Equity Incentive Plans Equity Incentive Plan (Tables)

6 Months Ended

Jun. 30, 2020

Share-based Payment Arrangement [Abstract]

Equity award activity

The activity related to equity awards, which are comprised of stock options and inducement grants, during the six months ended June 30, 2020 is summarized as follows:

	Equity Awards		Weighted- average Exercise Price per Share		Weighted- average Remaining Contractual Term	Aggregate Intrinsic Value
Outstanding at December 31, 2019	5,616,840		$	19.50
Granted	806,923		$	5.27
Exercised	(94,219	)	$	6.42
Cancelled/forfeited	(2,883,533	)	$	19.43
Outstanding at June 30, 2020	3,446,011		$	16.59	5.87 years	$	35,037
Exercisable at June 30, 2020	2,144,609		$	20.84	4.27 years	$	—

Share-based compensation expense

The classification of share-based compensation expense is summarized as follows (in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2020		2019		2020		2019
Research and development	$	964	$	3,960	$	2,527	$	7,893
Selling, general and administrative	626		2,361		1,470		5,210
Total share-based compensation expense	$	1,590	$	6,321	$	3,997	$	13,103