Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018
Current assets:
Cash	$ 123,446	$ 172,604
Accounts receivable, net	1,893	1,381
Inventory, net	1,968	2,020
Prepaid expenses and other current assets	5,089	5,111
Total current assets	132,396	181,116
Property and equipment, net	20,430	22,267
Right-of-use lease asset	16,159
Restricted cash	909	909
Total assets	169,894	204,292
Current liabilities:
Accounts payable	4,908	8,572
Accrued expenses	10,347	8,485
Accrued payroll and related expenses	4,080	7,509
Lease liability, current portion	2,646
Deferred rent, current portion	0	1,370
Total current liabilities	21,981	25,936
Deferred rent, less current portion	0	13,609
Lease liability, less current portion	27,890
Deferred royalty obligation, net	124,351	124,323
Other noncurrent liabilities	8,265	4,503
Total liabilities	182,487	168,371
Shareholders’ (deficit) equity:
Common Stock, $0.0001 par value; 100,000,000 shares authorized, 27,125,215 and 26,259,254 shares issued and outstanding at June 30, 2019 and December 31, 2018, respectively	3	3
Additional paid-in capital	966,422	950,258
Accumulated deficit	(982,924)	(920,983)
Total shareholders’ (deficit) equity	(12,593)	35,921
Total liabilities and shareholders’ (deficit) equity	169,894	204,292
Series C-1 Convertible Preferred Stock [Member]
Shareholders’ (deficit) equity:
Convertible preferred stock, value	3,906	3,906
Series F Convertible Preferred Stock [Member]
Shareholders’ (deficit) equity:
Convertible preferred stock, value	$ 0	$ 2,737