Equity Incentive Plans Equity Incentive Plan (Tables)

3 Months Ended

Mar. 31, 2020

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Equity award activity

The activity related to equity awards, which are comprised of stock options and inducement grants, during the three months ended March 31, 2020 is summarized as follows:

	Equity Awards		Weighted- average Exercise Price per Share		Weighted- average Remaining Contractual Term	Aggregate Intrinsic Value
Outstanding at December 31, 2019	5,616,840		$	19.5
Granted	675,007		$	5.35
Exercised	(44,258	)	$	6.89
Cancelled/forfeited	(1,395,352	)	$	21.17
Outstanding at March 31, 2020	4,852,237		$	17.17	6.49 years	$	34,649
Exercisable at March 31, 2020	2,838,302		$	21.19	4.78 years	$	—

Share-based compensation expense

The classification of share-based compensation expense is summarized as follows (in thousands):

	Three Months Ended March 31,
	2020		2019
Research and development	$	1,563	$	3,899
Selling, general and administrative	844		2,812
Total share-based compensation expense	$	2,407	$	6,711