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Restructuring (Details) - USD ($)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Restructuring Cost and Reserve [Line Items]    
Restructuring charges $ 4,900,000 $ 4,000,000
Reversal of non-cash-stock-based compensation expense 900,000 3,700,000
Payments for restructuring 900,000  
Restructuring costs 5,800,000  
Research and development [Member]    
Restructuring Cost and Reserve [Line Items]    
Restructuring charges 4,400,000 1,600,000
Selling, General and Administrative Expenses [Member]    
Restructuring Cost and Reserve [Line Items]    
Restructuring charges   2,400,000
Employee Severance    
Restructuring Cost and Reserve [Line Items]    
Restructuring charges 0 $ 7,700,000
Accrued Payroll    
Restructuring Cost and Reserve [Line Items]    
Restructuring charges $ 4,900,000