Unaudited Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenue
Net product sales	$ 3,470	$ 0	$ 5,872	$ 0
Total revenue	3,470	0	5,872	0
Operating expenses
Cost of product sales	256	0	443	0
Research and development	30,439	19,093	89,735	57,666
Selling, general and administrative	21,139	7,390	66,319	18,915
Total operating expenses	51,834	26,483	156,497	76,581
Loss from operations	(48,364)	(26,483)	(150,625)	(76,581)
Interest (expense) income, net	(2,381)	195	(3,426)	324
Net loss	$ (50,745)	$ (26,288)	$ (154,051)	$ (76,257)
Net loss per share, basic and diluted (usd per share)	$ (1.93)	$ (1.19)	$ (6.15)	$ (3.65)
Weighted-average common shares outstanding - basic and diluted (in shares)	26,226	22,125	25,055	20,900

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

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