in our Annual Report on Form 10-K for the year ended December 31, 2011 filed on March 30, 2012.

Recent Accounting Pronouncements

Effective January 1, 2012, the Company adopted the guidance issued by the Financial Accounting Standards Board, or FASB, in May 2011, regarding common fair value measurements and disclosure requirements in U.S. GAAP and IFRS. This accounting standard clarifies the application of certain existing fair value measurement guidance and expands the disclosures for fair value measurements that are estimated using significant unobservable inputs. The adoption of this standard did not have a material impact on the financial position or results of operations of the Company.

Effective January 1, 2012, the Company adopted the guidance issued by the FASB in June 2011 and amended in December 2011, regarding comprehensive income. This accounting standard (1) eliminates the option

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to present the components of other comprehensive income as part of the statement of changes in stockholders’ equity; and (2) requires the consecutive presentation of the statement of net income and other comprehensive income. The amendments do not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income nor do the amendments affect how earnings per share is calculated or presented. As this accounting standard only requires enhanced disclosure, the adoption of this standard did not impact the Company’s financial position or results of operations.

Results of Operations

There were no revenues for the three and nine months ended September 30, 2012 and 2011.

For the three and nine months ended September 30, 2012, we incurred $0.5 million and $0.8 million in research and development expense, respectively, primarily related to costs associated with preclinical studies compared to $0.0 million and $0.2 million for the same periods in 2011.

For the nine months ended September 30, 2012, general and administrative expense increased to $6.5 million, from $1.6 million for the same period in 2011. The increase is primarily the result of an increase in share-based compensation expense of $5.0 million. For the three months ended September 30, 2012, general and administrative expense was $3.0 million, compared to $0.4 million for the same period in 2011. The increase is primarily the result of an increase in share-based compensation expense of $2.6 million.

For the three months ended September 30, 2012, non-operating income as a result of adjustments to the estimated fair value of derivative liabilities was $1.2 million. The derivative liabilities issued in the May 2010 Financing were remeasured at their estimated fair value as of September 30, 2012, resulting in a net decrease in value of $1.2 million for the three months ended September 30, 2012, primarily due to the conversion of 5 shares of Series C-1² Stock into Common Stock, and changes in other inputs to the valuation models used to estimate the liabilities. This decrease in value was recorded as non-operating income.

For the three months ended September 30, 2011, non-operating income as a result of adjustments to the estimated fair value of derivative liabilities was $4.0 million. The derivative liabilities issued in the May 2010 Financing were remeasured at their estimated fair value as of September 30, 2011, resulting in a net decrease in value of $4.0 million for the three months ended September 30, 2011, primarily due to the decrease in the price per share of our Common Stock, the conversion of 185 shares of Series C-1² Stock into Common Stock, and changes in other inputs to the valuation models used to estimate the liabilities. This decrease in value was recorded as non-operating income.

For the nine months ended September 30, 2012, non-operating income as a result of adjustments to the estimated fair value of derivative liabilities was $2.7 million. The derivative liabilities issued in the May 2010 Financing were remeasured at their estimated fair value as of September 30, 2012, resulting in a net decrease in value of $2.7 million for the nine months ended September 30, 2012, primarily due to the decrease in the price per share of our Common Stock, the conversion of 25 shares of Series C-1² Stock into Common Stock, the exercise of 4,021 Series D-1² warrants and changes in other inputs to the valuation models used to estimate the liabilities. This decrease in value was recorded as non-operating income.

For the nine months ended September 30, 2011, non-operating income as a result of adjustments to the estimated fair value of derivative liabilities was $3.3 million. The derivative liabilities issued in the May 2010 Financing were remeasured at their estimated fair value as of September 30, 2011, resulting in a net decrease in value of $3.3 million for the nine months ended September 30, 2011, primarily due to the decrease in the price per share of our Common Stock, the conversion of 433 shares of Series C-1² Stock into Common Stock, and changes in other inputs to the valuation models used to estimate the liabilities. This decrease in value was recorded as non-operating income.

The non-operating income or expense as a result of adjustments to the estimated fair value of derivative liabilities is non-cash income or expense. Accounting rules require that our derivative instruments be adjusted to their fair values at each reporting date, which may cause us to report significant non-cash gains or losses as our stock price moves down or up. Prior results may not be indicative of future results.

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Liquidity and Capital Resources

From inception through September 30, 2012, we have incurred a cumulative net loss of approximately $444.3 million and have financed our operations through public and private offerings of securities, revenues from collaborative agreements, equipment financings and interest income on invested cash balances. From inception through September 30, 2012, we have raised approximately $417 million in net proceeds from sales of equity securities.

At September 30, 2012, we had $3.4 million in cash as compared to $5.0 million of cash at December 31, 2011. Of our available cash at September 30, 2012, we could be required to pay up to $2.9 million upon the redemption of our outstanding Series C-1² Stock. Such redemption was not considered probable as of September 30, 2012. Our working capital was ($9.5) million at September 30, 2012, as compared to ($10.4) million at December 31, 2011 and is largely driven by our derivative liability obligations which will likely change in value in the future. The decrease in cash resulted from the use of our financial resources to fund our general corporate operations.

In March 2011, we received funding of approximately $0.2 million from certain of our investors to defray the costs of the confirmatory preclinical study of LJP1485 at that time.

Our history of recurring losses from operations, our cumulative net loss as of September 30, 2012, and the absence of any current revenue sources raise substantial doubt about our ability to continue as a going concern.

We maintain operations in temporary space under a short-term arrangement. No notes payable, purchase commitments, capital leases or other material contractual obligations existed as of September 30, 2012.

Our current business operations are focused on using our financial resources to fund our current obligations and to develop GCS-100 and other treatments that inhibit the activity of galectins as a means of treating human diseases. We do not have adequate resources to bring our current treatments to market and will need to raise additional cash. In the future, it is possible that we will not have adequate resources to support continued operations and we will need to cease operations.

Off-Balance Sheet Arrangements

We have no off-balance sheet arrangements that have or are reasonably likely to have a current or future effect on our financial condition, changes in our financial condition, expenses, results of operations, liquidity, capital expenditures or capital resources.

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ITEM 4. CONTROLS AND PROCEDURES

Our management, with the participation of our principal executive, financial and accounting officer, evaluated the effectiveness of our disclosure controls and procedures as of September 30, 2012. The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (“Exchange Act”), means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the Securities and Exchange Commission’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the company’s management, including its principal executive, financial and accounting officer, as appropriate to allow timely decisions regarding required disclosure. Management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures. Based on the evaluation of our disclosure controls and procedures as of September 30, 2012, our principal executive, financial and accounting officer concluded that, as of such date, the Company’s disclosure controls and procedures were effective at the reasonable assurance level.

No change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) occurred during the quarter ended September 30, 2012 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

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PART II. OTHER INFORMATION

ITEM 1A. Risk Factors

I. RISK FACTORS RELATING TO THE COMPANY.

We have only limited assets and we have limits under our charter on our ability to fully spend the cash assets that we currently have.

As of September 30, 2012, we had no revenue sources, an accumulated deficit of $444.0 million and available cash and cash equivalents of $3.4 million, of which, at that time, up to $2.9 million could be required to be paid upon the triggering of a redemption right under our outstanding Series C-1² Stock including accrued dividends. Although we acquired the GCS-100 patent estate in January 2012 for nominal consideration and we retain the rights (to the extent not forfeited) to the Riquent patent estate, the values of these assets are highly uncertain and Riquent has been written down under United States generally accepted accounting principles to nearly zero. As a result, we have only limited assets available to operate and develop our business. We are utilizing a portion of our existing cash balances to conduct future clinical study of GCS-100 and to evaluate whether or not GCS-100 should be developed further. If we determine that GCS-100 does not warrant further development and the investors redeem their Series C-1² Stock, we would have only limited cash and would likely be forced to liquidate the Company. In that event, the funds resulting from the liquidation of our assets, net of amounts payable, would likely return only a small amount, if anything, to our stockholders.

Additionally, the Articles contain a term that, for a period of one year, purports to render ultra vires any transaction in which the Company causes its net cash balance to fall below $2.9 million. Thus, if the Company authorizes any expenditure or enters into any contract whereby the Company’s cash balance falls below this threshold, it is possible that a court could find that the Company did not have the requisite corporate authority to take such action. Accordingly, the Company intends to limit its overall expenditures through February 2013 so that it maintains this minimum balance. As a result, the Company effectively has only $0.5 million available for the maintenance of operations and development of GCS-100 for the period of September 2012 through February 2013.

II. RISK FACTORS RELATED SPECIFICALLY TO OUR STOCK.

We currently have 13.6 million shares of Common Stock outstanding and currently may be required to issue up to 7.4 billion shares of Common Stock upon conversion of existing preferred stock and preferred stock warrants. Such an issuance would be significantly dilutive to our existing common stockholders.

Upon the closing of the May 2010 Financing, the Company issued to investors approximately 5,134 shares of Series C-1² Stock. In light of the conversion ratio of our preferred stock (213,083 shares of Common Stock underlying every one share of Series C-1² Stock), the issuance of such a large number of preferred shares diluted the ownership of our existing stockholders and provided the new investors with a sizeable interest in the Company. These investors also received warrants to purchase shares of other series of preferred stock that may also be converted into Common Stock at a rate of 213,083 shares of Common Stock for every share of preferred stock held.

Giving effect to the potential exercise of the outstanding preferred warrants, and assuming the conversion of all preferred stock into Common Stock at the current conversion rate, we would have approximately 7.4 billion shares of Common Stock issued and outstanding, although the issuance of the Common Stock upon the conversion of our preferred stock is limited by a 9.999% beneficial ownership cap for each preferred stockholder. With approximately 13.6 million shares of Common Stock issued and outstanding as of the date of this report, the issuance of this number of shares of Common Stock underlying the preferred stock would represent approximately 99.8% dilution to our existing stockholders. It is possible that our current stock price does not reflect our fully-diluted and as-converted capital structure, which means that the conversion of preferred stock into Common Stock could significantly reduce our stock price.

28

ITEM 6. EXHIBITS

Exhibit Number	Description
31.1	Certification Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
32.1	Certification Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
101.INS	XBRL Instance Document
101.SCH	XBRL Taxonomy Extension Schema Document
101.CAL	XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF	XBRL Taxonomy Extension Definition Linkbase Document
101.LAB	XBRL Taxonomy Extension Label Linkbase Document
101.PRE	XBRL Taxonomy Extension Presentation Linkbase Document

29

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	La Jolla Pharmaceutical Company
Date: November 9, 2012	/s/ George Tidmarsh
	George Tidmarsh, M.D., Ph.D.
	President, Chief Executive Officer and
	Secretary (As Principal Executive, Financial
	and Accounting Officer)

30

EX-31.1

EXHIBIT 31.1

SECTION 302 CERTIFICATION

I, George Tidmarsh, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of La Jolla Pharmaceutical Company;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 9, 2012

/s/     George Tidmarsh

George Tidmarsh, M.D., Ph.D.

President, Chief Executive Officer and

Secretary (Principal Executive, Financial

and Accounting Offier)

EX-32.1

EXHIBIT 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

The undersigned, in his capacity as an officer of La Jolla Pharmaceutical Company (the “Registrant”), hereby certifies, for purposes of 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

• the Quarterly Report of the Registrant on Form 10-Q for the quarter ended September 30, 2012 (the “Report”), which accompanies this certification, fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

• the information contained in the Report fairly presents, in all material respects, the financial condition of the Registrant at the end of such quarter and the results of operations of the Registrant for such quarter.

Dated: November 9, 2012

/s/    George Tidmarsh

George Tidmarsh, M.D., Ph.D.

President, Chief Executive Officer and Secretary

(Principal Executive, Financial and

Accounting Officer)

Note: A signed original of this written statement required by Section 906 has been provided to La Jolla Pharmaceutical Company and will be retained by La Jolla Pharmaceutical Company and furnished to the Securities and Exchange Commission or its staff upon request.

XML

Stockholders' Equity (Details 3) (USD $)	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category
Share-based compensation expense	$ 2,962,000	$ 63,000	$ 5,672,000	$ 194,000
Research and development [Member]
Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category
Share-based compensation expense	279,000		526,000
General and administrative [Member]
Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category
Share-based compensation expense	$ 2,683,000	$ 63,000	$ 5,146,000	$ 194,000

XML

Commitments and Contingencies (Details) (USD $)	Sep. 30, 2012
Commitments and Contingencies (Textual) [Abstract]
Material operating leases	$ 0
Notes payable	0
Purchase commitment and operating lease	$ 0

XML

Securities Purchase Agreement (Details 3) (Series C-2 Warrants [Member], USD $)	Sep. 30, 2012	Dec. 31, 2011
Series C-2 Warrants [Member]
Series C2 warrants using binomial option pricing
Closing price per share of common stock	$ 0.044	$ 0.27
Conversion price per share	$ 0.005	$ 0.60
Volatility	98.20%	88.00%
Risk-free interest rate	0.58%	0.83%
Credit spread	19.80%	20.90%
Remaining expected lives of underlying securities (years)	4 years 9 months 18 days	5 years
Time to exercise (months)	21 months	24 months

XML

Fair Value of Financial Instruments (Details) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Estimated fair values of the liabilities measured on a recurring basis
Total	$ 12,717	$ 15,270
Fair Value, Measurements, Recurring [Member]
Estimated fair values of the liabilities measured on a recurring basis
Embedded derivative liabilities	3,900	3,680
Warrant derivative liabilities	8,817	11,590
Total	12,717	15,270
Quoted Prices in Active Markets -( Level 1) [Member] | Fair Value, Measurements, Recurring [Member]
Estimated fair values of the liabilities measured on a recurring basis
Embedded derivative liabilities
Warrant derivative liabilities
Total
Significant Other Observable Inputs - (Level 2) [Member] | Fair Value, Measurements, Recurring [Member]
Estimated fair values of the liabilities measured on a recurring basis
Embedded derivative liabilities
Warrant derivative liabilities
Total
Significant Unobservable Inputs - (Level 3) [Member] | Fair Value, Measurements, Recurring [Member]
Estimated fair values of the liabilities measured on a recurring basis
Embedded derivative liabilities	3,900	3,680
Warrant derivative liabilities	8,817	11,590
Total	$ 12,717	$ 15,270

XML

Employment Agreements (Details) (USD $)	9 Months Ended				9 Months Ended		9 Months Ended
	Sep. 30, 2012	Jan. 19, 2012	Jan. 19, 2012 Chief Executive Officer [Member]	Jan. 19, 2012 Chief Financial Officer [Member]	Sep. 30, 2012 First Option [Member]	Apr. 10, 2012 First Option [Member]	Sep. 30, 2012 Second Option [Member]
Employment Agreements (Textual) [Abstract]
Option to purchase shares of common stock						506,300,087
Employment start date, with the remainder vesting monthly					Over the three years		Over the two years
Separation payment to former officers on Asset Purchase Agreement			$ 78,000	$ 62,000
Employment Agreements (Additional Textual) [Abstract]
Annual base salary for first year of employment		240,000
Increase in annual base salary for second year of employment		$ 420,000
Percentage of underlying shares on one-year anniversary of the employment	25.00%
Purchase of common stock fully diluted converted shares	7.50%
Percentage of fully vested underlying shares	50.00%

XML

Stockholders' Equity (Details 1) (USD $)	9 Months Ended
	Sep. 30, 2012	Dec. 31, 2011
Schedule of share based compensation related to options exercisable and weighted average
Options, Exercisable at end of period	9,453,848	585
Weighted-Average Exercise Price, Exercisable at end of period	$ 0.5012	$ 26,243
Weighted average fair value of options granted during the period	$ 0.06

XML

Asset Purchase Agreement

9 Months Ended

Sep. 30, 2012

Asset Purchase Agreement [Abstract]

Asset Purchase Agreement

4. Asset Purchase Agreement

As described in Note 1, the Company acquired certain assets and rights to the GCS-100 compound on January 19, 2012 from Solana in an asset purchase transaction for nominal consideration.

This asset acquisition has been accounted for in accordance with the authoritative guidance for intangible assets. The consideration paid to acquire the Purchased Assets is required to be measured at fair value and, initially, the consideration to be measured consists only of the nominal amount paid at the Closing.

The Company filed its Series C-1 ²/D-1 ² Certificate with the State of Delaware on January 20, 2012. The Series C-1 ²/D-1 ² Certificate was superseded by the Articles of Incorporation of LJPC California (the “Articles”) in connection with the Company’s reincorporation from Delaware to California. The Articles provide the holders with the following rights:

• The holders of 2012 New Preferred Stock do not have voting rights, unless required by the California General Corporation Law or as set forth below.

• Cumulative dividends are payable on the Series C-1 ² Stock and Series C-2 ² Stock (together referred to herein as the “Series C Preferred”) at a rate of 15% per annum, each accruing from the date of issuance through the date of conversion or redemption, payable semi-annually in shares of Series C-1 ² Stock and Series C-2 ² Stock, respectively. Neither the Series D-1 ² Stock nor the Series D-2 ² Stock is entitled to dividends.

• The 2012 New Preferred Stock was initially convertible into Common Stock, at a rate of 166,667 shares of Common Stock for each share of 2012 New Preferred Stock, subject to certain limitations discussed below, at the election of the holders of New Preferred Stock. The conversion rate will be adjusted for certain events, such as stock splits, stock dividends, reclassifications and recapitalizations, and the 2012 New Preferred Stock is subject to full-ratchet anti-dilution protection such that any subsequent issuance of Common Stock below the effective conversion price of the 2012 New Preferred Stock at the time of such issuance automatically adjusts the conversion price of the 2012 New Preferred Stock to such lower price. There are also limits on the amount of 2012 New Preferred Stock that can be converted and the timing of such conversions. In accordance with the Consent Agreement, after the 2012 Reverse Stock Split, the conversion ratio for the 2012 New Preferred Stock was adjusted based on the trading price of the Company’s common stock over a period of time. Accordingly, effective March 3, 2012, each share of 2012 New Preferred Stock was convertible into approximately 213,083 shares of common stock.

• Effective with the Consent Agreement, in any week, each holder of 2012 New Preferred Stock may convert its amount of the outstanding 2012 New Preferred Stock held by the stockholder multiplied by the Conversion Cap (as defined in the Articles) for such week. Depending on the Closing Sales Prices (as defined in the Articles), the Conversion Cap can range from 0% to 3.76%. Moreover, holders of 2012 New Preferred Stock may not convert if such conversion would result in the holder or any of its affiliates beneficially owning more than 9.999% of the Company’s then issued and outstanding shares of common stock. As of September 30, 2012, 613 shares of Series C-1² Preferred had been converted into common stock.

• Upon a Liquidation Event (as defined in the Articles), no other class or series of capital stock can receive any payment unless the 2012 New Preferred Stock has first received a payment in an amount equal to $1,000 per share, plus all accrued and unpaid dividends, if applicable.

• In the event that certain actions occur without the prior written consent of the holders of 80% of the shares of 2012 New Preferred Stock and Warrants (as defined in the Securities Purchase Agreement) on an as-converted basis (the “Requisite Holders”), such as the Company’s material breach of any material representation or warranty under the Asset Purchase Agreement, a suspension of the trading of the common stock, the failure to timely deliver shares on conversion of the 2012 New Preferred Stock, the Company commences a bankruptcy proceeding, winding up, dissolution and the like, or the consummation of a Change of Control (as defined in the Articles), then the holders of the Series C-1² Preferred shall have the right, upon the delivery of a notice to the Company by the Requisite Holders, to have such shares redeemed by the Company for an amount equal to the greater of $1,000 per share, plus accrued and unpaid dividends, or the fair market value of the underlying common stock issuable upon conversion of the Series C-1 ² Preferred.

• In the event that the Company fails to timely deliver shares on conversion of the 2012 New Preferred Stock, under certain circumstances, the Company must pay the 2012 New Preferred Stock holder’s costs and expenses of acquiring Cover Shares (as defined in the Articles).

• Upon certain redemption events, such as the Company’s breach of covenants or material representations or warranties under the Asset Purchase Agreement, the conversion price of the 2012 New Preferred Stock decreases to 10% of the conversion price in effect immediately before such redemption event.

• So long as at least 1,000 shares of 2012 New Preferred Stock remain outstanding (or at least 3,000 shares of 2012 New Preferred Stock remain outstanding, if the Cash Warrants have been fully exercised), the Company may not take a variety of actions (such as altering the rights, powers, preferences or privileges of the 2012 New Preferred Stock so as to effect the 2012 New Preferred Stock adversely, amending any provision of the Company’s articles of incorporation, setting aside any monies for the redemption, purchase or other acquisition of, or declare or pay any dividend or make any Distribution (as defined in the Articles) or other distribution other than pursuant to the Articles or equity compensation plans, increasing the value of the Common Stock, entering into an agreement for a Strategic Transaction or Change of Control (as defined in the Articles), consummating any financing or filing a registration statement with the Securities and Exchange Commission, incurring liabilities for no consideration or for cash consideration, property, services or other exchange, or taking any action or entering into any agreement causing the Company’s Net Cash (as defined in the Articles) to fall below $2,900,000 until the date that is thirteen months from the Closing of the asset purchase) without the prior approval of the Requisite Holders.

• Subject to the approval of the Requisite Holders, 2,900 shares of the Series C-1 ² Stock are redeemable on, and only on, the twelve-month anniversary of the Closing of the asset purchase.

XML

401(K) Plan (Details) (USD $)	9 Months Ended		12 Months Ended
	Sep. 30, 2012	Sep. 30, 2012 Safe Harbor Plan [Member]	Dec. 31, 2011 Safe Harbor Plan [Member] Maximum [Member]
401(k) Plan (Textual) [Abstract]
Percentage of employee salaries paid as contribution	3.00%
Safe harbor contributions by Company			$ 8,000
401(k) Plan required eligibility service period		One year of service with the Company

XML

GliaMed Asset Purchase (Details Textual) (USD $)	Mar. 31, 2011
GliaMed Asset Purchase (Textual) [Abstract]
Percentage of fully diluted outstanding common stock	20.00%
Cash payment for assets acquired	$ 5,000,000
Series E Preferred Stock [Member]
GliaMed Asset Purchase (Textual) [Abstract]
Number of additional consideration of preferred shares in contingency	8,205

XML

Asset Purchase Agreement (Details) (USD $)	9 Months Ended			9 Months Ended
	Sep. 30, 2012	Mar. 03, 2012	May 07, 2011	Sep. 30, 2012 Maximum [Member]	Sep. 30, 2012 Minimum [Member]	Sep. 30, 2012 Series C-1 Preferred Stock [Member]	Dec. 31, 2011 Series C-1 Preferred Stock [Member]
Asset Purchase Agreement (Textual) [Abstract]
Redemption of stock						2,900
Preferred stock outstanding					1,000		5,043
Conversion Cap of Preferred Stock				3.76%	0.00%
Minimum preferred stock outstanding if warrants are exercised					3,000
Asset Purchase Agreement (Additional Textual) [Abstract]
Cumulative dividends payable rate	15.00%
Conversion of Preferred Stock into Common Stock	613	213,083	166,667
Percentage of issued and outstanding common stock	9.999%
Payment received on Preferred Stock including accrued and unpaid dividends	$ 1,000
Required percentage of approval by Preferred Stock and Warrant holders	80.00%
Decrease in Preferred Stock conversion price	10.00%
Threshold of cash to be remained outstanding, net	$ 2,900,000
Series C-1 and D-1 certificate filing date with state of Delaware	Jan. 20, 2012

XML

Net Income (Loss) per Share (Details) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Numerator
Net income (loss)	$ (2,222)	$ 3,570	$ (4,632)	$ 1,775
Preferred stock dividend forfeited (earned)	(205)	(3)	(281)	75
Numerator for basic EPS net income (loss) attributable to common stockholders	(2,427)	3,567	(4,913)	1,850
Effect of dilutive securities:
Preferred stock dividends
Numerator for diluted EPS - net income (loss) attributable to common stockholders	$ (2,427)	$ 3,567	$ (4,913)	$ 1,850
Weighted-average shares outstanding:
Basic EPS	13,253	533	8,995	224
Effect of dilutive convertible preferred stock and warrants		12,347		48,472
Denominator for diluted EPS	13,253	12,880	8,995	48,696
Basic EPS	$ (0.18)	$ 6.69	$ (0.55)	$ 8.25
Diluted EPS	$ (0.18)	$ 0.28	$ (0.55)	$ 0.04

XML

Securities Purchase Agreement (Details) (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Fair values of derivative liabilities
Derivative liabilities	$ 12,717	$ 15,270
Series D-1 Warrants [Member]
Fair values of derivative liabilities
Derivative liabilities	571	2,539
Series D-2 Warrants [Member]
Fair values of derivative liabilities
Derivative liabilities	5,464	5,266
Embedded Derivatives of Series C-1 Preferred (including dividends paid in Series C-12 Preferred) [Member]
Fair values of derivative liabilities
Derivative liabilities	3,707	3,628
Embedded Derivatives of accrued dividends payable in Series C-1 Preferred [Member]
Fair values of derivative liabilities
Derivative liabilities	193	52
Series C-2 Preferred [Member]
Fair values of derivative liabilities
Derivative liabilities	$ 2,782	$ 3,785

XML

Securities Purchase Agreement (Details 1) (Series C-1 Preferred Stock [Member], USD $)	Sep. 30, 2012	Dec. 31, 2011
Series C-1 Preferred Stock [Member]
Embedded Derivatives
Closing price per share of common stock	$ 0.044	$ 0.27
Conversion price per share	$ 0.005	$ 0.60
Volatility	98.20%	88.00%
Risk-free interest rate	0.58%	0.83%
Credit spread	19.80%	20.90%
Remaining expected lives of underlying securities (years)	4 years 9 months 18 days	5 years

XML

Fair Value of Financial Instruments

9 Months Ended

Sep. 30, 2012

Fair Value of Financial Instruments [Abstract]

Fair Value of Financial Instruments

3. Fair Value of Financial Instruments

Financial assets and liabilities are measured at fair value, which is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The following is a fair value hierarchy based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value:

• Level 1 — Quoted prices in active markets for identical assets or liabilities.

• Level 2 — Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

• Level 3 — Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

As of September 30, 2012 and 2011, cash and cash equivalents were comprised of cash in checking accounts.

In conjunction with the May 2010 Financing, the Company issued redeemable convertible preferred stock with certain embedded derivative features, as well as warrants to purchase various types of convertible preferred stock and units. These instruments are accounted for as derivative liabilities (see Note 6).

The Company used Level 3 inputs for its valuation methodology for the embedded derivative liabilities and warrant derivative liabilities. The estimated fair values were determined using a binomial option pricing model based on various assumptions (see Note 6). The Company’s derivative liabilities are adjusted to reflect their estimated fair value at each period end, with any decrease or increase in the estimated fair value being recorded in other income or expense accordingly, as adjustments to fair value of derivative liabilities.

At September 30, 2012 and December 31, 2011, the estimated fair values of the liabilities measured on a recurring basis are as follows (in thousands):

	Fair Value Measurements at September 30, 2012
	Balance at September  30, 2012		Quoted Prices in Active  Markets (Level 1)		Significant  Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Embedded derivative liabilities	$	3,900	$	—	$	—	$	3,900
Warrant derivative liabilities		8,817		—		—		8,817
Total	$	12,717	$	—	$	—	$	12,717

	Fair Value Measurements at December 31, 2011
	Balance at December 31, 2011		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Embedded derivative liabilities	$	3,680	$	—	$	—	$	3,680
Warrant derivative liabilities		11,590		—		—		11,590
Total	$	15,270	$	—	$	—	$	15,270

The following tables present the activity for liabilities measured at estimated fair value using unobservable inputs for the nine months ended September 30, 2012 and 2011 (in thousands):

	Fair Value Measurements Using Significant Unobservable Inputs (Levels 3)
	Embedded  Derivative Liabilities		Warrant  Derivative Liabilities			Total
Beginning balance at December 31, 2011	$	3,680	$	11,590		$	15,270
Adjustment to estimated fair value		77		(2,773	)		(2,696	)
Accrued dividends payable in Series C-1 2 Preferred		143		—			143
Ending balance at September 30, 2012	$	3,900	$	8,817		$	12,717

During the three and nine months ended September 30, 2012, the net decrease in the estimated fair value of derivative liabilities of $1,227,000 and $2,696,000 was recorded as non-cash other income in the Condensed Statements of Comprehensive Income (Loss).

	Fair Value Measurements Using Significant Unobservable Inputs (Levels 3)
	Embedded  Derivative Liabilities			Warrant Derivative Liabilities			Total
Beginning balance at December 31, 2010	$	5,170		$	932		$	6,102
Adjustment to estimated fair value		(1,620	)		(1,726	)		(3,346	)
Decrease of the embedded derivative liabilities for preferred shares converted into common stock		(315	)		—			(315	)
Forfeited accrued dividends payable in Series C-1 2 Preferred		(72	)		—			(72	)
Accrued dividends payable in Series C-1 1 Preferred		3			—			3
Ending balance at September 30, 2011	$	3,166		$	(794	)	$	2,372

During the three and nine months ended September 30, 2011, the net decrease in the estimated fair value of derivative liabilities of $3,993,000 and $3,346,000, was recorded as non-cash other income in the Condensed Statements of Comprehensive Income (Loss).

XML

Securities Purchase Agreement (Details 2) (Series D-1 Warrants [Member], USD $)	Sep. 30, 2012	Dec. 31, 2011
Series D-1 Warrants [Member]
Series D1 warrants using binomial option pricing
Closing price per share of common stock	$ 0.044	$ 0.27
Conversion price per share	$ 0.005	$ 0.60
Volatility	74.80%	67.50%
Risk-free interest rate	0.23%	0.28%
Remaining expected lives of underlying securities (years)	2 years 6 months	2 years 2 months 12 days
Probability of Strategic Transaction	41.00%	70.00%

XML

Stockholders' Equity (Details 4) (Stock Options [Member])	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Stock Options [Member]
Fair value of each option grant on the date of grant using the Black-Scholes option-pricing model
Risk-free interest rate	0.00%	0.00%	1.10%	0.00%
Dividend yield	0.00%	0.00%	0.00%	0.00%
Volatility	0.00%	0.00%	236.00%	0.00%
Expected life (years)	0 years	0 years	6 years 15 days	0 years

XML

Condensed Balance Sheets (USD $) In Thousands, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Current assets:
Cash and cash equivalents	$ 3,363	$ 5,040
Prepaids and other current assets	40	60
Total current assets	3,403	5,100
Total assets	3,403	5,100
Current liabilities:
Accounts payable	68	8
Accrued expenses	128	240
Accrued payroll and related expenses	18	7
Derivative liabilities	12,717	15,270
Total current liabilities	12,931	15,525
Series C-12 redeemable convertible preferred stock, $0.0001 par value; 11,000 shares authorized, 5,386 and 5,043 shares issued and outstanding at September 30, 2012 and December 31, 2011, respectively (redemption value and liquidation preference in the aggregate of $ 5,667 at September 30, 2012 and $5,116 at December 31, 2011)	5,800	5,133
Commitments and contingencies
Stockholders' deficit:
Common stock	5
Preferred stock	3,595
Additional paid-in capital	425,333	424,071
Accumulated deficit	(444,261)	(439,629)
Total stockholders' deficit	(15,328)	(15,558)
Total liabilities, redeemable convertible preferred stock and stockholders' deficit	$ 3,403	$ 5,100

XML

Net Income (Loss) per Share (Details Textual)	9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011
Net Income (Loss) per Share (Additional Textual) [Abstract]
Potentially dilutive securities for the exercise of outstanding stock options and warrants for common stock	5,400,000,000	44,000,000
Potentially dilutive securities for the exercise of outstanding stock options and warrants for common stock excluded from EPS		1,249
Series C-1 Preferred [Member]
Net Income (Loss) per Share (Textual) [Abstract]
Shares of Series C1 Preferred into common stock	1,200,000,000	8,600,000
Series D-1 Preferred [Member]
Net Income (Loss) per Share (Textual) [Abstract]
Shares of Series C1 Preferred into common stock	766,000,000

XML

Basis of Presentation

9 Months Ended

Sep. 30, 2012

Basis of Presentation [Abstract]

Basis of Presentation

1. Basis of Presentation

The accompanying unaudited condensed financial statements of La Jolla Pharmaceutical Company (the “Company”) have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 8 of Regulation S-X. Accordingly, they do not include all of the information and disclosures required by GAAP for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring accruals and valuation adjustments) considered necessary for a fair presentation have been included. Operating results for the three months ended September 30, 2012 are not necessarily indicative of the results that may be expected for other quarters or the year ending December 31, 2012. For more complete financial information, these unaudited condensed financial statements, and the notes thereto, should be read in conjunction with the audited financial statements for the year ended December 31, 2011 included in the Company’s Form 10-K filed with the Securities and Exchange Commission on March 30, 2012.

The accompanying unaudited condensed financial statements have been prepared assuming that the Company will continue as a going concern. This basis of accounting contemplates the recovery of the Company’s assets and the satisfaction of its liabilities in the normal course of business and this does not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern. While the basis of presentation remains that of a going concern, the Company has a history of recurring losses from operations and, as of September 30, 2012, the Company had no revenue sources, an accumulated deficit of $444,261,000 and available cash and cash equivalents of $3,363,000, of which $2,900,000 could be required to be paid upon the exercise of redemption rights under the Company’s outstanding preferred securities (see Note 4). Such redemption was not considered probable as of September 30, 2012. However, these factors raise substantial doubt about the Company’s ability to continue as a going concern.

On January 19, 2012, the Company entered into an Asset Purchase Agreement (the “Asset Purchase Agreement”), dated as of January 19, 2012, with Solana Therapeutics, Inc., a Delaware corporation (“Solana”). Pursuant to the Asset Purchase Agreement, the Company agreed to acquire from Solana the global development and commercialization rights and certain assets related to an investigational new drug referred to as GCS-100 (“GCS-100”), which include patents and patent rights, regulatory registrations and study drug supplies (collectively, the “Purchased Assets”). The acquisition of the Purchased Assets was completed on January 19, 2012 and the Company agreed to pay a nominal amount for the Purchased Assets at that time.

On January 19, 2012, the Company entered into a Consent and Amendment Agreement (the “Amendment Agreement”) with certain of its Series C-1 ¹ Convertible Preferred Stock holders to amend the terms of the Securities Purchase Agreement, dated as of May 24, 2010 (“Securities Purchase Agreement”), and the forms of Cash Warrants (as defined in the Securities Purchase Agreement) and Cashless Warrants (as defined in the Securities Purchase Agreement), as well as to adopt the Certificate of Designations, Preferences and Rights of Series C-1² Convertible Preferred Stock (“Series C-1² Stock”), Series C-2² Convertible Preferred Stock (“Series C-2² Stock”), Series D-1² Convertible Preferred Stock (“Series D-1² Stock”) and Series D-2² Convertible Preferred Stock (“Series D-2² Stock”) (the “Series C-1² /D-1² Certificate”). Under the Amendment Agreement, the Termination Date (as defined in the Cash Warrants and Cashless Warrants) was amended to extend the Termination Date to the date that is three years following the closing of the asset purchase. Additionally, the mandatory redemption provision of the Cash Warrants was removed.

As part of the Amendment Agreement, the Company designated four new series of preferred stock on January 19, 2012: its Series C-1 ² Stock, Series C-2 ² Stock, Series D-1 ² Stock, and Series D-2 ² Stock (collectively, the “2012 New Preferred Stock”). It exchanged on a one-for-one basis each share of its existing Series C-1¹ Convertible Preferred Stock that was outstanding for a new share of Series C-1² Stock. Each holder of 2012 New Preferred Stock may convert its 2012 New Preferred Stock shares into the Company’s common stock, par value $0.0001 per share (“Common Stock”), subject to a weekly conversion cap equal to the product of the face amount of the outstanding Series C-1² Stock held by the stockholder on the Closing multiplied by the Conversion Cap (as defined in the Series C-1² /D-1² Certificate) for such week. Depending on the Volume-Weighted Closing Price, or VWCP (as defined in the Series C-1²/D-1 ² Certificate), for the last three Trading Days (as defined in the Series C-1²/D-1 ² Certificate) during the previous calendar week, the Conversion Cap can range from 0% to 3.76%. Each 2012 New Preferred Stock holder may only convert such preferred shares into common stock to the extent that after such conversion such holder owns less than 9.999% of the Company’s issued and outstanding common stock.

On the first anniversary of the Asset Purchase Agreement (i.e. January 19, 2013), the holders of Series C-1² Stock may redeem a number of shares of Series C-1² Stock equal to the lesser of (i) the entire balance of the outstanding Series C-1² Stock, or (ii) 2,900 shares of Series C-1² Stock. The 2012 New Preferred Stock also allows for redemption by its holders following the occurrence of certain other events. If the holders of Series C-1 ² Stock redeem a number of shares of Series C-1 ² Stock equal to or greater than the lesser of (i) the entire balance of the outstanding Series C-1 ² Stock or (ii) 2,900 shares of Series C-1 ² Stock, then Solana shall have the right for a period of 10 business days following the earlier of (i) or (ii) above, to elect to purchase from the Company all right, title and interest in and to the Purchased Assets, including any assets and patent rights arising from the Purchased Assets after the Closing of the asset purchase, upon repaying to the Company the nominal consideration paid pursuant to the Agreement.

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Preferred Stock (Details) (USD $)	9 Months Ended
	Sep. 30, 2012	Dec. 31, 2011
Preferred Stock (Textual) [Abstract]
Authorized preferred stock	8,000,000
Par value of preferred stock	0.0001
Series C-1 Preferred Stock [Member]
Preferred Stock (Textual) [Abstract]
Authorized preferred stock	11,000
Shares converted to common stock	31
Preferred Stock Issued	5,386	5,043
Preferred stock outstanding		5,043
Series D-1 Warrants [Member]
Preferred Stock (Textual) [Abstract]
Warrants converted to preferred stock	4,021
Series C-2 Preferred Stock [Member]
Preferred Stock (Textual) [Abstract]
Authorized preferred stock	22,000
Series D-1 Preferred Stock [Member]
Preferred Stock (Textual) [Abstract]
Authorized preferred stock	5,134
Preferred stock, shares issued upon conversion of warrants	3,611
Shares converted to common stock	16
Preferred stock outstanding	3,595
Series D-2 Preferred Stock [Member]
Preferred Stock (Textual) [Abstract]
Authorized preferred stock	10,868

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Net Income (Loss) per Share (Tables)

9 Months Ended

Sep. 30, 2012

Net Income (Loss) per Share [Abstract]

Computation of basic and diluted EPS

	Three Months Ended September 30,						Nine Months Ended September 30,
	2012			2011			2012			2011
Numerator
Net income (loss)	$	(2,222	)	$	3,570		$	(4,632	)	$	1,775
Preferred stock dividends forfeited (earned)		(205	)		(3	)		(281	)		75
Numerator for basic EPS – net income (loss) attributable to common stockholders		(2,427	)		3,567			(4,913	)		1,850
Effect of dilutive securities:
Preferred stock dividends		—			—			—			—
Numerator for diluted EPS – net income (loss) attributable to common stockholders	$	(2,427	)	$	3,567		$	(4,913	)	$	1,850
Denominator:
Weighted-average shares outstanding
Basic EPS		13,253			533			8,995			224
Effect of dilutive convertible preferred stock and warrants		—			12,347			—			48,472
Denominator for diluted EPS		13,253			12,880			8,995			48,696
Basic EPS	$	(0.18	)	$	6.69		$	(0.55	)	$	8.25
Diluted EPS	$	(0.18	)	$	0.28		$	(0.55	)	$	0.04

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Stockholders' Equity (Details) (USD $)	9 Months Ended
	Sep. 30, 2012
Summary of stock option activity and related data
Balance at December 31, 2011, Number of Shares	894
Balance at December 31, 2011, Weighted-Average Exercise Price	$ 17,462
Options Granted, Number	592,230,471
Options Granted, Weighted-Average Exercise Price	$ 0.06
Options Outstanding, Number, Forfeited/Expired in Period	(795)
Options Forfeited/Expired, Weighted-Average Exercise Price	$ 11,420
Balance at September 30, 2012, Number of Shares	592,230,570
Balance at September 30, 2012, Weighted-Average Exercise Price	$ 0.067

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Accounting Policies (Details) (USD $)	1 Months Ended	3 Months Ended	9 Months Ended
	May 31, 2010	Jun. 30, 2011	Sep. 30, 2012	Sep. 30, 2011	Mar. 03, 2012	Dec. 31, 2011	May 07, 2011
Accounting Policies (Textual) [Abstract]
Common Stock authorized for issuance			12,008,000,000			6,008,000,000
Non-cash charge to general and administrative expense as an impairment		$ 243,000
Reverse Stock Split effective date			February 17, 2012	April 14, 2011
Reverse Stock Split exchange ratio			1-for-100
Conversion of Preferred Stock into Common Stock			613		213,083		166,667
Convertible preferred stock for initial proceeds	$ 6,003,000

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Accounting Policies

9 Months Ended

Sep. 30, 2012

Accounting Policies [Abstract]

Accounting Policies

2. Accounting Policies

Corporate Structure

The Company was originally incorporated in Delaware in 1989. At the annual meeting of stockholders of the Delaware company on May 22, 2012, the stockholders, upon the recommendation of the Delaware company’s board of directors, approved a proposal to merge the Delaware company with and into its wholly-owned subsidiary, LJPC Merger Sub, Inc., for the purpose of changing the domicile of the Company from Delaware to California (the “Merger”). Following stockholder approval, the Merger was effected on June 7, 2012. As a result, the Company is now a California corporation and LJPC Merger Sub, Inc. changed its name to La Jolla Pharmaceutical Company. The authorized capital stock of the Company increased from 6,008,000,000 to 12,008,000,000 shares. All common and preferred shares of the Delaware company were exchanged for common and preferred shares of the Company.

Use of Estimates

The preparation of condensed financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the unaudited condensed financial statements and disclosures made in the accompanying notes to the unaudited condensed financial statements. These include the assumptions discussed below relating to the calculation of our derivative liabilities. Actual results could differ materially from those estimates.

Recent Accounting Pronouncements

Effective January 1, 2012, the Company adopted the guidance issued by the FASB in May 2011, regarding common fair value measurements and disclosure requirements in U.S. GAAP and IFRS. This accounting standard clarifies the application of certain existing fair value measurement guidance and expands the disclosures for fair value measurements that are estimated using significant unobservable inputs. The adoption of this standard did not have a material impact on the financial position or results of operations of the Company.

Effective January 1, 2012, the Company adopted the guidance issued by the FASB in June 2011 and amended in December 2011, regarding comprehensive income. This accounting standard (1) eliminates the option to present the components of other comprehensive income as part of the statement of changes in stockholders’ equity; and (2) requires the consecutive presentation of the statement of net income and other comprehensive income. The amendments do not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income nor do the amendments affect how earnings per share is calculated or presented. As this accounting standard only requires enhanced disclosure, the adoption of this standard did not impact the Company’s financial position or results of operations.

Impairment of Long-Lived Assets

If indicators of impairment exist, the Company assesses the recoverability of the affected long-lived assets by determining whether the carrying value of such assets can be recovered through the undiscounted future operating cash flows.

As a result of the negative results in the confirmatory preclinical study of LJP1485 in May 2011, the Company discontinued the development of LJP1485 in May 2011 and in June 2011 the Company sold the Compounds back to GliaMed for the same nominal amount that it had paid for them. Based on these events, the future cash flows from the patents related to the Compounds were no longer expected to exceed their carrying values and the assets became impaired as of May 31, 2011. Accordingly, during the quarter ended June 30, 2011, the Company recorded a non-cash charge of $243,000 to general and administrative expense for the impairment of long-lived assets to write down the value of the Company’s patents to their estimated fair values.

Reverse Stock Split

The Board of Directors approved the reverse stock split (the “2012 Reverse Stock Split”) of the Company’s common stock, which became effective on February 17, 2012, with an exchange ratio of 1-for-100. As a result of the 2012 Reverse Stock Split, each 100 shares of the Company’s issued and outstanding common stock were automatically reclassified as and changed into one share of the Company’s common stock. No fractional shares were issued in connection with the 2012 Reverse Stock Split. Stockholders who were entitled to fractional shares instead became entitled to receive a cash payment in lieu of receiving fractional shares (after taking into account and aggregating all shares of the Company’s common stock then held by such stockholder) equal to the fractional share interest. The 2012 Reverse Stock Split affected all of the holders of the Company’s common stock uniformly. Effective on March 3, 2012, each share of 2012 New Preferred Stock was convertible into approximately 213,083 shares of common stock.

The Board of Directors approved the reverse stock split (the “2011 Reverse Stock Split”) of the Company’s common stock, which became effective on April 14, 2011, with an exchange ratio of 1-for-100. As a result of the 2011 Reverse Stock Split, each 100 shares of the Company’s issued and outstanding common stock were automatically reclassified as and changed into one share of the Company’s common stock. No fractional shares were issued in connection with the 2011 Reverse Stock Split. Stockholders who were entitled to fractional shares instead became entitled to receive a cash payment in lieu of receiving fractional shares (after taking into account and aggregating all shares of the Company’s common stock then held by such stockholder) equal to the fractional share interest. The 2011 Reverse Stock Split affected all of the holders of the Company’s common stock uniformly. Effective on May 7, 2011, each share of New Preferred Stock was convertible into approximately 166,667 shares of common stock.

All common stock share and per share information in the accompanying unaudited condensed financial statements have been restated to reflect retrospective application of the 2012 and 2011 Reverse Stock Split for all periods presented, except for par value per share and the number of authorized shares, which were not affected. Shares of the Company’s common stock underlying outstanding options and warrants were proportionately reduced and the exercise prices of outstanding options and warrants were proportionately increased in accordance with the terms of the agreements governing such securities. Shares of the Company’s common stock underlying outstanding convertible preferred stock and warrants were proportionately reduced and the conversion rates were proportionately decreased in accordance with the terms of the agreements governing such securities.

Net Income (Loss) Per Share

Basic and diluted net income (loss) per share is computed using the weighted-average number of common shares outstanding during the periods. Basic earnings per share (“EPS”) is calculated by dividing the net income or loss by the weighted-average number of common shares outstanding for the period, without consideration for common stock equivalents. Diluted EPS is computed by dividing the net income or loss by the weighted-average number of common shares and common stock equivalents outstanding for the period issuable upon the conversion of preferred stock and exercise of stock options and warrants. These common stock equivalents are included in the calculation of diluted EPS only if their effect is dilutive (see Note 11). There is no difference between basic and diluted net loss per share for the three and nine months ended September 30, 2012, as potentially dilutive securities have been excluded from the calculation of diluted net loss per common share because the inclusion of such securities would be antidilutive.

Derivative Liabilities

In May 2010, the Company entered into definitive agreements with institutional investors and affiliates for a private placement of common stock, redeemable convertible preferred stock and warrants to purchase convertible preferred stock for initial proceeds of $6,003,000 (the “May 2010 Financing”). In conjunction with the May 2010 Financing, the Company issued redeemable convertible preferred stock that contained certain embedded derivative features, as well as warrants that are accounted for as derivative liabilities (see Note 6). These derivative liabilities were determined to be ineligible for equity classification due to certain provisions of the underlying preferred stock, which is also ineligible for equity classification, whereby redemption is outside the sole control of the Company due to provisions that may result in an adjustment to their exercise or conversion price.

The Company’s derivative liabilities were initially recorded at their estimated fair value on the date of issuance and are subsequently adjusted to reflect the estimated fair value at each period end, with any decrease or increase in the estimated fair value being recorded as other income or expense, accordingly. The fair value of these liabilities is estimated using option pricing models that are based on the individual characteristics of the common stock and preferred stock, the derivative liability on the valuation date, probabilities related to the Company’s operations and clinical development (based on industry data), as well as assumptions for volatility, remaining expected life, risk-free interest rate and, in some cases, credit spread. The option pricing models are particularly sensitive to changes in the aforementioned probabilities and the closing price per share of the Company’s common stock.

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Condensed Balance Sheets (Parenthetical) (USD $) In Thousands, except Share data, unless otherwise specified	Sep. 30, 2012	Dec. 31, 2011
Condensed Balance Sheets [Abstract]
Preferred stock, par value	$ 0.0001	$ 0.0001
Preferred stock, shares authorized	11,000	11,000
Preferred stock, shares issued	5,386	5,043
Preferred stock, shares outstanding	5,386	5,043
Redemption value	$ 5,667	$ 5,116
Preferred stock, liquidation preference value	$ 5,667	$ 5,116

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Commitments and Contingencies

9 Months Ended

Sep. 30, 2012

Commitments and Contingencies [Abstract]

Commitments and Contingencies

12. Commitments and Contingencies

As of September 30, 2012, there were no material operating leases, notes payable, purchase commitments or capital leases.

The Company maintains its operations in a temporary space under a short-term arrangement.

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Document and Entity Information	9 Months Ended
	Sep. 30, 2012	Nov. 02, 2012
Document and Entity Information [Abstract]
Entity Registrant Name	LA JOLLA PHARMACEUTICAL CO
Entity Central Index Key	0000920465
Document Type	10-Q
Document Period End Date	Sep. 30, 2012
Amendment Flag	false
Document Fiscal Year Focus	2012
Document Fiscal Period Focus	Q3
Current Fiscal Year End Date	--12-31
Entity Filer Category	Smaller Reporting Company
Entity Common Stock, Shares Outstanding		13,567,383

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Accounting Policies (Policies)

9 Months Ended

Sep. 30, 2012

Accounting Policies [Abstract]

Corporate Structure

Corporate Structure

The Company was originally incorporated in Delaware in 1989. At the annual meeting of stockholders of the Delaware company on May 22, 2012, the stockholders, upon the recommendation of the Delaware company’s board of directors, approved a proposal to merge the Delaware company with and into its wholly-owned subsidiary, LJPC Merger Sub, Inc., for the purpose of changing the domicile of the Company from Delaware to California (the “Merger”). Following stockholder approval, the Merger was effected on June 7, 2012. As a result, the Company is now a California corporation and LJPC Merger Sub, Inc. changed its name to La Jolla Pharmaceutical Company. The authorized capital stock of the Company increased from 6,008,000,000 to 12,008,000,000 shares. All common and preferred shares of the Delaware company were exchanged for common and preferred shares of the Company.

Use of Estimates

Use of Estimates

The preparation of condensed financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the unaudited condensed financial statements and disclosures made in the accompanying notes to the unaudited condensed financial statements. These include the assumptions discussed below relating to the calculation of our derivative liabilities. Actual results could differ materially from those estimates.

Recent Accounting Pronouncements

Recent Accounting Pronouncements

Effective January 1, 2012, the Company adopted the guidance issued by the FASB in May 2011, regarding common fair value measurements and disclosure requirements in U.S. GAAP and IFRS. This accounting standard clarifies the application of certain existing fair value measurement guidance and expands the disclosures for fair value measurements that are estimated using significant unobservable inputs. The adoption of this standard did not have a material impact on the financial position or results of operations of the Company.

Effective January 1, 2012, the Company adopted the guidance issued by the FASB in June 2011 and amended in December 2011, regarding comprehensive income. This accounting standard (1) eliminates the option to present the components of other comprehensive income as part of the statement of changes in stockholders’ equity; and (2) requires the consecutive presentation of the statement of net income and other comprehensive income. The amendments do not change the items that must be reported in other comprehensive income or when an item of other comprehensive income must be reclassified to net income nor do the amendments affect how earnings per share is calculated or presented. As this accounting standard only requires enhanced disclosure, the adoption of this standard did not impact the Company’s financial position or results of operations.

Impairment of Long-Lived Assets

Impairment of Long-Lived Assets

If indicators of impairment exist, the Company assesses the recoverability of the affected long-lived assets by determining whether the carrying value of such assets can be recovered through the undiscounted future operating cash flows.

As a result of the negative results in the confirmatory preclinical study of LJP1485 in May 2011, the Company discontinued the development of LJP1485 in May 2011 and in June 2011 the Company sold the Compounds back to GliaMed for the same nominal amount that it had paid for them. Based on these events, the future cash flows from the patents related to the Compounds were no longer expected to exceed their carrying values and the assets became impaired as of May 31, 2011. Accordingly, during the quarter ended June 30, 2011, the Company recorded a non-cash charge of $243,000 to general and administrative expense for the impairment of long-lived assets to write down the value of the Company’s patents to their estimated fair values.

Reverse Stock Split

Reverse Stock Split

The Board of Directors approved the reverse stock split (the “2012 Reverse Stock Split”) of the Company’s common stock, which became effective on February 17, 2012, with an exchange ratio of 1-for-100. As a result of the 2012 Reverse Stock Split, each 100 shares of the Company’s issued and outstanding common stock were automatically reclassified as and changed into one share of the Company’s common stock. No fractional shares were issued in connection with the 2012 Reverse Stock Split. Stockholders who were entitled to fractional shares instead became entitled to receive a cash payment in lieu of receiving fractional shares (after taking into account and aggregating all shares of the Company’s common stock then held by such stockholder) equal to the fractional share interest. The 2012 Reverse Stock Split affected all of the holders of the Company’s common stock uniformly. Effective on March 3, 2012, each share of 2012 New Preferred Stock was convertible into approximately 213,083 shares of common stock.

The Board of Directors approved the reverse stock split (the “2011 Reverse Stock Split”) of the Company’s common stock, which became effective on April 14, 2011, with an exchange ratio of 1-for-100. As a result of the 2011 Reverse Stock Split, each 100 shares of the Company’s issued and outstanding common stock were automatically reclassified as and changed into one share of the Company’s common stock. No fractional shares were issued in connection with the 2011 Reverse Stock Split. Stockholders who were entitled to fractional shares instead became entitled to receive a cash payment in lieu of receiving fractional shares (after taking into account and aggregating all shares of the Company’s common stock then held by such stockholder) equal to the fractional share interest. The 2011 Reverse Stock Split affected all of the holders of the Company’s common stock uniformly. Effective on May 7, 2011, each share of New Preferred Stock was convertible into approximately 166,667 shares of common stock.

All common stock share and per share information in the accompanying unaudited condensed financial statements have been restated to reflect retrospective application of the 2012 and 2011 Reverse Stock Split for all periods presented, except for par value per share and the number of authorized shares, which were not affected. Shares of the Company’s common stock underlying outstanding options and warrants were proportionately reduced and the exercise prices of outstanding options and warrants were proportionately increased in accordance with the terms of the agreements governing such securities. Shares of the Company’s common stock underlying outstanding convertible preferred stock and warrants were proportionately reduced and the conversion rates were proportionately decreased in accordance with the terms of the agreements governing such securities.

Net Income (Loss) Per Share

Net Income (Loss) Per Share

Basic and diluted net income (loss) per share is computed using the weighted-average number of common shares outstanding during the periods. Basic earnings per share (“EPS”) is calculated by dividing the net income or loss by the weighted-average number of common shares outstanding for the period, without consideration for common stock equivalents. Diluted EPS is computed by dividing the net income or loss by the weighted-average number of common shares and common stock equivalents outstanding for the period issuable upon the conversion of preferred stock and exercise of stock options and warrants. These common stock equivalents are included in the calculation of diluted EPS only if their effect is dilutive (see Note 11). There is no difference between basic and diluted net loss per share for the three and nine months ended September 30, 2012, as potentially dilutive securities have been excluded from the calculation of diluted net loss per common share because the inclusion of such securities would be antidilutive.

Derivative Liabilities

Derivative Liabilities

In May 2010, the Company entered into definitive agreements with institutional investors and affiliates for a private placement of common stock, redeemable convertible preferred stock and warrants to purchase convertible preferred stock for initial proceeds of $6,003,000 (the “May 2010 Financing”). In conjunction with the May 2010 Financing, the Company issued redeemable convertible preferred stock that contained certain embedded derivative features, as well as warrants that are accounted for as derivative liabilities (see Note 6). These derivative liabilities were determined to be ineligible for equity classification due to certain provisions of the underlying preferred stock, which is also ineligible for equity classification, whereby redemption is outside the sole control of the Company due to provisions that may result in an adjustment to their exercise or conversion price.

The Company’s derivative liabilities were initially recorded at their estimated fair value on the date of issuance and are subsequently adjusted to reflect the estimated fair value at each period end, with any decrease or increase in the estimated fair value being recorded as other income or expense, accordingly. The fair value of these liabilities is estimated using option pricing models that are based on the individual characteristics of the common stock and preferred stock, the derivative liability on the valuation date, probabilities related to the Company’s operations and clinical development (based on industry data), as well as assumptions for volatility, remaining expected life, risk-free interest rate and, in some cases, credit spread. The option pricing models are particularly sensitive to changes in the aforementioned probabilities and the closing price per share of the Company’s common stock.

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Condensed Statements of Comprehensive Income (Loss) (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Expenses:
Research and development	$ 474		$ 844	$ 177
General and administrative	2,974	423	6,485	1,628
Total expenses	3,448	423	7,329	1,805
Loss from operations	(3,448)	(423)	(7,329)	(1,805)
Other income (expense):
Adjustments to fair value of derivative liabilities	1,227	3,993	2,696	3,346
Other income (expense), net	(1)		1	234
Net income (loss)	(2,222)	3,570	(4,632)	1,775
Preferred stock dividend forfeited (earned)	(205)	(3)	(281)	75
Net income (loss) and comprehensive income (loss) attributable to common stockholders	$ (2,427)	$ 3,567	$ (4,913)	$ 1,850
Net income (loss) per basic share	$ (0.18)	$ 6.69	$ (0.55)	$ 8.25
Net income (loss) per diluted share	$ (0.18)	$ 0.28	$ (0.55)	$ 0.04
Shares used in computing basic net income (loss) per share	13,253	533	8,995	224
Shares used in computing diluted net income (loss) per share	13,253	12,880	8,995	48,696

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Preferred Stock

9 Months Ended

Sep. 30, 2012

Preferred Stock [Abstract]

Preferred Stock

7. Preferred Stock

Preferred Stock

As of September 30, 2012, the Company’s Board of Directors is authorized to issue 8,000,000 shares of preferred stock, with a par value of $0.0001 per share, in one or more series, of which 11,000 are designated for Series C-1² Preferred, 22,000 are designated Series C-2² Preferred, 5,134 are designated Series D-1² Preferred, and 10,868 are designated Series D-2² Preferred. During the nine months ended September 30, 2012, 4,021 Series D-1² Warrants were converted into Series D-1² Preferred, by means of a cashless exercise, resulting in the issuance of 3,611 shares of Series D-1² Preferred. Also during the nine months ended September 30, 2012, there have been 16 shares of Series D-1 ² Preferred and 31 shares of Series C-1 ² Preferred converted to common stock. As of September 30, 2012, 5,386 shares of Series C-1 ² Preferred Stock and 3,595 shares of Series D-1 ² were issued and outstanding. As of December 31, 2011, 5,043 shares of Series C-1² Preferred Stock were issued and outstanding.

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Securities Purchase Agreement

9 Months Ended

Sep. 30, 2012

Securities Purchase Agreement [Abstract]

Securities Purchase Agreement

6. Securities Purchase Agreement

On May 24, 2010, the Company entered into a Securities Purchase Agreement by and among the Company and the purchasers named therein (the “Purchasers”). The Purchasers included institutional investors as well as the Company’s then Chief Executive Officer and Chief Financial Officer as well as an additional Company employee at that time. The total investment by these Company employees represented less than 3% of the proceeds received by the Company in the May 2010 Financing. Pursuant to the Securities Purchase Agreement, on May 26, 2010 (the “Closing Date” or “Closing”), for total consideration of $6,003,000, the Purchasers purchased (i) an aggregate of 2,897 shares of the Company’s Common Stock, par value $0.0001 per share, at a contractually stated price of $300 per share, and (ii) 5,134 shares of the Company’s Series C-1 Preferred, par value $0.0001 per share, at a contractually stated price of $1,000 per share. The Purchasers also received (i) Series D-1 Warrants to purchase 5,134 shares of the Company’s Series D-1 Preferred, par value $0.0001 per share, at an exercise price of $1,000 per share, which warrants may be exercised on a cashless basis, and (ii) Series C-2 Warrants to purchase 10,268 units, at an exercise price of $1,000 per unit, which warrants are exercisable only in cash, with each unit consisting of one share of the Company’s Series C-2 Preferred, par value $0.0001 per share, and an additional Series D-2 Warrant to purchase one share of the Company’s Series D-2 Preferred, par value $0.0001 per share, at an exercise price of $1,000 per share.

At the Closing Date, the estimated fair value of the Series C-2 Warrants for units, Series D-1 Warrants, and the embedded derivatives included within the Series C-1 Preferred exceeded the proceeds from the May 2010 Financing of $6,003,000 (see the valuations of these derivative liabilities under the heading, “Derivative Liabilities” below). As a result, all of the proceeds were allocated to these derivative liabilities and no proceeds remained for allocation to the Common Stock and Series C-1 Preferred issued in the financing.

In March 2011, the Company entered into the Consent Agreement that amended the terms of the Securities Purchase Agreement. Under the Consent Agreement, the holders agreed to the following, among other changes: (i) a temporary suspension of dividends on Series C-1 ¹ Preferred and Series C-2 ¹ Preferred (ii) to provide an additional cash payment of approximately $236,000 in exchange for the right to receive Series C-2¹ Preferred upon the achievement of certain pre-specified results in the preclinical study of one of the Compounds (the “Preclinical Milestone”), (iii) to increase the warrants that must be exercised for cash from 10,268 to 10,646 units, (iv) the mandatory exercise of $7,452,000 of such warrants upon the achievement of the Preclinical Milestone, (v) the mandatory exercise of the remaining $3,194,000 of warrants upon the achievement of a future clinical milestone and (vi) an automatic one-time downward conversion price adjustment following the 2011 Reverse Stock Split.

The Company filed its Series C/D Certificate and Series E Certificate (collectively, the “Certificates”) with the State of Delaware on March 30, 2011. Each Certificate provided the holders with the following rights (the Series C/D Certificate was superseded by the Series C-1²/D-1 ² Certificate that was filed on January 20, 2012 and the Series C-1²/D-1 ² Certificate was superseded by the Articles of Incorporation of LJPC California filed in connection with the Company’s reincorporation from Delaware to California):

• The holders of New Preferred Stock and Series E Preferred Stock (collectively, the “C/D/E Preferred Stock”) did not have voting rights unless required by the Delaware General Corporation Law or as set forth below.

• Cumulative dividends were payable on the Series C-1 ¹ Stock and Series C-2 ¹ Stock (together referred to herein as the “Series C ¹ Preferred”) at a rate of 15% per annum and on the Series E Preferred Stock at a rate of 5% per annum, each accruing from the date of issuance through the date of conversion or redemption, payable semi-annually in shares of Series C-1 ¹ Stock, Series C-2 ¹ Stock and Series E Preferred Stock, respectively, but subject to the temporary suspension of dividends with respect to the Series C¹ Preferred, as described above. Neither the Series D-1¹ Stock nor the Series D-2 ¹ Stock was entitled to dividends.

• The C/D/E Preferred Stock was convertible into common stock, initially at a rate of 66,667 shares of common stock for each share of C/D/E Preferred Stock, subject to certain limitations discussed below, at the election of the holders of C/D/E Preferred Stock. The conversion rate was adjusted for certain events, such as stock splits, stock dividends, reclassifications and recapitalizations, and the New Preferred Stock was subject to full-ratchet anti-dilution protection such that any subsequent issuance of common stock below the effective conversion price of the C/D/E Preferred Stock at the time of such issuance automatically adjusts the conversion price of the C/D/E Preferred Stock to such lower price. There were also limits on the amount of C/D/E Preferred Stock that could be converted and the timing of such conversions. The New Preferred Stock could be converted starting the first Monday following the Closing of the asset purchase. The Series E Preferred Stock could not be converted until the first Monday following the achievement of the Preclinical Milestone under the Agreement.

• Upon a Liquidation Event (as defined in each Certificate), no other class or series of capital stock could receive any payment unless the New Preferred Stock has first received a payment in an amount equal to $1,000 per share, plus all accrued and unpaid dividends, if applicable. Once the New Preferred Stock received its liquidation payment, the Series E Preferred Stock was entitled to receive a payment in an amount equal to $1,000 per share, plus all accrued and unpaid dividends, if applicable.

• In the event that certain actions occurred without the prior written consent of the holders of two-thirds of the then outstanding shares of New Preferred Stock (the “Requisite Holders”), such as the Company’s material breach of any material representation or warranty under the Securities Agreement, a suspension of the trading of the Company’s common stock, the failure to timely deliver shares on conversion of the C/D/E Preferred Stock, or the consummation of a Change of Control (as defined in the Certificate of Designations), then the holders of the Series C ¹ Preferred had the right, upon the delivery of a notice to the Company by the Requisite Holders, to have such shares redeemed by the Company for an amount equal to the greater of $1,000 per share, plus accrued and unpaid dividends, or the fair market value of the underlying common stock issuable upon conversion of the Series C ¹ Preferred. The Series E Preferred Stock did not have similar redemption rights.

• Upon certain redemption events, such as the Company’s breach of covenants or material representations or warranties under the Purchase Agreement, the conversion price of the C/D/E Preferred Stock would decrease to 10% of the conversion price in effect immediately before such redemption event.

• So long as at least 1,000 shares of New Preferred Stock remained outstanding (or at least 3,000 shares of New Preferred Stock remained outstanding if the Cash Warrants had been fully exercised), the Company may not take a variety of actions (such as altering the rights, powers, preferences or privileges of the New Preferred Stock so as to effect the New Preferred Stock adversely, amending any provision of the Company’s certificate of incorporation, entering into an agreement for a Strategic Transaction or Change of Control (as each is defined in the Series C/D Certificate, and may not consummate any financing or file a registration statement with the Securities and Exchange Commission without the prior approval of the Requisite Holders. The Series E Preferred Stock did not have similar protective provisions.

In June 2011, the Company entered into the Amendment Agreement that amended the terms of the Securities Purchase Agreement and the Consent Agreement. Under the Amendment Agreement, the Holders agreed to the following, among other changes: (i) a temporary waiver of dividends on Series C-1 ¹ Preferred (ii) to provide additional working capital by July 29, 2011, in an amount to be determined, if the Requisite Holders (as defined in the Amendment Agreement) determined by July 22, 2011 that, as of such date, the Company was continuing to pursue a Strategic Transaction (as defined in the Amendment Agreement) (iii) to purchase up to all of the outstanding Series C-1¹ Preferred and certain warrants held by then current and former Company employees, including the executive officers at that time, who will have the right to require the Holder to purchase these securities for a limited period of time following the employee’s termination of service with the Company.

In August 2011, the Company entered into a Second Amendment Agreement that extended the terms of the Amendment Agreement through October 31, 2011. Under the Second Amendment Agreement, the Holders agreed to the following, among other changes: (i) to continue a temporary waiver of dividends on Series C-1¹ Preferred (ii) to provide additional working capital, in an amount to be determined, if the Requisite Holders (as defined in the Second Amendment Agreement) determine by September 2, 2011, and then again by September 26, 2011, that, as of such date, the Company was continuing to pursue a Strategic Transaction (as defined in the Second Amendment Agreement) (iii) to purchase up to all of the outstanding Series C-1 ¹ Preferred and certain warrants held by then current and former Company employees, including the executive officers at that time, who will have the right to require the Holder to purchase these securities for a limited period of time following the employee’s termination of service with the Company.

Accounting Treatment

On May 26, 2010, the Company issued 5,134 shares of Series C-1² Preferred and recorded the par value of $0.0001 per share with a corresponding reduction to paid-in capital, given that there was no allocated value from the proceeds to the Series C-1 ² Preferred.

Under accounting guidance covering accounting for redeemable equity instruments, preferred securities that are redeemable for cash or other assets are to be classified outside of permanent equity (within the mezzanine section between liabilities and equity on the balance sheets) if they are redeemable at the option of the holder or upon the occurrence of an event that is not solely within the control of the issuer. As there are redemption-triggering events related to the Series C-1² Preferred that are not solely within the control of the Company, the Series C-1² Preferred was classified outside of permanent equity.

The Company may be required to redeem the Series C-1² Preferred if a redemption event occurs. Since the Company did not consummate a Strategic Transaction by February 26, 2011, the Series C-1 ² Preferred is currently redeemable and therefore the Company adjusted the carrying value of the Series C-1 ² Preferred to the redemption value of such shares. The carrying value at September 30, 2012, of $5,800,000 represents the redemption value of the Series C-1² Preferred plus accrued and unpaid dividends.

Derivative Liabilities

The Series C-1 ² Preferred and the underlying securities of the Series C-2² Warrants for units and Series D-1² Warrants contain conversion features. In addition, the Series C-1² Preferred and the underlying securities of the Series C-2² Warrants for units are subject to redemption provisions that are outside of the control of the Company.

The Series C-2² Warrants and Series D-1 ² Warrants are exercisable starting on the issuance date and expire three years from the date of issuance. The Series C-2² Warrants must be exercised in cash and, beginning in June 2011, they are no longer subject to mandatory exercise terms. The Series D-1² Warrants may be exercised on a cashless basis and are not subject to mandatory exercise terms.

Accounting Treatment

The Company accounts for the conversion and redemption features embedded in the Series C-1 ² Preferred (the “Embedded Derivatives”) in accordance with accounting guidance covering derivatives. Under this accounting guidance, companies may be required to bifurcate conversion and redemption features embedded in redeemable convertible preferred stock from their host instruments and account for these embedded derivatives as free standing derivative financial instruments. If the underlying security of the embedded derivative requires net cash settlement in the event of circumstances that are not solely within the Company’s control, the embedded derivative should be classified as a liability, measured at fair value at issuance and adjusted to their current fair value at each period. As there are redemption triggering events for net cash settlement for Series C-1 ² Preferred that are not solely within the Company’s control, and the conversion feature is a derivative, the Embedded Derivatives are classified as liabilities and are accounted for using fair value accounting at each reporting date (also see Note 3).

The Company accounts for the Series C-2² Warrants for units and Series D-1² Warrants in accordance with accounting guidance covering derivatives. If the underlying security of the warrant, a.) requires net cash settlement in the event of circumstances that are not solely within the Company’s control or if not, if they are b.) not indexed to the Company’s own stock, the warrants should be classified as liabilities, measured at fair value at issuance and adjusted to their current fair value at each period. As there are redemption triggering events for Series C-2² Preferred that are not solely within the Company’s control, and the Series D-1² Preferred are not indexed to the Company’s own stock, the Series C-2² Warrants for units and Series D-1² Warrants are classified as liabilities and are accounted for using fair value accounting at each reporting date. The Embedded Derivatives, Series C-2² Warrants for units and Series D-1² Warrants are collectively referred to as the “Derivative Liabilities”.

The estimated fair values of the Derivative Liabilities as of September 30, 2012 and December 31, 2011 are summarized as follows (in thousands):

	Fair Value Measurement at
	September 30, 2012		December 31, 2011
Embedded Derivatives of Series C-1 2 Preferred (including dividends paid in Series C-1 2 Preferred)	$	3,707	$	3,628
Embedded Derivatives of accrued dividends payable in Series C-1 2 Preferred		193		52
Series D-1 2 Warrants		571		2,539
Series C-2 2 Warrants for:
Series C-2 2 Preferred		2,782		3,785
Series D-2 2 Warrants		5,464		5,266
	$	12,717	$	15,270

The Derivative Liabilities were valued using binomial option pricing models with various assumptions detailed below. Due to the six month trading restriction on the unregistered shares of common stock issued or issuable from the conversion of Preferred Stock and the weekly conversion limitation on Preferred Stock as well as the uncertainty of the Company’s ability to continue as a going concern, the price per share of the Company’s common stock used in the binomial option pricing models for the Derivative Liabilities was discounted from the closing market prices of $0.06 and $0.27 on September 30, 2012 and December 31, 2011, respectively. The expected lives that were used to value each of the Derivative Liabilities were based on the individual characteristics of the underlying Preferred Stock, which impact the expected timing of conversion into common stock. In addition, the probabilities associated with the successful clinical development of a drug candidate based on industry data were used in each of the binomial option pricing models. The models used to value the Series C-2² Warrants and Series D-1² Warrants are particularly sensitive to such probabilities, as well as to the closing price per share of the Company’s common stock. To better estimate the fair value of the Derivative Liabilities at each reporting period, the binomial option pricing models and their inputs were refined based on information available to the Company. Such changes did not have a significant impact on amounts recorded in previous interim reporting periods.

At December 31, 2011, the total value of the Embedded Derivatives was $3,680,000. At September 30, 2012, the total value of the Embedded Derivatives was $3,900,000, resulting in non-cash other expense on the increase in the estimated fair value of the Embedded Derivatives for the nine months ended September 30, 2012 of $77,000 (exclusive of the net increase in the liability of $143,000 due to the accrual of dividends). Such increase in value was primarily due to the changes in the Company’s common stock price and adjustment to the conversion price of the preferred stock, after consideration of the 2012 Reverse Stock Split and the updates to the assumptions used in the option pricing models.

The Embedded Derivatives were valued at September 30, 2012 and December 31, 2011 using a binomial option pricing model, based on the value of the Series C-1 ² Preferred shares with and without embedded derivative features, with the following assumptions:

	September 30, 2012			December 31, 2011
Closing price per share of common stock	$	0.044		$	0.27
Conversion price per share	$	0.005		$	0.60
Volatility		98.2	%		88.0	%
Risk-free interest rate		0.58	%		0.83	%
Credit spread		19.8	%		20.9	%
Remaining expected lives of underlying securities (years)		4.8			5.0

On December 31, 2011, the Series D-1 ² Warrants were recorded at estimated fair value of $2,539,000. On September 30, 2012, the Series D-1² Warrants were revalued at $571,000 resulting in non-cash other income on the decrease in the estimated fair value of the Series D-1² Warrants of $1,968,000. Such decrease in value was primarily due to the exercise of 3,611 Series D-1² Warrants and updates to the assumptions used in the option pricing models.

The Series D-1² Warrants were valued at September 30, 2012 and December 31, 2011 using a binomial option pricing model with the following assumptions:

	September 30, 2012			December 31, 2011
Closing price per share of common stock	$	0.044		$	0.27
Conversion price per share	$	0.005		$	0.60
Volatility		74.8	%		67.5	%
Risk-free interest rate		0.23	%		0.28	%
Remaining expected lives of underlying securities (years)		2.5			2.2
Probability of Strategic Transaction		41	%		70	%

On December 31, 2011, the Series C-2 ² Warrants (which consist of rights to purchase Series C-2 ² Preferred and Series D-2 ² Warrants) were recorded at an estimated fair value of $9,051,000. On September 30, 2012, the Series C-2² Warrants were revalued at $8,246,000, resulting in non-cash other income on the decrease in the estimated fair value of the Series C-2 ² Warrants of $805,000. Such decrease in value was primarily due to the extension of the term to cover the longer clinical trial period, and the updates to the assumptions used in the option pricing models.

The portion of the Series C-2 ² Warrants that represent the rights to purchase Series C-2 ² Preferred were valued at September 30, 2012 and December 31, 2011 using a binomial option pricing model. The pricing model determines the value of the Series C-2² Preferred at the warrant exercise date, which is assumed to be at the end of the successful Phase 2 clinical trial and subtracts the value of the Series C-2 ² Preferred with the exercise price. The assumptions are:

	September 30, 2012			December 31, 2011
Closing price per share of common stock	$	0.044		$	0.27
Conversion price per share	$	0.005		$	0.60
Volatility		98.2	%		88.0	%
Risk-free interest rate		0.58	%		0.83	%
Credit spread		19.8	%		20.9	%
Remaining expected lives of underlying securities (years)		4.8			5.0
Time to exercise (months)		21			24

The Series D-2 ² Warrants were valued at September 30, 2012 and December 31, 2011 using a binomial option pricing model with the same assumptions used in the valuation of the Series D-1² Warrants. The increase in the value of the Series D-2² Warrants for the nine months ended September 30, 2012 of $198,000 was primarily due to the updates to the assumptions used in the option pricing models.

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Basis of Presentation (Details) (USD $) In Thousands, except Share data, unless otherwise specified	9 Months Ended
	Sep. 30, 2012	Dec. 31, 2011	Sep. 30, 2011	Dec. 31, 2010
Basis of Presentation (Additional Textual) [Abstract]
Amount paid upon exercise of redemption rights	$ 5,667	$ 5,116
Accumulated deficit	(444,261)	(439,629)
Cash and cash equivalents	$ 3,363	$ 5,040	$ 5,502	$ 6,866
Securities Purchase Agreement date	May 24, 2010
Number of trading days	3 days
Common stock, par value	$ 0.0001
Percentage of issued and outstanding common stock	9.999%
Asset Purchase Agreement Date	January 19 2013
Series of C-12 stock , Period of business days	10 days
Maximum [Member]
Basis of Presentation (Textual) [Abstract]
Conversion Cap of Preferred Stock	3.76%
Minimum [Member]
Basis of Presentation (Textual) [Abstract]
Conversion Cap of Preferred Stock	0.00%
Series C-1 Preferred Stock [Member]
Basis of Presentation (Textual) [Abstract]
Number of shares possibly redeemable that is equal to or lesser than Series C-1	2,900

XML

Fair Value of Financial Instruments (Tables)

9 Months Ended

Sep. 30, 2012

Fair Value of Financial Instruments [Abstract]

Estimated fair values of the liabilities measured on a recurring basis

	Fair Value Measurements at September 30, 2012
	Balance at September  30, 2012		Quoted Prices in Active  Markets (Level 1)		Significant  Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Embedded derivative liabilities	$	3,900	$	—	$	—	$	3,900
Warrant derivative liabilities		8,817		—		—		8,817
Total	$	12,717	$	—	$	—	$	12,717

	Fair Value Measurements at December 31, 2011
	Balance at December 31, 2011		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Embedded derivative liabilities	$	3,680	$	—	$	—	$	3,680
Warrant derivative liabilities		11,590		—		—		11,590
Total	$	15,270	$	—	$	—	$	15,270

Liabilities measured at estimated fair value using unobservable inputs

	Fair Value Measurements Using Significant Unobservable Inputs (Levels 3)
	Embedded  Derivative Liabilities		Warrant  Derivative Liabilities			Total
Beginning balance at December 31, 2011	$	3,680	$	11,590		$	15,270
Adjustment to estimated fair value		77		(2,773	)		(2,696	)
Accrued dividends payable in Series C-1 2 Preferred		143		—			143
Ending balance at September 30, 2012	$	3,900	$	8,817		$	12,717

	Fair Value Measurements Using Significant Unobservable Inputs (Levels 3)
	Embedded  Derivative Liabilities			Warrant Derivative Liabilities			Total
Beginning balance at December 31, 2010	$	5,170		$	932		$	6,102
Adjustment to estimated fair value		(1,620	)		(1,726	)		(3,346	)
Decrease of the embedded derivative liabilities for preferred shares converted into common stock		(315	)		—			(315	)
Forfeited accrued dividends payable in Series C-1 2 Preferred		(72	)		—			(72	)
Accrued dividends payable in Series C-1 1 Preferred		3			—			3
Ending balance at September 30, 2011	$	3,166		$	(794	)	$	2,372

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401(k) Plan

9 Months Ended

Sep. 30, 2012

401(k) Plan [Abstract]

401(k) Plan

10. 401(k) Plan

During September 2010, the Company adopted the La Jolla Pharmaceutical Company Retirement Savings Plan
(the “401(k) Plan”), which qualifies under Section 401(k) of the Internal Revenue Code of 1986, as amended (the “Code”).
The 401(k) Plan is a defined contribution plan established to provide retirement benefits for employees and is employee funded up to an elective annual deferral. The 401(k) Plan is available for all employees who have completed one year of service with the Company.

Following guidance in IRS Notice 98-52 related to the “safe harbor,” 401(k) plan method, non-highly compensated employees will receive a contribution from the Company equal to 3% of their annual salaries, as defined in the Code. Such contributions vest immediately and are paid annually following each year end. These “safe harbor” contributions by the Company were less than $8,000 for the year ended December 31, 2011. The contribution was paid during April 2012.

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Stockholders' Equity

9 Months Ended

Sep. 30, 2012

Stockholders' Equity [Abstract]

Stockholders' Equity

8. Stockholders’ Equity

Warrants

In connection with the Company’s public offering of shares of Common Stock and warrants to purchase shares of Common Stock in May 2008, the Company issued warrants to purchase 390 shares of the Company’s Common Stock. The warrants were immediately exercisable upon grant, have an exercise price of $2,150 per share and remain exercisable for five years. As of September 30, 2012, all of these warrants were outstanding and 390 shares of common stock are reserved for issuance upon exercise of the warrants.

Share-Based Compensation

In June 1994, the Company adopted the La Jolla Pharmaceutical Company 1994 Stock Incentive Plan (the “1994 Plan”), under which, as amended, 164 shares of common stock were authorized for issuance. The 1994 Plan expired in June 2004 with no shares available for future grants, and there were 8 options outstanding under the 1994 Plan as of September 30, 2012.

In May 2004, the Company adopted the La Jolla Pharmaceutical Company 2004 Equity Incentive Plan (the “2004 Plan”), under which, as amended, 640 shares of common stock have been authorized for issuance. The 2004 Plan provides for the grant of incentive and non-qualified stock options, as well as other share-based payment awards, to employees, directors, consultants and advisors of the Company with up to a 10-year contractual life and various vesting periods as determined by the Company’s Compensation Committee or the Board of Directors, as well as automatic fixed grants to non-employee directors of the Company. As of September 30, 2012, there were a total of 75 options outstanding under the 2004 Plan and 537 shares remained available for future grant.

In August 2010, the Company adopted the 2010 Plan. The 2010 Plan is similar to the 2004 Plan, other than with regard to the number of shares authorized for issuance. On May 22, 2012, the 2010 Plan was amended to reset the authorized number of shares for issuance to a total of 1,188,414 shares, representing 10% of the number of shares of common stock issued and outstanding on April 11, 2012 (the record date used in connection with the Company’s annual proxy). This number of shares is initially reserved for issuance and is subject to quarterly upward adjustment so that the total number of shares reserved under the 2010 Plan will, on the first day of each calendar quarter, be equal to 10% of the common stock issued and outstanding as of the last day of the prior calendar quarter. The adjustments continue through the quarter ending June 30, 2015 (resulting in a final adjustment on July 1, 2015). In no event will the number of shares potentially issuable under the 2010 Plan exceed 676,640,705, which represents 10% of the number of shares of common stock potentially outstanding on a fully-diluted and as-converted basis on April 11, 2012, after giving effect to the potential conversion of the convertible preferred stock that was issued and outstanding on April 11, 2012. Effective as of July 1, 2012, the Company authorized 47,804 additional shares for issuance based on 10% of the number of shares of common stock outstanding on June 30, 2012. As of September 30, 2012, there were a total of 16 options outstanding and 1,236,202 shares remained available for future grant. Effective as of October 1, 2012, the Company authorized 120,520 additional shares for issuance based on 10% of the number of shares of common stock outstanding on September 30, 2012.

On April 10, 2012, the Company awarded options to purchase up to 592,230,471 shares of common stock to the President and Chief Executive Officer, a board member and an employee. The inducement options were granted outside of the 2010 Plan, but they are subject to the terms and conditions of the 2010 Plan. The inducement options were granted at an exercise price of $0.06 and two of the grants vest with respect to 25% of the underlying shares on a specified one-year anniversary date, with the remainder vesting monthly, in equal monthly installments, over the three years thereafter. The grant made to a board member vests on a quarterly basis over a one-year period (see note 9).

A summary of the Company’s stock option activity and related data for the nine months ended September 30, 2012 follows:

	Outstanding Options
	Number of Shares			Weighted-Average Exercise  Price
Balance at December 31, 2011		894		$	17,462
Grant		592,230,471		$	0.06
Forfeited/Expired		(795	)	$	11,420
Balance at September 30, 2012		592,230,570		$	0.067

As of September 30, 2012, options exercisable have a weighted-average remaining contractual term of 9.53 years. No stock option exercises occurred during the year ended December 31, 2011. As of September 30, 2012 and December 31, 2011, the total intrinsic value, which is the difference between the exercise price and closing price of the Company’s common stock for options outstanding and exercisable, was $0.

	September 30, 2012				December 31, 2011
	Options		Weighted-Average Exercise Price		Options		Weighted-Average Exercise Price
Exercisable at end of period		9,453,848	$	0.5012		585	$	26,243
Weighted-average fair value of options granted during the period	$	0.06			$	—

Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock) as of September 30, 2012 were:

Options Outstanding	Range of Exercise Prices	Weighted- Average Remaining Contractual Life (in years)	Weighted- Average Exercise Price		Options Exercisable		Weighted- Average Price of Options Exercisable
592,230,471	$0.06	9.53	$	0.06		9,453,749	$	0.06
55	$210 - $21,500	7.11	$	4,876		55	$	4,876
10	$39,900	3.63	$	39,900		10	$	39,900
11	$42,000	3.03	$	42,000		11	$	42,000
1	$52,600	3.45	$	52,600		1	$	52,600
10	$59,700	4.65	$	59,700		10	$	59,700
5	$148,000	1.64	$	148,000		5	$	148,000
2	$148,500	0.61	$	148,500		2	$	148,500
2	$235,500	0.97	$	235,500		2	$	235,500
3	$295,000	0.14	$	295,000		3	$	295,000
592,230,570	$0.06-$295,000	9.53	$	0.067		9,453,848	$	0.5012

At September 30, 2012, the Company has reserved 593,467,889 shares of common stock for future issuance upon exercise of options granted or to be granted under the 1994, 2004 and 2010 Plans, as well as for inducement options granted outside of the Company’s equity compensation plans.

The following table summarizes share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category (in thousands):

	Three Months Ended September 30,				Nine Months Ended Spetember 30,
	2012		2011		2012		2011
Research and development	$	279	$	—	$	526	$	—
General and administrative		2,683		63		5,146		194
Share-based compensation expense included in operating expenses	$	2,962	$	63	$	5,672	$	194

The Company determines the fair value of share-based payment awards on the date of grant using the Black-Scholes option-pricing model, which is affected by the Company’s stock price as well as assumptions regarding a number of highly complex and subjective variables. Option pricing models were developed for use in estimating the value of traded options that have no vesting or hedging restrictions and are fully transferable. Although the fair value of employee and director stock options granted by the Company is determined using an option pricing model, that value may not be indicative of the fair value observed in a willing-buyer/willing-seller market transaction.

The Company estimated the fair value of each option grant on the date of grant using the Black-Scholes option-pricing model with the following weighted-average assumptions:

	Three Months  Ended September 30,						Nine Months  Ended September 30,
Option:	2012			2011			2012			2011
Risk-free interest rate		—	%		—	%		1.10	%		—	%
Dividend yield		—	%		—	%		0.0	%		—	%
Volatility		—	%		—	%		236	%		—	%
Expected life (years)		—			—			6.04			—

The remaining unamortized share-based compensation expense related to stock options as of September 30, 2012 is $30,428,000. The remaining expense of the inducement option issued to the board member totaling $444,000 will be recognized over four months, ending in January 2013. The remaining expense of the inducement options issued to the President and Chief Executive Officer and an employee totaling $29,984,000, will be recognized over approximately 40 months, ending in January 2016.

Employee Stock Purchase Plan

Effective August 1, 1995, the Company adopted the 1995 Employee Stock Purchase Plan, or ESPP, under which shares of common stock are reserved for sale to eligible employees, as defined in the ESPP. Employees may purchase common stock under the ESPP every three months (up to but not exceeding 10% of each employee’s base salary or hourly compensation, and any cash bonus paid, subject to certain limitations) over the offering period at 85% of the fair market value of the common stock at specified dates. The offering period may not exceed 24 months. At the Annual Meeting of Stockholders held on August 12, 2010, the stockholders approved an amendment to the ESPP to extend the term thereof from 2015 to 2025 and to increase the shares of common stock authorized for issuance hereunder from 85 to 485. As of September 30, 2012, 72 shares of common stock have been purchased under the ESPP and 413 shares of common stock are available for future issuance. No shares were issued under the ESPP during the year ended December 31, 2011 or for the nine months ended September 30, 2012.

Restricted Stock

In April 2012, the Company issued restricted common stock to the President and Chief Executive Officer, a board member and an employee. The shares were issued outside of the 2010 Plan but are subject to the terms and conditions of the 2010 Plan. The total restricted shares are 2,987,850 and the stock will vest as of January 19, 2013, so long as the holders of the Series C-1² Preferred have not elected to redeem their holdings (see Note 4). If the services of the holder are terminated during the vesting period, the shares are subject to a reacquisition right. No consideration is paid for the redemption of the shares under the reacquisition right, but the holder is required to return to the Company any cash dividends paid or payable with respect to the shares. The grant date fair value is the market value on the grant date multiplied by the number of shares granted and share-based compensation expense is recognized on a straight-line basis over the vesting period. The share-based compensation expense during the three months and nine months ended September 30, 2012 by expense category was $46,000 and $86,000 for general and administrative expenses and $12,000 and $23,000 for research and development expenses, respectively. The remaining unamortized share-based compensation expense to be recognized over the next four months is $70,000.

Restricted Stock Units

On April 10, 2012, the Company granted restricted stock units (“RSUs”) of 14,219 units to an employee and 10,360,892 units to a board member, where each RSU represents a contingent right to receive one share of the Company’s common stock. The RSUs are to vest according to a defined schedule in each agreement. Upon the designated vesting dates, the holders will receive common stock of the Company. The RSUs for the board member vest quarterly beginning on April 20, 2012 and ending on January 20, 2013. Twenty-five percent of the RSUs for the employee vest on January 19, 2013 with the remainder vesting monthly thereafter for 36 months.

On August 17, 2012, the Company granted RSUs of 2,700,000 units to two consultants of the Company, where each RSU represents a contingent right to receive one share of the Company’s common stock. The RSUs are to vest according to a defined schedule in each agreement. Upon the designated vesting dates, the holders will receive common stock of the Company. The RSUs for one consultant vest monthly beginning on August 20, 2012 and ending on January 20, 2012. Forty-five and one half percent (45.5%) of the RSUs for the second consultant vest on August 20, 2012 and the remainder vest monthly after that date until January 20, 2013.

Stock-based compensation cost of RSUs is measured by the market value of the Company’s common stock on the date of grant. The grant date value of awards granted is amortized on a straight-line basis over the requisite service periods of the awards, which are the vesting periods. The weighted average grant date value was $0.06 per RSU for the April 10, 2012 grants and $0.069 per RSU for the August 17, 2012 grants. The share-based compensation expense during the three months and nine months ended September 30, 2012 by expense category is

$159,000 and $439,000 for general and administrative expenses and $55 and $151 for research and development expenses, respectively. The remaining unamortized share-based compensation expense to be recognized over the next four months is $184,000 for the board member RSUs, $702 to be recognized over the remaining service period for the employee RSUs, and $81,000 to be recognized over the remaining service period for the consultant RSUs.

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Employment Agreements

9 Months Ended

Sep. 30, 2012

Employment Agreements [Abstract]

Employment Agreements

9. Employment Agreements

As part of the Asset Purchase Agreement described in Note 1, the Company entered into an Employee Agreement with a new President and Chief Executive Officer on January 19, 2012. The annual base salary will be $240,000 for the first year of employment with the Company and will increase to $420,000 on the one-year anniversary of the employment start date. In addition, on April 10, 2012, an option to purchase up to 506,300,087 shares of common stock (the “First Option”) was awarded to the President and Chief Executive Officer, subject to the terms and conditions of any applicable award agreements and other restrictions and limitations generally applicable to common stock or equity awards held by Company executives or otherwise imposed by law. Subject to applicable terms and conditions, the First Option vests with respect to 25% of the underlying shares on the one-year anniversary of the employment start date, with the remainder vesting monthly, in equal monthly installments, over the three years thereafter. The First Option is exercisable at a price equal to the fair market value of a share of common stock on the date of the grant of the First Option. An additional option will be awarded to the President and Chief Executive Officer to purchase the number of shares of common stock equal to 7.5% of the Company’s fully diluted, as-converted shares on the second anniversary of the employment start date, less the number of shares subject to the First Option on the First Option grant date (the “Second Option”), and the Second Option will also be subject to the same terms and conditions as the First Option. Subject to applicable terms and conditions, 50% of the underlying shares of the Second Option will be fully vested on the date of the grant with the remainder vesting monthly, in equal monthly installments, over the two years thereafter. The Second Option will be exercisable at a price equal to the fair market value of a share of common stock on the date of the grant of the Second Option.

On January 19, 2012, effective upon the closing of the Asset Purchase Agreement, the former President and Chief Executive Officer and the former Chief Financial Officer resigned. Both of the Company’s aforementioned officers entered into separation agreements with the Company, and the Company agreed to make separation payments of $78,000 and $62,000 respectively. Further, both officers relinquished their rights to all Company stock options, whether vested or unvested.

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Net Income (Loss) per Share

9 Months Ended

Sep. 30, 2012

Net Income (Loss) per Share [Abstract]

Net Income (Loss) per Share

11. Net Income (Loss) per Share

The following table sets forth the computation of basic and diluted EPS (in thousands, except per share amounts):

	Three Months Ended September 30,						Nine Months Ended September 30,
	2012			2011			2012			2011
Numerator
Net income (loss)	$	(2,222	)	$	3,570		$	(4,632	)	$	1,775
Preferred stock dividends forfeited (earned)		(205	)		(3	)		(281	)		75
Numerator for basic EPS – net income (loss) attributable to common stockholders		(2,427	)		3,567			(4,913	)		1,850
Effect of dilutive securities:
Preferred stock dividends		—			—			—			—
Numerator for diluted EPS – net income (loss) attributable to common stockholders	$	(2,427	)	$	3,567		$	(4,913	)	$	1,850
Denominator:
Weighted-average shares outstanding
Basic EPS		13,253			533			8,995			224
Effect of dilutive convertible preferred stock and warrants		—			12,347			—			48,472
Denominator for diluted EPS		13,253			12,880			8,995			48,696
Basic EPS	$	(0.18	)	$	6.69		$	(0.55	)	$	8.25
Diluted EPS	$	(0.18	)	$	0.28		$	(0.55	)	$	0.04

At September 30, 2012 and 2011, the potentially dilutive securities include 5.4 billion and 44 million shares, respectively, reserved for the exercise of outstanding stock options and warrants.

At September 30, 2011, potentially dilutive securities of approximately 1,249 shares reserved for the exercise of outstanding stock options and warrants for common stock were excluded from the diluted EPS computation because their effect was anti-dilutive.

The Series C-1 ² Preferred was convertible into 1.2 billion and 8.6 million shares at September 30, 2012 and 2011, respectively. The Series D-1² Preferred was convertible into 766 million shares at September 30, 2012.

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Securities Purchase Agreement (Details Textual) (USD $)	1 Months Ended		9 Months Ended			1 Months Ended					9 Months Ended		9 Months Ended	1 Months Ended				1 Months Ended		1 Months Ended				1 Months Ended
	Mar. 31, 2011	May 31, 2010	Sep. 30, 2012 Rate	Dec. 31, 2011	May 24, 2010	Mar. 31, 2011 Maximum [Member]	Mar. 31, 2011 Minimum [Member]	Sep. 30, 2012 Minimum [Member]	Sep. 30, 2012 Series C-2 Warrants [Member]	Dec. 31, 2011 Series C-2 Warrants [Member]	Sep. 30, 2012 Series D-1 Warrants [Member]	Dec. 31, 2011 Series D-1 Warrants [Member]	Sep. 30, 2012 Series D-2 Warrants [Member]	May 31, 2010 Series C-1 Preferred [Member]	Sep. 30, 2012 Series C-1 Preferred [Member]	Sep. 30, 2011 Series C-1 Preferred [Member]	May 24, 2010 Series C-1 Preferred [Member]	May 31, 2010 Series C-2 Preferred [Member]	May 24, 2010 Series C-2 Preferred [Member]	May 31, 2010 Series D-1 Preferred [Member]	Sep. 30, 2012 Series D-1 Preferred [Member]	May 24, 2010 Series D-1 Preferred [Member]	May 24, 2010 Series D-2 Preferred [Member]	May 31, 2010 Common Stock [Member]
Securities Purchase Agreement (Textual) [Abstract]
Aggregate of common shares of company														5,134						5,134				2,897
Preferred stock, par value			$ 0.0001	$ 0.0001													$ 0.0001					$ 0.0001
Number of warrants series C2 to be purchased																		10,268
Preferred stock par value in Series C-1 Preferred			$ 0.0001																$ 0.0001				$ 0.0001
Increased number of warrants						10,646	10,268
Total value of the embedded derivative			$ 3,900,000	$ 3,680,000						$ 9,051,000		$ 2,539,000
Warrants Revalued									8,246,000		571,000
Non-cash other income on the decrease in the estimated fair value of the embedded derivatives			805,000								1,968,000
Decrease in warrants value due to exercise											3,611
Increase in the value of series D-2 warrants													198,000
Shares of Series C1 Preferred into common stock															1,200,000,000	8,600,000					766,000,000
Minimum preferred stock outstanding if warrants are exercised								3,000
Preferred stock outstanding								1,000
Carrying value of Series C-1															5,800,000
Securities Purchase Agreement (Additional Textual) [Abstract]
Percentage of investment of proceeds contributed by employee maximum		3.00%
Proceeds from issuance of derivative obligations		6,003,000
Common stock, par value					$ 0.0001
Common stock, stated price					$ 300
Proceeds from preferred stock per share					$ 1,000
Exercise price series D1 warrants preferred		$ 1,000
Exercise price series C2 warrants preferred		1,000
Exercise Price Series D Two Warrants Preferred		$ 1,000
Additional cash payment for right to receive Series C2 Preferred after milestones	236,000
Mandatory exercise of warrants upon achievement of the Preclinical Milestone	7,452,000
Mandatory exercise of warrants upon achievement of the Clinical milestone	3,194,000
Cumulative dividends payable			15.00%
Percentage of preferred stock dividends payable			5.00%
Initial conversion ratio of new preferred stock to common stock			66,667
Conversion price percentage of new preferred stock			10.00%
Net increase in liability due to accrual of dividends			143,000
Preferred stock, liquidation preference price per share			$ 1,000
Non-cash income on increase in estimated fair value of the Embedded Derivatives			$ 77,000
Number of share holder right to redeemed price per share			$ 1,000
Price per share of common stock discounted from the closing market prices			$ 0.06	$ 0.27

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Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2012

Stockholders' Equity [Abstract]

Summary of stock option activity and related data

	Outstanding Options
	Number of Shares			Weighted-Average Exercise  Price
Balance at December 31, 2011		894		$	17,462
Grant		592,230,471		$	0.06
Forfeited/Expired		(795	)	$	11,420
Balance at September 30, 2012		592,230,570		$	0.067

Schedule of share based compensation related to options exercisable and weighted average

	September 30, 2012				December 31, 2011
	Options		Weighted-Average Exercise Price		Options		Weighted-Average Exercise Price
Exercisable at end of period		9,453,848	$	0.5012		585	$	26,243
Weighted-average fair value of options granted during the period	$	0.06			$	—

Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)

Options Outstanding	Range of Exercise Prices	Weighted- Average Remaining Contractual Life (in years)	Weighted- Average Exercise Price		Options Exercisable		Weighted- Average Price of Options Exercisable
592,230,471	$0.06	9.53	$	0.06		9,453,749	$	0.06
55	$210 - $21,500	7.11	$	4,876		55	$	4,876
10	$39,900	3.63	$	39,900		10	$	39,900
11	$42,000	3.03	$	42,000		11	$	42,000
1	$52,600	3.45	$	52,600		1	$	52,600
10	$59,700	4.65	$	59,700		10	$	59,700
5	$148,000	1.64	$	148,000		5	$	148,000
2	$148,500	0.61	$	148,500		2	$	148,500
2	$235,500	0.97	$	235,500		2	$	235,500
3	$295,000	0.14	$	295,000		3	$	295,000
592,230,570	$0.06-$295,000	9.53	$	0.067		9,453,848	$	0.5012

Summary of share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category

	Three Months Ended September 30,				Nine Months Ended Spetember 30,
	2012		2011		2012		2011
Research and development	$	279	$	—	$	526	$	—
General and administrative		2,683		63		5,146		194
Share-based compensation expense included in operating expenses	$	2,962	$	63	$	5,672	$	194

Fair value of each option grant on the date of grant using the Black-Scholes option-pricing model

	Three Months  Ended September 30,						Nine Months  Ended September 30,
Option:	2012			2011			2012			2011
Risk-free interest rate		—	%		—	%		1.10	%		—	%
Dividend yield		—	%		—	%		0.0	%		—	%
Volatility		—	%		—	%		236	%		—	%
Expected life (years)		—			—			6.04			—

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Fair Value of Financial Instruments (Details 1) (USD $) In Thousands, unless otherwise specified	9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011
Liabilities measured at estimated fair value using unobservable inputs
Beginning balance	$ 15,270	$ 6,102
Adjustments to estimated fair value	(2,696)	(3,346)
Decrease of the embedded derivative liabilities for preferred shares converted into common stock		(315)
Ending balance	12,717	2,372
Series C-1 Preferred Stock [Member]
Liabilities measured at estimated fair value using unobservable inputs
Forfeited accrued dividends payable in Series C-12 Preferred		(72)
Accrued dividends payable in Series C-1 Preferred	143	3
Embedded Derivative [Member]
Liabilities measured at estimated fair value using unobservable inputs
Beginning balance	3,680	5,170
Adjustments to estimated fair value	77	(1,620)
Decrease of the embedded derivative liabilities for preferred shares converted into common stock		(315)
Ending balance	3,900	3,166
Embedded Derivative [Member] | Series C-1 Preferred Stock [Member]
Liabilities measured at estimated fair value using unobservable inputs
Forfeited accrued dividends payable in Series C-12 Preferred		(72)
Accrued dividends payable in Series C-1 Preferred	143	3
Warrant Derivative [Member]
Liabilities measured at estimated fair value using unobservable inputs
Beginning balance	11,590	932
Adjustments to estimated fair value	(2,773)	(1,726)
Decrease of the embedded derivative liabilities for preferred shares converted into common stock
Ending balance	8,817	(794)
Warrant Derivative [Member] | Series C-1 Preferred Stock [Member]
Liabilities measured at estimated fair value using unobservable inputs
Forfeited accrued dividends payable in Series C-12 Preferred
Accrued dividends payable in Series C-1 Preferred

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Stockholders' Equity (Details Textual) (USD $)	1 Months Ended	3 Months Ended		9 Months Ended		12 Months Ended				3 Months Ended	9 Months Ended	3 Months Ended		9 Months Ended					3 Months Ended	9 Months Ended	3 Months Ended	9 Months Ended	1 Months Ended		9 Months Ended		3 Months Ended	9 Months Ended	3 Months Ended	9 Months Ended									9 Months Ended	12 Months Ended		9 Months Ended
	Apr. 30, 2012	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011	Dec. 31, 2011	Apr. 11, 2012	Apr. 10, 2012	May 31, 2008	Sep. 30, 2012 Research and development [Member]	Sep. 30, 2012 Research and development [Member]	Sep. 30, 2012 General and administrative [Member]	Sep. 30, 2011 General and administrative [Member]	Sep. 30, 2012 General and administrative [Member]	Sep. 30, 2011 General and administrative [Member]	Sep. 30, 2012 Director [Member]	Sep. 30, 2012 President and Chief Executive Officer and Employee [Member]	Sep. 30, 2012 Restricted Stock [Member]	Sep. 30, 2012 Restricted Stock [Member] Research and development [Member]	Sep. 30, 2012 Restricted Stock [Member] Research and development [Member]	Sep. 30, 2012 Restricted Stock [Member] General and administrative [Member]	Sep. 30, 2012 Restricted Stock [Member] General and administrative [Member]	Aug. 31, 2012 Restricted Stock Units [Member]	Apr. 30, 2012 Restricted Stock Units [Member]	Sep. 30, 2012 Restricted Stock Units [Member]	Aug. 20, 2012 Restricted Stock Units [Member]	Sep. 30, 2012 Restricted Stock Units [Member] Research and development [Member]	Sep. 30, 2012 Restricted Stock Units [Member] Research and development [Member]	Sep. 30, 2012 Restricted Stock Units [Member] General and administrative [Member]	Sep. 30, 2012 Restricted Stock Units [Member] General and administrative [Member]	Sep. 30, 2012 Restricted Stock Units [Member] Director [Member]	Apr. 10, 2012 Restricted Stock Units [Member] Director [Member]	Sep. 30, 2012 Restricted Stock Units [Member] Employee [Member]	Apr. 10, 2012 Restricted Stock Units [Member] Employee [Member]	Sep. 30, 2012 Restricted Stock Units [Member] Consultant [Member]	Aug. 17, 2012 Restricted Stock Units [Member] Consultant [Member]	Aug. 12, 2010 Maximum [Member]	Aug. 12, 2010 Minimum [Member]	Sep. 30, 2012 ESPP [Member]	Dec. 31, 2011 ESPP [Member]	Sep. 30, 2012 1994 Plan [Member]	Sep. 30, 2012 2004 Plan [Member]	Oct. 01, 2012 2010 Plan [Member]	Sep. 30, 2012 2010 Plan [Member]	Apr. 11, 2012 2010 Plan [Member]
Stockholders' Equity (Textual) [Abstract]
Common Stock authorized for issuance		12,008,000,000		12,008,000,000		6,008,000,000																																			164	640		1,188,414
Options outstanding		592,230,570		592,230,570		894																																			8	75		16
Shares remaining available for grants																																									0	537		1,236,202
Period of share-based payment awards																									36 months																	10 years
Additional common shares authorized																																											120,520	47,804	676,640,705
Maximum percentage of the base salary of which an employee can purchase common stock																																							10.00%
Common stock are reserved for issuance upon exercise of the warrants		390		390																																					593,467,889	593,467,889		593,467,889
Unamortized share-based compensation expense																		$ 70,000													$ 184,000		$ 702
Share-based compensation expense option issued																4 months	40 months								4 months
Increase in the shares of common stock authorized for issuance under the Employee Stock Purchase Plan																																					485	85
Share-based compensation expense		2,962,000	63,000	5,672,000	194,000					279,000	526,000	2,683,000	63,000	5,146,000	194,000				12,000	23,000	46,000	86,000					55	151	159,000	439,000
Restricted stock units granted																																10,360,892		14,219		2,700,000
Contingent right to receive share of common stock																									1
Percentage of RSUs for employee vest																									25.00%	45.50%
Restricted stock units weighted average grant date value																							$ 0.069	$ 0.06
Shares issued under Employee Stock Purchase Plan																																							0	0
Shares of common stock issued and outstanding							10.00%
Unamortized share-based compensation expense		30,428,000		30,428,000												444,000	29,984,000																		81,000
Stockholders' Equity (Additional Textual) [Abstract]
Issued warrants to purchase shares									390
Exercise price of Warrants granted		2,150		2,150
Term of common stock warrants				5 years
Outstanding warrants		390		390
Common stock offered for purchase to employee								592,230,471
Options granted at exercise price								$ 0.06
Percentage of grants vesting at one year anniversary of option award								25.00%
Options exercisable have a weighted-average remaining contractual term				9 years 6 months 11 days
Common stock for options outstanding and exercisable intrinsic value		0		0		0
Percentage of common stock market value used for purchase price of Employee Stock Purchase Plan		85.00%		85.00%
Maximum offer period for share purchase				24 months
Shares issued under the Employee Stock Purchase Plan		0		0		0
Purchase of common stock, shares		72		72
Common stock available for future issuance		413		413
Restricted shares	2,987,850
Vesting period of two grants				3 years
Vesting period of the other grant				1 year
Stock option exercises						$ 0
Restricted shares vesting date		Jan. 19, 2013		Jan. 19, 2013

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Condensed Statements of Cash Flows (Unaudited) (USD $) In Thousands, unless otherwise specified	9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011
Operating activities:
Net loss	$ (4,632)	$ 1,775
Adjustments to reconcile net loss to net cash used for operating activities:
Share-based compensation expense	5,672	194
Gain on adjustments to fair value of derivative liabilities	(2,696)	(3,346)
Change in operating assets and liabilities:
Prepaids and other current assets	20	58
Accounts payable	60	(16)
Accrued expenses	(112)	(27)
Accrued payroll and related expenses	11	(2)
Net cash used for operating activities	(1,677)	(1,364)
Net decrease in cash and cash equivalents	(1,677)	(1,364)
Cash and cash equivalents at beginning of period	5,040	6,866
Cash and cash equivalents at end of period	3,363	5,502
Supplemental schedule of noncash investing and financing activities:
Issuance of preferred stock	3,611
Conversion of preferred stock into common stock	46	748
Reclassification of preferred stock currently redeemable		5,532
Preferred stock dividend forfeited (earned)	(281)	75
Payment of preferred stock dividends	(374)
Forfeiture of preferred stock dividends		$ 75

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GliaMed Asset Purchase

9 Months Ended

Sep. 30, 2012

GliaMed Asset Purchase [Abstract]

GliaMed Asset Purchase

5. GliaMed Asset Purchase

In March 2011, the Company and Jewel Merger Sub acquired assets related to certain RIL compounds from GliaMed. The Compounds were acquired pursuant to the Asset Agreement for a nominal amount, and if certain milestones noted below were met, the Company would have paid GliaMed additional consideration of up to 8,205 shares of newly designated convertible Series E Preferred, which would have been convertible into approximately 20% of the Company’s fully diluted outstanding common stock on an as-converted basis. The issuance of the shares was tied to the achievement of certain development and regulatory milestones. GliaMed was also eligible to receive a cash payment from the Company of $5,000,000 if a Compound was approved by the FDA or EMA in two or more clinical indications.

In late May 2011, the Company received final data from the Company’s clinical research organization, which showed that the predetermined study endpoints, as set forth in the Asset Agreement, were not met and that the LJP1485 compound did not show statistically significant improvement in the study endpoints as compared to vehicle (placebo).

The purchase was originally recorded as a long-term other asset for the intangible rights received related to the Compounds equal to the nominal amount paid to GliaMed plus the asset acquisition costs incurred for legal services and due diligence related to the investigation of the underlying technology. As a result of the negative results in the confirmatory preclinical study in May 2011, the Company discontinued the development of LJP1485 in May 2011 and in June 2011 the Company sold the Compounds back to GliaMed by selling all of the outstanding capital stock of Jewel Merger Sub to GliaMed for the same nominal amount that it had paid for the Compounds.

Jewel Merger Sub had no other assets or liabilities other than those relating to the Compounds and related assets and contract rights.

As part of this asset purchase, the Company designated five new series of preferred stock on March 30, 2011: its Series C-1¹ Stock, Series C-2¹ Stock, Series D-1¹ Stock, Series D-2¹ Stock (collectively, the “New Preferred Stock”) and Series E Preferred Stock. It exchanged on a one-for-one exchange ratio each share of its existing Series C-1 Preferred Stock that was outstanding for a new share of Series C-1¹ Stock. Each holder of New Preferred Stock and Series E Preferred Stock may convert its shares into common stock subject to a weekly conversion cap and certain common stock ownership limits.

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Fair Value of Financial Instruments (Details Textual) (USD $)	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Fair Value of Financial Instruments (Textual) [Abstract]
Net decrease in the estimated fair value of derivative liabilities	$ 1,227,000	$ 3,993,000	$ 2,696,000	$ 3,346,000

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Stockholders' Equity (Details 2) (USD $)	9 Months Ended
	Sep. 30, 2012
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Weighted-Average Remaining Contractual Life (Years)	5 years
Range 1 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	592,230,471
Range of Exercise Prices	0.06
Weighted-Average Remaining Contractual Life (Years)	9 years 6 months 11 days
Weighted-Average Exercise Price	0.06
Options Exercisable	9,453,749
Weighted-Average Exercise Price of Options Exercisable	0.06
Range 2 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	55
Weighted-Average Remaining Contractual Life (Years)	7 years 1 month 10 days
Weighted-Average Exercise Price	4,876
Options Exercisable	55
Weighted-Average Exercise Price of Options Exercisable	4,876
Range 3 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	10
Range of Exercise Prices	39,900
Weighted-Average Remaining Contractual Life (Years)	3 years 7 months 17 days
Weighted-Average Exercise Price	39,900
Options Exercisable	10
Weighted-Average Exercise Price of Options Exercisable	39,900
Range 4 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	11
Range of Exercise Prices	42,000
Weighted-Average Remaining Contractual Life (Years)	3 years 11 days
Weighted-Average Exercise Price	42,000
Options Exercisable	11
Weighted-Average Exercise Price of Options Exercisable	42,000
Range 5 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	1
Range of Exercise Prices	52,600
Weighted-Average Remaining Contractual Life (Years)	3 years 5 months 12 days
Weighted-Average Exercise Price	52,600
Options Exercisable	1
Weighted-Average Exercise Price of Options Exercisable	52,600
Range 6 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	10
Range of Exercise Prices	59,700
Weighted-Average Remaining Contractual Life (Years)	4 years 7 months 24 days
Weighted-Average Exercise Price	59,700
Options Exercisable	10
Weighted-Average Exercise Price of Options Exercisable	59,700
Range 7 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	5
Range of Exercise Prices	148,000
Weighted-Average Remaining Contractual Life (Years)	1 year 7 months 21 days
Weighted-Average Exercise Price	148,000
Options Exercisable	5
Weighted-Average Exercise Price of Options Exercisable	148,000
Range 8 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	2
Range of Exercise Prices	148,500
Weighted-Average Remaining Contractual Life (Years)	7 months 10 days
Weighted-Average Exercise Price	148,500
Options Exercisable	2
Weighted-Average Exercise Price of Options Exercisable	148,500
Range 9 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	2
Range of Exercise Prices	235,500
Weighted-Average Remaining Contractual Life (Years)	11 months 19 days
Weighted-Average Exercise Price	235,500
Options Exercisable	2
Weighted-Average Exercise Price of Options Exercisable	235,500
Range 10 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	3
Range of Exercise Prices	295,000
Weighted-Average Remaining Contractual Life (Years)	1 month 21 days
Weighted-Average Exercise Price	295,000
Options Exercisable	3
Weighted-Average Exercise Price of Options Exercisable	295,000
Range 11 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Options Outstanding	592,230,570
Weighted-Average Remaining Contractual Life (Years)	9 years 6 months 11 days
Weighted-Average Exercise Price	0.067
Options Exercisable	9,453,848
Weighted-Average Exercise Price of Options Exercisable	0.5012
Maximum [Member] | Range 2 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Range of Exercise Prices	21,500
Maximum [Member] | Range 11 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Range of Exercise Prices	295,000
Minimum [Member] | Range 2 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Range of Exercise Prices	210
Minimum [Member] | Range 11 [Member]
Exercise prices and weighted-average remaining contractual lives for the options outstanding (excluding shares of restricted stock)
Range of Exercise Prices	0.06

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Securities Purchase Agreement (Tables)

9 Months Ended

Sep. 30, 2012

Securities Purchase Agreement [Abstract]

Fair values of derivative liabilities

	Fair Value Measurement at
	September 30, 2012		December 31, 2011
Embedded Derivatives of Series C-1 2 Preferred (including dividends paid in Series C-1 2 Preferred)	$	3,707	$	3,628
Embedded Derivatives of accrued dividends payable in Series C-1 2 Preferred		193		52
Series D-1 2 Warrants		571		2,539
Series C-2 2 Warrants for:
Series C-2 2 Preferred		2,782		3,785
Series D-2 2 Warrants		5,464		5,266
	$	12,717	$	15,270

Embedded Derivatives

	September 30, 2012			December 31, 2011
Closing price per share of common stock	$	0.044		$	0.27
Conversion price per share	$	0.005		$	0.60
Volatility		98.2	%		88.0	%
Risk-free interest rate		0.58	%		0.83	%
Credit spread		19.8	%		20.9	%
Remaining expected lives of underlying securities (years)		4.8			5.0

Series D1 warrants using binomial option pricing

	September 30, 2012			December 31, 2011
Closing price per share of common stock	$	0.044		$	0.27
Conversion price per share	$	0.005		$	0.60
Volatility		74.8	%		67.5	%
Risk-free interest rate		0.23	%		0.28	%
Remaining expected lives of underlying securities (years)		2.5			2.2
Probability of Strategic Transaction		41	%		70	%

Series C2 warrants using binomial option pricing

	September 30, 2012			December 31, 2011
Closing price per share of common stock	$	0.044		$	0.27
Conversion price per share	$	0.005		$	0.60
Volatility		98.2	%		88.0	%
Risk-free interest rate		0.58	%		0.83	%
Credit spread		19.8	%		20.9	%
Remaining expected lives of underlying securities (years)		4.8			5.0
Time to exercise (months)		21			24