Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Accounts Payable and Accrued Expenses
Accrued research payables	$ 53,553	$ 45,826
Accrued compensation and benefits	12,653	34,526
Accrued settlement costs		24,450
Accrued rent	18,988	19,061
Trade payables	14,869	14,474
Deferred revenue	6,353	7,643
Deferred compensation	3,123	3,262
Accrued restructuring	276	3,157
Accrued transaction processing	3,955	3,230
Other	21,646	18,714
Total	$ 135,416	$ 174,343