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Business (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended 48 Months Ended
Sep. 30, 2015
Jul. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2015
Sep. 30, 2014
Dec. 31, 2012
Organization, Consolidation and Presentation of Financial Statements [Abstract]                
Net cash used for operating activities     $ 25,183 $ 12,879 $ 4,734 $ 44,900    
Schedule of Capitalization, Equity [Line Items]                
Cash and cash equivalents $ 126,467   $ 126,467 $ 48,555 $ 8,629 $ 126,467 $ 48,555 $ 3,405
Underwriting Agreement [Member]                
Schedule of Capitalization, Equity [Line Items]                
Proceeds from the underwriting agreement, including additional shares sold, net of cost $ 104,600 $ 53,100