Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018
Operating activities
Net loss	$ (116,508)	$ (199,469)
Adjustments to reconcile net loss to net cash used for operating activities:
Share-based compensation expense	23,733	35,151
Depreciation and amortization expense	4,552	4,405
Loss on disposal of equipment	24	236
Non-cash interest expense	8,775	6,797
Non-cash rent expense	1,307	0
Changes in operating assets and liabilities:
Accounts receivable, net	(1,579)	(1,381)
Inventory, net	(191)	(2,020)
Prepaid expenses and other current assets	644	(1,964)
Accounts payable	(4,395)	(2,912)
Accrued expenses	395	5,451
Accrued payroll and related expenses	823	2,514
Lease liability	(2,530)	0
Deferred rent	0	824
Net cash used for operating activities	(84,950)	(152,368)
Investing activities
Purchase of property and equipment	(698)	(2,340)
Net cash used for investing activities	(698)	(2,340)
Financing activities
Net proceeds from issuance of common stock under ESPP	833	391
Net proceeds from issuance of common stock under 2013 Equity Plan	31	1,908
Net proceeds from royalty financing	0	124,289
Net proceeds from the issuance of common stock	0	109,809
Net cash provided by financing activities	864	236,397
Net (decrease) increase in cash and restricted cash	(84,784)	81,689
Cash and restricted cash at beginning of period	173,513	91,824
Cash and restricted cash at end of period	88,729	173,513
Supplemental disclosure of non-cash investing and financing activities
Conversion of Series F Convertible Preferred Stock into common stock	2,737	0
Initial recognition of right-of-use lease asset	16,798
Interest paid	1,999	506
Reconciliation of cash and restricted cash to the consolidated balance sheets
Total cash and restricted cash	$ 88,729	$ 173,513