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Deferred Royalty Obligation (Details) - USD ($)
3 Months Ended
May 10, 2018
Mar. 31, 2019
Dec. 31, 2018
Debt Instrument [Line Items]      
Deferred royalty obligation, net   $ 124,336,000 $ 124,323,000
Royalty Obligation Payable   400,000  
HealthCare Royalty Partners      
Debt Instrument [Line Items]      
Proceeds from royalty agreement $ 125,000,000    
Maximum potential royalty payout 180.00%    
Required payment for breach of agreement, payment one $ 125,000,000.0    
Required payment for breach of agreement, payment two 225,000,000.0    
HealthCare Royalty Partners | Loans Payable | Royalty Financing Agreement      
Debt Instrument [Line Items]      
Deferred royalty obligation, net 125,000,000 124,300,000  
Debt issuance costs $ 700,000    
Interest expense   2,700,000  
Unamortized debt discount   700,000  
Accrued interest expense   9,100,000 6,800,000
Royalty payments   400,000  
HealthCare Royalty Partners | Period One      
Debt Instrument [Line Items]      
Maximum potential royalty payout 10.00%    
HealthCare Royalty Partners | Period Two      
Debt Instrument [Line Items]      
Increase in maximum potential payout percent 4.00%    
HealthCare Royalty Partners | Payout Period      
Debt Instrument [Line Items]      
Increase in maximum potential payout percent 4.00%    
Other Noncurrent Liabilities | HealthCare Royalty Partners | Loans Payable | Royalty Financing Agreement      
Debt Instrument [Line Items]      
Accrued interest expense   $ 6,400,000 $ 4,500,000