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Deferred Royalty Obligation (Details) - USD ($)
3 Months Ended 9 Months Ended
May 10, 2018
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Debt Instrument [Line Items]            
Deferred royalty obligation, net   $ 124,366,000   $ 124,366,000   $ 124,323,000
Royalty Obligation Payable   600,000   600,000    
HealthCare Royalty Partners            
Debt Instrument [Line Items]            
Proceeds from royalty agreement $ 125,000,000          
Maximum potential royalty payout 180.00%          
Required payment for breach of agreement, payment one $ 125,000,000.0          
Required payment for breach of agreement, payment two 225,000,000.0          
HealthCare Royalty Partners | Loans Payable | Royalty Financing Agreement            
Debt Instrument [Line Items]            
Deferred royalty obligation, net 125,000,000 124,400,000   124,400,000    
Debt issuance costs $ 700,000          
Interest expense   2,800,000 $ 3,000,000 8,400,000 $ 4,600,000  
Unamortized debt discount   600,000   600,000    
Accrued interest expense   13,700,000   13,700,000   6,800,000
Royalty payments   600,000   1,400,000    
HealthCare Royalty Partners | Period One            
Debt Instrument [Line Items]            
Maximum potential royalty payout 10.00%          
HealthCare Royalty Partners | Period Two            
Debt Instrument [Line Items]            
Increase in maximum potential payout percent 4.00%          
HealthCare Royalty Partners | Payout Period            
Debt Instrument [Line Items]            
Increase in maximum potential payout percent 4.00%          
Other Noncurrent Liabilities | HealthCare Royalty Partners | Loans Payable | Royalty Financing Agreement            
Debt Instrument [Line Items]            
Accrued interest expense   $ 10,200,000   $ 10,200,000   $ 4,500,000