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Deferred Royalty Obligation (Details) - USD ($)
3 Months Ended 9 Months Ended
May 10, 2018
Sep. 30, 2018
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Debt Instrument [Line Items]          
Deferred royalty obligation, net   $ 124,324,000 $ 124,324,000   $ 0
Interest expense     4,421,000 $ 0  
Accrued interest expense   4,386,000 4,386,000   $ 0
HealthCare Royalty Partners          
Debt Instrument [Line Items]          
Proceeds from royalty agreement $ 125,000,000        
Maximum potential royalty payout 180.00%        
Required payment for breach of agreement, payment one $ 125,000,000.0        
Required payment for breach of agreement, payment two 225,000,000.0        
HealthCare Royalty Partners | Loans Payable | Royalty Financing Agreement          
Debt Instrument [Line Items]          
Deferred royalty obligation, net 125,000,000 124,300,000 124,300,000    
Debt issuance costs $ 700,000        
Interest expense   3,000,000 4,600,000    
Unamortized debt discount   700,000 700,000    
Accrued interest expense   4,400,000 4,400,000    
Royalty payments   $ 200,000 $ 200,000    
HealthCare Royalty Partners | Period One          
Debt Instrument [Line Items]          
Maximum potential royalty payout 10.00%        
HealthCare Royalty Partners | Period Two          
Debt Instrument [Line Items]          
Increase in maximum potential payout percent 4.00%        
HealthCare Royalty Partners | Payout Period          
Debt Instrument [Line Items]          
Increase in maximum potential payout percent 4.00%