Unaudited Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenue
Net product sales	$ 5,706	$ 3,470	$ 15,804	$ 5,872
Total revenue	5,706	3,470	15,804	5,872
Operating expenses
Cost of product sales	554	256	1,605	443
Research and development	21,182	30,439	64,469	89,735
Selling, general and administrative	10,782	21,139	34,425	66,319
Total operating expenses	32,518	51,834	100,499	156,497
Loss from operations	(26,812)	(48,364)	(84,695)	(150,625)
Interest expense	(2,863)	(2,926)	(8,398)	(4,581)
Interest income	501	545	1,818	1,155
Total other expense, net	(2,362)	(2,381)	(6,580)	(3,426)
Net loss	$ (29,174)	$ (50,745)	$ (91,275)	$ (154,051)
Net loss per share, basic and diluted (usd per share)	$ (1.08)	$ (1.93)	$ (3.37)	$ (6.15)
Weighted-average common shares outstanding - basic and diluted (in shares)	27,135	26,226	27,093	25,055