Unaudited Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018
Operating activities
Net loss	$ (91,275)	$ (154,051)
Adjustments to reconcile net loss to net cash used for operating activities:
Share-based compensation expense	19,522	29,126
Depreciation expense	3,408	3,245
Loss on disposal of equipment	15	236
Non-cash interest expense	6,971	4,421
Non-cash rent expense	969	0
Changes in operating assets and liabilities:
Accounts receivable, net	(36)	(1,537)
Inventory, net	110	(1,101)
Prepaid expenses and other current assets	328	(2,700)
Accounts payable	(3,234)	(4,914)
Accrued expenses	(332)	5,906
Accrued payroll and related expenses	(2,391)	(73)
Lease liability	(1,873)	0
Deferred rent	0	1,110
Net cash used for operating activities	(67,818)	(120,332)
Investing activities
Purchase of property and equipment	(679)	(2,252)
Net cash used for investing activities	(679)	(2,252)
Financing activities
Proceeds from the issuance of common stock under ESPP	661	0
Proceeds From Royalties Financing	0	124,289
Net proceeds from the issuance of common stock	0	109,809
Net proceeds from the exercise of stock options for common stock	0	1,908
Net cash provided by financing activities	661	236,006
Net (decrease) increase in cash and restricted cash	(67,836)	113,422
Cash and restricted cash at beginning of period	173,513	91,824
Cash and restricted cash at end of period	105,677	205,246
Supplemental disclosure of non-cash investing and financing activities:
Noncash Or Part Noncash Transaction, Conversion Of Preferred Stock, Common Stock	2,737	0
Initial recognition of right-of-use lease asset	16,798
Reconciliation of cash and restricted cash to the condensed consolidated balance sheets
Total cash and restricted cash	$ 173,513	$ 91,824