Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Current assets:
Cash	$ 104,768	$ 172,604
Accounts receivable, net	1,417	1,381
Inventory, net	1,910	2,020
Prepaid expenses and other current assets	4,783	5,111
Total current assets	112,878	181,116
Property and equipment, net	19,523	22,267
Right-of-use lease asset	15,829
Restricted cash	909	909
Total assets	149,139	204,292
Current liabilities:
Accounts payable	5,338	8,572
Accrued expenses	9,351	8,485
Accrued payroll and related expenses	5,118	7,509
Lease liability, current portion	2,705
Deferred rent, current portion	0	1,370
Total current liabilities	22,512	25,936
Deferred rent, less current portion	0	13,609
Lease liability, less current portion	27,199
Deferred royalty obligation, net	124,366	124,323
Other noncurrent liabilities	10,233	4,503
Total liabilities	184,310	168,371
Shareholders’ (deficit) equity:
Common Stock, $0.0001 par value; 100,000,000 shares authorized, 27,147,387 and 26,259,254 shares issued and outstanding at September 30, 2019 and December 31, 2018, respectively	3	3
Additional paid-in capital	973,018	950,258
Accumulated deficit	(1,012,098)	(920,983)
Total shareholders’ (deficit) equity	(35,171)	35,921
Total liabilities and shareholders’ (deficit) equity	149,139	204,292
Series C-1 Convertible Preferred Stock [Member]
Shareholders’ (deficit) equity:
Convertible preferred stock, value	3,906	3,906
Series F Convertible Preferred Stock [Member]
Shareholders’ (deficit) equity:
Convertible preferred stock, value	$ 0	$ 2,737