Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 241,427	$ 90,915
Accounts receivable, net	372	0
Inventory	939	0
Prepaid expenses and other current assets	5,282	3,147
Total current assets	248,020	94,062
Property and equipment, net	24,211	24,568
Restricted cash	909	909
Total assets	273,140	119,539
Current liabilities:
Accounts payable	6,069	11,484
Accrued expenses	6,952	703
Accrued payroll and related expenses	4,618	4,995
Deferred rent, current portion	1,370	1,370
Total current liabilities	19,009	18,552
Deferred rent, less current portion	14,161	12,785
Deferred royalty obligation, net	124,303	0
Total liabilities	157,473	31,337
Shareholders’ equity:
Common Stock, $0.0001 par value; 100,000,000 shares authorized, 26,218,522 and 22,167,529 shares issued and outstanding at June 30, 2018 and December 31, 2017, respectively	3	2
Additional paid-in capital	933,841	803,071
Accumulated deficit	(824,820)	(721,514)
Total shareholders’ equity	115,667	88,202
Total liabilities and shareholders’ equity	273,140	119,539
Series C-1 Convertible Preferred Stock [Member]
Shareholders’ equity:
Convertible preferred stock, value	3,906	3,906
Series F Convertible Preferred Stock [Member]
Shareholders’ equity:
Convertible preferred stock, value	$ 2,737	$ 2,737