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Income Taxes (Provision for Income Taxes) (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Income Tax Disclosure [Abstract]      
Income tax benefit at statutory federal rate $ (26,583) $ (14,250) $ (7,256)
Research and development credits (1,240) 1,128 991
Expired tax attributes (5) 31 (60)
Change in valuation allowance 25,091 12,042 6,322
Other 2,737 1,049 3
Provision for income taxes $ 0 $ 0 $ 0