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Shareholders' Equity (Tables)
 6 Months Ended
Jun. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of Stock Option Activity
The Company’s stock option activity under its option plans for the six months ended June 30, 2018 was comprised of the following:
 
Shares
Underlying
Stock Options
 
Weighted-
average
Exercise Price
per Share
Outstanding at December 31, 2017
6,037,302

 
$
24.19

Granted
886,900

 
$
30.15

Exercised
(97,937
)
 
$
17.54

Forfeited
(140,757
)
 
$
26.35

Outstanding at June 30, 2018
6,685,508

 
$
25.03
Summary of Share-based Compensation Expense
Total share-based compensation expense related to all share-based awards for the three and six months ended June 30, 2018 and 2017 was comprised of the following (in thousands):
 
Three Months Ended 
 June 30,
 
Six Months Ended 
 June 30,
 
2018
 
2017
 
2018
 
2017
Research and development:
 
 
 
 
 
 
 
   Stock options
$
5,695

 
$
2,563

 
$
11,081

 
$
5,016

   Warrants
6

 
16

 
16

 
33

Research and development share-based compensation expense
5,701

 
2,579

 
11,097

 
5,049

Selling, general and administrative:
 
 
 
 
 
 
 
   Stock options
4,143

 
1,993

 
8,149

 
3,948

   Restricted stock
—

 
—

 
—

 
409

   Warrants
—

 
139

 
—

 
288

Selling, general and administrative share-based compensation expense
4,143

 
2,132

 
8,149

 
4,645

Total share-based compensation expense
$
9,844

 
$
4,711

 
$
19,246

 
$
9,694