Accounts Payable and Accrued Expenses (Details) - USD ($)	Sep. 30, 2017	Dec. 31, 2016
Accounts Payable and Accrued Expenses
Accrued research payables	$ 54,627,000	$ 45,826,000
Accrued compensation and benefits	29,993,000	34,526,000
Accrued settlement costs	0	24,450,000
Accrued rent	19,037,000	19,061,000
Trade payables	19,454,000	14,474,000
Deferred revenue	6,779,000	7,643,000
Deferred compensation	2,724,000	3,262,000
Accrued restructuring	216,000	3,157,000
Accrued transaction processing	2,889,000	3,230,000
Other	23,212,000	18,714,000
Total	$ 158,931,000	$ 174,343,000