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Quarterly Financial Information (unaudited) (Tables)
 12 Months Ended
Dec. 31, 2017
Quarterly Financial Information Disclosure [Abstract]  
Schedule of quarterly financial information
The following is a summary of the quarterly results of operations for the years ended December 31, 2017 and 2016 (in thousands, except per share amounts):
 
First
Quarter
 
Second
Quarter
 
Third
Quarter
 
Fourth
Quarter
2017
 
 
 
 
 
 
 
Total revenue
$
—

 
$
—

 
$
—

 
$
—

Loss from operations
$
(23,268
)
 
$
(26,830
)
 
$
(26,483
)
 
$
(38,846
)
Net loss
$
(23,240
)
 
$
(26,729
)
 
$
(26,288
)
 
$
(38,546
)
Basic and diluted net loss per share
$
(1.26
)
 
$
(1.21
)
 
$
(1.19
)
 
$
(1.74
)
Weighted-average common shares outstanding - basic and diluted
18,410

 
22,123

 
22,125

 
22,151

2016
 
 
 
 
 
 
 
Total revenue
$
234

 
$
253

 
$
44

 
$
85

Loss from operations
$
(16,534
)
 
$
(15,617
)
 
$
(21,297
)
 
$
(24,924
)
Net loss
$
(16,481
)
 
$
(15,566
)
 
$
(21,251
)
 
$
(24,887
)
Basic and diluted net loss per share
$
(0.96
)
 
$
(0.90
)
 
$
(1.23
)
 
$
(1.44
)
Weighted-average common shares outstanding - basic and diluted
17,210

 
17,211

 
17,211

 
17,280