Unaudited Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Operating activities
Net loss	$ (62,101)	$ (103,306)
Adjustments to reconcile net loss to net cash used for operating activities:
Share-based compensation expense	13,103	19,246
Depreciation expense	2,263	2,088
Loss on disposal of equipment	15	150
Accretion of right-of-use lease asset	(602)
Non-cash interest expense	4,678	1,655
Changes in operating assets and liabilities:
Accounts receivable, net	(512)	(372)
Inventory, net	52	(939)
Prepaid expenses and other current assets	22	(2,135)
Accounts payable	(3,664)	(5,415)
Accrued expenses	974	4,608
Accrued payroll and related expenses	(3,429)	(377)
Deferred rent	0	1,376
Net cash used for operating activities	(49,201)	(83,421)
Investing activities
Purchase of property and equipment	(441)	(1,881)
Net cash used for investing activities	(441)	(1,881)
Financing activities
Proceeds from the issuance of common stock under ESPP	484	0
Proceeds From Royalties Financing	0	124,289
Net proceeds from the issuance of common stock	0	109,809
Net proceeds from the exercise of stock options for common stock	0	1,716
Net cash provided by financing activities	484	235,814
Net (decrease) increase in cash and restricted cash	(49,158)	150,512
Cash and restricted cash at beginning of period	173,513	91,824
Cash and restricted cash at end of period	124,355	242,336
Supplemental disclosure of non-cash investing and financing activities:
Noncash Or Part Noncash Transaction, Conversion Of Preferred Stock, Common Stock	2,737	0
Initial recognition of right-of-use lease asset	16,798
Reconciliation of cash and restricted cash to the condensed consolidated balance sheets
Total cash and restricted cash	$ 173,513	$ 91,824