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Quarterly Financial Information (unaudited) (Tables)
 12 Months Ended
Dec. 31, 2016
Quarterly Financial Information Disclosure [Abstract]  
Schedule of quarterly financial information
The following is a summary of the quarterly results of operations for the years ended December 31, 2016 and 2015 (in thousands, except per share amounts):
 
First
Quarter
 
Second
Quarter
 
Third
Quarter
 
Fourth
Quarter
2016
 
 
 
 
 
 
 
Total revenue
$
234

 
$
253

 
$
44

 
$
85

Loss from operations
$
(16,534
)
 
$
(15,617
)
 
$
(21,297
)
 
$
(24,924
)
Net loss
$
(16,481
)
 
$
(15,566
)
 
$
(21,251
)
 
$
(24,887
)
Basic and diluted net loss per share
$
(0.96
)
 
$
(0.90
)
 
$
(1.23
)
 
$
(1.44
)
Shares used in computing basic and diluted net loss per share
17,210

 
17,211

 
17,211

 
17,280

2015
 
 
 
 
 
 
 
Total revenue
$
—

 
$
—

 
$
647

 
$
410

Loss from operations
$
(8,966
)
 
$
(10,658
)
 
$
(10,487
)
 
$
(11,858
)
Net loss
$
(8,955
)
 
$
(10,650
)
 
$
(10,474
)
 
$
(11,833
)
Basic and diluted net loss per share
$
(0.59
)
 
$
(0.70
)
 
$
(0.70
)
 
$
(0.69
)
Shares used in computing basic and diluted net loss per share
15,242

 
15,251

 
14,899

 
17,200