Restructuring (Notes)

12 Months Ended

Dec. 31, 2018

Restructuring and Related Activities [Abstract]

Restructuring

On October 18, 2018, the Company effected a Company-wide realignment to increase its efficiency and focus on achieving its corporate goals. For the year ended December 31, 2018, total expenses related to the Company-wide realignment were $4.0 million, with $1.6 million included in research and development expense and $2.4 million included in general and administrative expense. Total expenses were comprised of $7.7 million for severance costs, offset by a $3.7 million reversal of non-cash, stock-based compensation expense related to forfeited, unvested equity awards. The Company expects to make the final payment resulting from the Company-wide realignment in the first quarter of 2019. As of December 31, 2018, the Company has paid $5.4 million of the $7.7 million cash charges, and the remaining $2.3 million of the cash charges were included in accrued payroll and related expenses.