Organization and Summary of Significant Accounting Policies (Details) (USD $)	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012
Summary of share-based compensation expense related to share-based awards
Share-based compensation expense included in operating expenses	$ 12,373,000	$ 8,604,000
Share-based compensation expense from:
Stock options	7,762,000	7,640,000
Restricted stock awards and restricted stock units	4,611,000	964,000
Share-based compensation expense included in operating expenses	12,373,000	8,604,000
Research and development [Member]
Summary of share-based compensation expense related to share-based awards
Share-based compensation expense included in operating expenses	992,000	805,000
General and administrative [Member]
Summary of share-based compensation expense related to share-based awards
Share-based compensation expense included in operating expenses	$ 11,381,000	$ 7,799,000