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Shareholders' Equity (Tables)
 3 Months Ended
Mar. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of Share-based Compensation Expense
Total share-based compensation expense related to all share-based awards for the three months ended March 31, 2018 and 2017 was comprised of the following (in thousands):
 
Three Months Ended 
 March 31,
 
2018
 
2017
Research and development:
 
 
 
   Stock options
$
5,386

 
$
2,453

   Warrants
10

 
17

Research and development share-based compensation expense
5,396

 
2,470

Selling, general and administrative:
 
 
 
   Stock options
4,006

 
1,955

   Restricted stock
—

 
409

   Warrants
—

 
149

Selling, general and administrative share-based compensation expense
4,006

 
2,513

Total share-based compensation expense
$
9,402

 
$
4,983
Summary of Stock Option Activity
The Company’s stock option activity under its option plans for the three months ended March 31, 2018 was comprised of the following:
 
Shares
Underlying
Stock Options
 
Weighted-
average
Exercise Price
per Share
Outstanding at December 31, 2017
6,037,302

 
$
24.19

Granted
701,900

 
$
30.02

Exercised
(33,854
)
 
$
15.62

Forfeited
(84,178
)
 
$
24.77

Outstanding at March 31, 2018
6,621,170

 
$
24.84