Unaudited Condensed Consolidated Statements of Cash Flows - USD ($)	6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017
Operating activities
Net loss	$ (103,306,000)	$ (49,969,000)
Adjustments to reconcile net loss to net cash used for operating activities:
Share-based compensation expense	19,246,000	9,694,000
Depreciation expense	2,088,000	581,000
Loss on disposal of equipment	150,000	0
Interest expense	1,655,000	0
Changes in operating assets and liabilities:
Accounts receivable, net	(372,000)	0
Inventory	(939,000)	0
Prepaid expenses and other current assets	(2,135,000)	(270,000)
Other assets	0	219,000
Accounts payable	(5,415,000)	(732,000)
Accrued expenses	4,608,000	(541,000)
Accrued payroll and related expenses	(377,000)	(214,000)
Deferred rent	1,376,000	0
Net cash used for operating activities	(83,421,000)	(41,232,000)
Investing activities
Purchase of property and equipment	(1,881,000)	(2,021,000)
Net cash used for investing activities	(1,881,000)	(2,021,000)
Financing activities
Net proceeds from royalty financing	124,289,000	0
Net proceeds from the issuance of common stock	109,809,000	117,480,000
Proceeds from the exercise of stock options for common stock	1,716,000	2,074,000
Net cash provided by financing activities	235,814,000	119,554,000
Net increase in cash, cash equivalents and restricted cash	150,512,000	76,301,000
Cash, cash equivalents and restricted cash at beginning of period	91,824,000	65,926,000
Cash, cash equivalents and restricted cash at end of period	242,336,000	142,227,000
Reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets
Total cash, cash equivalents and restricted cash	$ 91,824,000	$ 65,926,000