Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 140,017	$ 172,604
Accounts receivable, net	1,999	1,381
Inventory, net	1,977	2,020
Prepaid expenses and other current assets	5,139	5,111
Total current assets	149,132	181,116
Property and equipment, net	21,306	22,267
Right-of-use lease asset	16,482
Restricted cash	909	909
Total assets	187,829	204,292
Current liabilities:
Accounts payable	3,041	8,572
Accrued expenses	9,572	8,485
Accrued payroll and related expenses	2,036	7,509
Deferred rent, current portion	0	1,370
Lease liability, current portion	2,587
Total current liabilities	17,236	25,936
Deferred rent, less current portion	0	13,609
Lease liability, less current portion	28,572
Deferred royalty obligation, net	124,336	124,323
Other noncurrent liabilities	6,384	4,503
Total liabilities	176,528	168,371
Shareholders’ equity:
Common Stock, $0.0001 par value; 100,000,000 shares authorized, 27,093,026 and 26,259,254 shares issued and outstanding at March 31, 2019 and December 31, 2018, respectively	3	3
Additional paid-in capital	959,900	950,258
Accumulated deficit	(952,508)	(920,983)
Total shareholders’ equity	11,301	35,921
Total liabilities and shareholders’ equity	187,829	204,292
Series C-1 Convertible Preferred Stock [Member]
Shareholders’ equity:
Convertible preferred stock, value	3,906	3,906
Series F Convertible Preferred Stock [Member]
Shareholders’ equity:
Convertible preferred stock, value	$ 0	$ 2,737