Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2018

Commitments and Contingencies Disclosure [Abstract]

Future minimum annual lease payments under lease agreements

Annual future minimum payments under operating leases as of December 31, 2018 are as follows (in thousands):

2019	$	3,951
2020	4,070
2021	4,192
2022	4,318
2023	4,447
Thereafter	18,308
Total future minimum lease payments	$	39,286

Annual future minimum licensing payments

Annual future minimum licensing payments under the Company’s agreements as of December 31, 2018 are as follows (in thousands):

2019	$	120
2020	120
2021	120
2022	120
2023	120
Total future minimum license payments	$	600

Annual future minimum payments for manufacturing and supply agreements

Annual future minimum payments for manufacturing and supply agreements as of December 31, 2018 are as follows (in thousands):

2019	$	2,759
2020	2,759
2021	2,759
Total future minimum manufacturing and supply agreement payments	$	8,277