Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2017

Commitments and Contingencies Disclosure [Abstract]

Future minimum annual lease payments under lease agreements

Annual future minimum payments under operating leases as of December 31, 2017 are as follows (in thousands):

2018	$	1,945
2019	3,951
2020	4,070
2021	4,192
2022	4,318
Thereafter	22,755
Total future minimum lease payments	$	41,231

Annual future minimum licensing payments

Annual future minimum licensing payments under the Company’s agreements as of December 31, 2017 are as follows (in thousands):

2018	$	142
2019	147
2020	148
2021	147
2022	158
Thereafter	53
Total future minimum license payments	$	795

Annual future minimum payments for manufacturing and supply agreements

Annual future minimum payments for manufacturing and supply agreements as of December 31, 2017 are as follows (in thousands):

2018	$	1,092
2019	921
2020	921
2021	921
Total future minimum manufacturing and supply agreement payments	$	3,855