Unaudited Condensed Consolidated Statements of Operations - USD ($) shares in Thousands	3 Months Ended
Mar. 31, 2017	Mar. 31, 2016
Revenue
Contract revenue - related party	$ 0	$ 234,000
Total revenue	0	234,000
Expenses
Research and development	17,765,000	12,715,000
General and administrative	5,503,000	4,053,000
Total expenses	23,268,000	16,768,000
Loss from operations	(23,268,000)	(16,534,000)
Other income, net	28,000	53,000
Net loss	$ (23,240,000)	$ (16,481,000)
Basic and diluted net loss per share (usd per share)	$ (1.26)	$ (0.96)
Shares used in computing basic and diluted net loss per share (in shares)	18,410	17,210

Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income. Excludes changes in equity resulting from investments by owners and distributions to owners.

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Total costs of sales and operating expenses for the period.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Amount of revenue, fees and commissions earned from transactions between (a) a parent company and its subsidiaries; (b) subsidiaries of a common parent; (c) an entity and trusts for the benefit of employees, for example, but not limited to, pension and profit-sharing trusts that are managed by or under the trusteeship of the entity's management; (d) an entity and its principal, owners, management, or members of their immediate families; and (e) affiliates.

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Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

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Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

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