Unaudited Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenue
Net product sales	$ 5,703	$ 1,593	$ 10,098	$ 2,402
Total revenue	5,703	1,593	10,098	2,402
Operating expenses
Cost of product sales	551	129	1,051	187
Research and development	22,043	30,867	43,287	59,296
Selling, general and administrative	11,323	22,164	23,643	45,180
Total operating expenses	33,917	53,160	67,981	104,663
Loss from operations	(28,214)	(51,567)	(57,883)	(102,261)
Interest expense	(2,806)	(1,654)	(5,535)	(1,654)
Interest income	604	443	1,317	609
Total other expense, net	(2,202)	(1,211)	(4,218)	(1,045)
Net loss	$ (30,416)	$ (52,778)	$ (62,101)	$ (103,306)
Net loss per share, basic and diluted (usd per share)	$ (1.12)	$ (2.02)	$ (2.29)	$ (4.22)
Weighted-average common shares outstanding - basic and diluted (in shares)	27,108	26,182	27,071	24,462