Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Accounts Payable and Accrued Expenses
Accrued research payables	$ 54,317	$ 45,826
Accrued compensation and benefits	20,878	34,526
Accrued settlement costs		24,450
Accrued rent	19,127	19,061
Trade payables	17,354	14,474
Deferred revenue	7,147	7,643
Deferred compensation	2,921	3,262
Accrued restructuring	234	3,157
Accrued transaction processing	3,270	3,230
Other	21,684	18,714
Total	$ 146,932	$ 174,343