Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 172,604	$ 90,915
Accounts receivable, net	1,381	0
Inventory, net	2,020	0
Prepaid expenses and other current assets	5,111	3,147
Total current assets	181,116	94,062
Property and equipment, net	22,267	24,568
Restricted cash	909	909
Total assets	204,292	119,539
Current liabilities:
Accounts payable	8,572	11,484
Accrued expenses	12,988	703
Accrued payroll and related expenses	7,509	4,995
Deferred rent, current portion	1,370	1,370
Total current liabilities	30,439	18,552
Deferred rent, less current portion	13,609	12,785
Deferred royalty obligation, net	124,323	0
Total liabilities	168,371	31,337
Commitments and contingencies (Note 11)
Shareholders’ equity:
Common Stock, $0.0001 par value; 100,000,000 shares authorized, 26,259,254 and 22,167,529 shares issued and outstanding at December 31, 2018 and December 31, 2017, respectively	3	2
Additional paid-in capital	950,258	803,071
Accumulated deficit	(920,983)	(721,514)
Total shareholders’ equity	35,921	88,202
Total liabilities and shareholders’ equity	204,292	119,539
Series C-1 Convertible Preferred Stock [Member]
Shareholders’ equity:
Convertible preferred stock, value	3,906	3,906
Series F Convertible Preferred Stock [Member]
Shareholders’ equity:
Convertible preferred stock, value	$ 2,737	$ 2,737