Unaudited Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017
Operating activities
Net loss	$ (154,051)	$ (76,257)
Adjustments to reconcile net loss to net cash used for operating activities:
Share-based compensation expense	29,126	15,176
Depreciation expense	3,245	899
Loss on disposal of equipment	236	0
Interest expense	4,421	0
Changes in operating assets and liabilities:
Accounts receivable, net	(1,537)	0
Inventory	(1,101)	0
Prepaid expenses and other current assets	(2,700)	(267)
Other assets	0	219
Accounts payable	(4,914)	(413)
Accrued expenses	5,906	(234)
Accrued payroll and related expenses	(73)	1,151
Deferred rent	1,110	0
Net cash used for operating activities	(120,332)	(59,726)
Investing activities
Purchase of property and equipment	(2,252)	(4,288)
Net cash used for investing activities	(2,252)	(4,288)
Financing activities
Net proceeds from royalty financing	124,289	0
Net proceeds from the issuance of common stock	109,809	117,480
Proceeds from the exercise of stock options for common stock	1,908	2,359
Net cash provided by financing activities	236,006	119,839
Net increase in cash, cash equivalents and restricted cash	113,422	55,825
Cash, cash equivalents and restricted cash at beginning of period	91,824	65,926
Cash, cash equivalents and restricted cash at end of period	205,246	121,751
Reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets
Total cash, cash equivalents and restricted cash	$ 91,824	$ 65,926